NOAEL Studies
Cosmetic Ingredient
Lauryl Pyrrolidone NOAEL Studies
INCI: LAURYL PYRROLIDONE
CAS: 2687-96-9
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
NTP ICE adme parameters 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE adme parameters | Clint | 19.1 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=1824; Record_ID=adme_parameters_798; Data_Type=Measured; DTXSID=DTXSID4042206; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=19.1; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4042206 |
| NTP ICE adme parameters | Fu | 0.0125 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=1823; Record_ID=adme_parameters_798; Data_Type=Measured; DTXSID=DTXSID4042206; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.0125; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4042206 |
NTP ICE endocrine 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | AC50 | 117.892868514905 | uM | - | - | - | ARPathway2016; AR Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=1090; RecordID=ARPathway2016_134; DatasetName=ARPathway2016; DTXSID=DTXSID4042206; Assay=AR Pathway Model, Agonist; Endpoint=AC50; Response=117.892868514905; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4042206 |
| NTP ICE endocrine | ACC | 75.2912585621506 | uM | - | - | - | ARPathway2016; AR Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=1091; RecordID=ARPathway2016_134; DatasetName=ARPathway2016; DTXSID=DTXSID4042206; Assay=AR Pathway Model, Agonist; Endpoint=ACC; Response=75.2912585621506; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4042206 |
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=1093; RecordID=ARPathway2016_134; DatasetName=ARPathway2016; DTXSID=DTXSID4042206; Assay=AR Pathway Model, Agonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4042206 |
| NTP ICE endocrine | Model Score | 0.0135 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=1092; RecordID=ARPathway2016_134; DatasetName=ARPathway2016; DTXSID=DTXSID4042206; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0.0135; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4042206 |
ECHA 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LOAEL | =90 | mg/kg bw/day | Dog | oral | subchronic; 90 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadf9e4b0a7c65d1c6de0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15673/7/6/2?documentUUID=d089489a-7e2c-4cfe-8b48-8b5d78244c79; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=body weight and weight gain|clinical biochemistry|clinical signs|food consumption and compound intake|haematology|histopathology: non-neoplastic|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|food and/or water consumption|hematology|nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15834829_15834830:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7a172b765062000dea36af6b836c7ce1 |
| ECHA | NOAEL | =30 | mg/kg bw/day | Dog | oral | subchronic; 90 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadf9e4b0a7c65d1c6de0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15673/7/6/2?documentUUID=d089489a-7e2c-4cfe-8b48-8b5d78244c79; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15834829_15834830:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cae866efa0d017981abee66b31dadf19 |
| ECHA | NOEL | =57.6 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadf9e4b0a7c65d1c6de5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15673/7/6/2?documentUUID=d089489a-7e2c-4cfe-8b48-8b5d78244c79; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15839327:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_480cadef37a73b8521f5e79efb3a6a3d |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =7.6 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15631810:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0f2689147cf4016013874e039d59f299 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 3P14VW8FNY | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C16H31NO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3P14VW8FNY"} |
| openFDA substances | FDA UNII substance identifier | 3P14VW8FNY | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C16H31NO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3P14VW8FNY"} |
| openFDA substances | FDA UNII substance identifier | 3P14VW8FNY | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C16H31NO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3P14VW8FNY"} |
| openFDA substances | FDA UNII substance identifier | 3P14VW8FNY | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C16H31NO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3P14VW8FNY"} |