NOAEL Studies Cosmetic Ingredient

Maltitol NOAEL Studies

INCI: MALTITOL

CAS: 585-88-6

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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CIR Safety Assessment 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
CIR Safety Assessment NOAEL =69.09 % rat - - NOAEL study 3; 20; 4, p.8
CIR Safety Assessment NOAEL =2.5 g/kg/day New Zealand White rabbits (pregnant females) gavage day 6 through day 18 of pregnancy reproductive/developmental toxicity 1, p.6
CIR Safety Assessment NOAEL =4.5 g/kg bw/day Crl:CD(SD)BR rats oral (diet) 52 weeks (chronic toxicity) / 106 weeks (carcinogenicity) chronic toxicity/carcinogenicity 1, p.5
CIR Safety Assessment NOAEL =18 g/kg (rats); 43 g/kg (dogs) rats and dogs oral (diet) 90 days subchronic toxicity 1, p.5
EFSA 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA NOAEL =7600 mg/kg bw/day Rat oral: feed 91 days subchronic EFSA ANS - 2009 - OutputID 401 - no adverse effect observed at single/highest dose - Scientific Opinion on the use of Polyglycitol Syrup as a food additive - doi:10.2903/j.efsa.2009.1413
EFSA NOAEL =15400 mg/kg bw/day Rat oral: feed 91 days subchronic EFSA ANS - 2009 - OutputID 401 - no adverse effect observed at single/highest dose - Scientific Opinion on the use of Polyglycitol Syrup as a food additive - doi:10.2903/j.efsa.2009.1413
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier D65DG142WK UNII - - - chemical -