NOAEL Studies Cosmetic Ingredient

Malonic Acid NOAEL Studies

INCI: MALONIC ACID

CAS: 141-82-2

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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CIR Safety Assessment 17 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
CIR Safety Assessment NOAEL =1 % rat oral 2-year inhalation toxicity 2; 20; 0, p.16
CIR Safety Assessment NOAEL =2 % rat oral 90 days repeated dose toxicity 1; 2; 4, p.17
CIR Safety Assessment NOAEL =3 % rat oral 180 days oral toxicity 30; 10; 3, p.17
CIR Safety Assessment NOAEL =170 mg/kg bw/d - oral 10 weeks developmental toxicity 28, 170; 10; 92, p.55
CIR Safety Assessment NOAEL =200 mg/kg bw rat - 4 weeks NOAEL study 200; 4, p.41
CIR Safety Assessment NOAEL =250 mg/kg bw rat oral - developmental toxicity 4; 205; 6, p.21
CIR Safety Assessment NOAEL =263 mg/kg bw rat oral - developmental toxicity 6; 15; 38, p.21
CIR Safety Assessment NOAEL =288 mg/kg bw rat oral - developmental toxicity 6; 15; 38, p.21
CIR Safety Assessment NOAEL =300 mg/kg bw rat - - developmental toxicity 100; 300; 5, p.53
CIR Safety Assessment NOAEL >435 mg/kg bw rat oral 4 weeks oral toxicity 5; 0; 20, p.14
CIR Safety Assessment NOAEL =500 mg/kg bw/d rat oral 13 weeks repeated dose toxicity 10; 0, 50, 150; 500, p.45
CIR Safety Assessment NOAEL =610 mg/kg bw rat oral 90-day repeated dose toxicity 2; 90; 10, p.41
CIR Safety Assessment NOAEL =1000 mg/kg bw rat - - developmental toxicity 0; 54; 35, p.21
CIR Safety Assessment NOAEL =2000 mg/kg bw/d rat - 5 days developmental toxicity 0; 3; 16, p.54
CIR Safety Assessment NOAEL =3333 mg/kg bw rat oral 19 weeks oral toxicity 8; 10; 0, 420, 840, p.16
CIR Safety Assessment NOAEL <4000 mg/kg rat - - NOAEL study 9; 1; 92, p.42
CIR Safety Assessment NOAEL >8000 mg/kg rat dermal - NOAEL study 111; 9; 121, p.43
NTP ICE acute inhalation 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute inhalation LC50 >8.9 mg/L - Inhalation Duration=1 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=3900; Record_ID=acute_inhalation_3082; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID7021659; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=8.9; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021659
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =4.2 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15633154:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_70eff6f8211171fec29ad6d3584a51cc
Regulatory source 18 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 200 mg/kg bw rat - 4 weeks - p.41
Regulatory source - <4000 mg/kg rat - - - p.42
Regulatory source - >8000 mg/kg rat dermal - - p.43
Regulatory source developmental toxicity 170 mg/kg bw/d - oral 10 weeks developmental toxicity p.55
Regulatory source developmental toxicity 250 mg/kg bw rat oral - developmental toxicity p.21
Regulatory source developmental toxicity 263 mg/kg bw rat oral - developmental toxicity p.21
Regulatory source developmental toxicity 288 mg/kg bw rat oral - developmental toxicity p.21
Regulatory source developmental toxicity 300 mg/kg bw rat - - developmental toxicity p.53
Regulatory source developmental toxicity 1000 mg/kg bw rat - - developmental toxicity p.21
Regulatory source developmental toxicity 2000 mg/kg bw/d rat - 5 days developmental toxicity p.54
Regulatory source inhalation toxicity 1 % rat oral 2-year inhalation toxicity p.16
Regulatory source oral toxicity 3 % rat oral 180 days oral toxicity p.17
Regulatory source oral toxicity >435 mg/kg bw rat oral 4 weeks oral toxicity p.14
Regulatory source oral toxicity 3333 mg/kg bw rat oral 19 weeks oral toxicity p.16
Regulatory source repeated dose toxicity 1 % rat oral 13-week repeated dose toxicity p.45
Regulatory source repeated dose toxicity 2 % rat oral 90 days repeated dose toxicity p.17
Regulatory source repeated dose toxicity 500 mg/kg bw/d rat oral 13 weeks repeated dose toxicity p.45
Regulatory source repeated dose toxicity 610 mg/kg bw rat oral 90-day repeated dose toxicity p.41
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 9KX7ZMG0MK UNII - - - chemical -