NOAEL Studies
Cosmetic Ingredient
Linalyl Isobutyrate NOAEL Studies
INCI: LINALYL ISOBUTYRATE
CAS: 78-35-3
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS DB 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS DB | NOAEL | 1000 | mg/kg bw/day | rat | oral | 126 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
EFSA 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA | NOAEL | =117 | mg/kg bw/day | Rat | oral: unspecified | 28 days | short-term toxicity | ENDPOINTSTUDY_ID 696081; TOX_ID 6775 - OP_ID 2155 - EFSA FEEDAP - 2012 - Scientific Opinion on the safety and efficacy of aliphatic, alicyclic and aromatic saturated and unsaturated tertiary alcohols and esters with esters containing tertiary alcohols ethers (chemical group 6) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2966 |
| EFSA | NOAEL | =117 | mg/kg bw/day | Rat | oral: unspecified | 28 days | short-term toxicity | ENDPOINTSTUDY_ID 696081; TOX_ID 6775 - OP_ID 2155 - EFSA FEEDAP - 2012 - Scientific Opinion on the safety and efficacy of aliphatic, alicyclic and aromatic saturated and unsaturated tertiary alcohols and esters with esters containing tertiary alcohols ethers (chemical group 6) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2966 |
NTP ICE acute oral 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | >36300 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_10299; row=10960; data_type=In Vivo; mixture=Chemical; chemical_name=Linalyl isobutyrate; preferred_name=Linalyl isobutyrate; dtxsid=DTXSID6047490; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6047490; source_file=acute_oral.xlsx |
NTP ICE skin sensitization 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=10285; Record_ID=skin_sensitization_invivo_2264; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6047490; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1974: report to RIFM|RIFM 1974; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1975; Not available; 10.1016/0015-6264(75)90241-2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6047490 |
| NTP ICE skin sensitization | Induction dose per skin area | 5184 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=10282; Record_ID=skin_sensitization_invivo_2264; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6047490; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=5184; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1974: report to RIFM|RIFM 1974; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1975; Not available; 10.1016/0015-6264(75)90241-2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6047490 |
| NTP ICE skin sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=10290; Record_ID=skin_sensitization_invivo_2264; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6047490; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1974: report to RIFM|RIFM 1974; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1975; Not available; 10.1016/0015-6264(75)90241-2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6047490 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 8867Y4G46L | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C14H24O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8867Y4G46L"} |
| openFDA substances | FDA UNII substance identifier | 8867Y4G46L | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C14H24O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8867Y4G46L"} |
| openFDA substances | FDA UNII substance identifier | 8867Y4G46L | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C14H24O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8867Y4G46L"} |
| openFDA substances | FDA UNII substance identifier | 8867Y4G46L | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C14H24O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8867Y4G46L"} |