NOAEL Studies Cosmetic Ingredient

Lawsone NOAEL Studies

INCI: LAWSONE (2-HYDROXY-1,4-NAPHTHOQUINONE)

CAS: 83-72-7

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 2 mg/kg bw/day rat oral 91 day Subchronic SCCNFP; 13-Week toxicity study by oral route in rats - 2-Hydroxy-1,4-naphthoquinone. CIT, France. Report No: 11312 TCR. 10.4.1995
SCCNFP Opinion 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCNFP Opinion NOAEL =0.5 % rat oral 7 days NOAEL study p.8
SCCNFP Opinion NOAEL =2 mg/kg bw/day rabbit - 13- week irritation p.2
SCCNFP Opinion NOAEL =2 mg/kg bw/day rabbit - 13-week irritation (ref. 5.1), p.8
SCCNFP Opinion NOAEL =2 mg/kg bw/day - oral - NOAEL study p.2
SCCNFP Opinion NOAEL =7 mg/kg bw/day rabbit - 13-week irritation (ref. 5.1), p.9
SCCNFP Opinion NOAEL =20 mg/kg bw/day - - - NOAEL study Ref. : 12, p.12
SCCNFP Opinion NOAEL =20 mg/kg bw/day human - - dermal absorption Ref. : 12 2, p.11
SCCNFP Opinion NOAEL =300 mg/kg rat dermal 13-week dermal absorption p.19
Regulatory source 12 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 0.5 % rat oral 7 days - p.8
Regulatory source - 2 mg/kg bw/day - oral - - p.3
Regulatory source - 7 mg/kg bw/day - - - - p.12
Regulatory source - 20 mg/kg bw/day - - - - p.12
Regulatory source dermal absorption 2 mg/kg bw/day rat oral 13-week dermal absorption p.27
Regulatory source dermal absorption 7 mg/kg bw/day human - - dermal absorption p.11
Regulatory source dermal absorption 20 mg/kg bw/day human - - dermal absorption p.11
Regulatory source dermal absorption 300 mg/kg rat dermal 13-week dermal absorption p.19
Regulatory source irritation 2 mg/kg bw/day rabbit - 13- week irritation p.2
Regulatory source irritation 2 mg/kg bw/day rabbit - 13-week irritation p.9
Regulatory source irritation 2 mg/kg bw/day rat - 13-week irritation p.19
Regulatory source irritation 7 mg/kg bw/day rabbit - 13-week irritation p.9
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier TLH4A6LV1W UNII - - - chemical -