NOAEL Studies
Cosmetic Ingredient
Manganese Chloride NOAEL Studies
INCI: MANGANESE CHLORIDE
CAS: 7773-01-5
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
ECHA 17 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LEL | =0.5 | mg/kg bw/day | Rat | injection | - | repeat dose other | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c86ee4b0a7c65d2188fa; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10184/7/10/1?documentUUID=21b2077c-cd04-4931-a301-24297fa15c2e; YEAR=2002; ORIGINAL_YEAR=2002; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825597_15825598_15825599:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_36f54a560077c9050fb68844dea1f562 |
| ECHA | LEL | =1 | mg/L | Rat | oral | - | repeat dose other | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c86ee4b0a7c65d218900; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10184/7/10/1?documentUUID=21b2077c-cd04-4931-a301-24297fa15c2e; YEAR=2002; ORIGINAL_YEAR=2002; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825629_15825717:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_92f432b3d4c2799ffd78d7cfc82e2e07 |
| ECHA | LEL | =2 | mg/kg bw/day | Rat | injection | - | repeat dose other | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c86ee4b0a7c65d2188fa; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10184/7/10/1?documentUUID=21b2077c-cd04-4931-a301-24297fa15c2e; YEAR=2002; ORIGINAL_YEAR=2002; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825597_15825598_15825599:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a7d54923dffe36e38869a6190b978fd4 |
| ECHA | LEL | =2 | ppm | Mouse | oral | - | repeat dose other | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c86ee4b0a7c65d218922; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10184/7/10/1?documentUUID=21b2077c-cd04-4931-a301-24297fa15c2e; YEAR=2002; ORIGINAL_YEAR=2002; STUDY_GROUP=ECHA IUCLID:15825882:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_25ce9bb6feb9ee6b8aa0bf7e583ca5b9 |
| ECHA | LEL | =8 | mg/kg bw/day | Rat | injection | - | repeat dose other | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c86ee4b0a7c65d2188fa; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10184/7/10/1?documentUUID=21b2077c-cd04-4931-a301-24297fa15c2e; YEAR=2002; ORIGINAL_YEAR=2002; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825597_15825598_15825599:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f010c8a148bc2971c2ee06161675ffe5 |
| ECHA | LEL | =14.84 | mg/kg bw/day | Rat | oral | - | repeat dose other | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c86ee4b0a7c65d21890e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10184/7/10/1?documentUUID=21b2077c-cd04-4931-a301-24297fa15c2e; YEAR=2002; ORIGINAL_YEAR=2002; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825748_15825749_15826034_15826035:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d9ff7e40a365ce58158355a6e1241043 |
| ECHA | LEL | =15 | mg/kg bw/day | Rat | injection | - | repeat dose other | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c86ee4b0a7c65d218910; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10184/7/10/1?documentUUID=21b2077c-cd04-4931-a301-24297fa15c2e; YEAR=2002; ORIGINAL_YEAR=2002; STUDY_GROUP=ECHA IUCLID:15825762:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_392034eb648f8fa3492890771ca0c119 |
| ECHA | LEL | =20 | mg/L | Rat | oral | - | repeat dose other | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c86ee4b0a7c65d218908; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10184/7/10/1?documentUUID=21b2077c-cd04-4931-a301-24297fa15c2e; YEAR=2002; ORIGINAL_YEAR=2002; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825629_15825717:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5d108055670360b2840de2e8bac212d4 |
| ECHA | LEL | =50 | mg/kg bw/day | Rat | injection | - | repeat dose other | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c86ee4b0a7c65d218920; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10184/7/10/1?documentUUID=21b2077c-cd04-4931-a301-24297fa15c2e; YEAR=2002; ORIGINAL_YEAR=2002; STUDY_GROUP=ECHA IUCLID:15825824:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e039255b487709fd26d4e8957d7892f9 |
| ECHA | LEL | =59.36 | mg/kg bw/day | Rat | oral | - | repeat dose other | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c86ee4b0a7c65d21890e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10184/7/10/1?documentUUID=21b2077c-cd04-4931-a301-24297fa15c2e; YEAR=2002; ORIGINAL_YEAR=2002; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825748_15825749_15826034_15826035:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f77997d6c899e67ceb3eb925050f5209 |
| ECHA | LEL | =100 | mg/kg bw/day | Mouse | oral | - | repeat dose other | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c86ee4b0a7c65d218914; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10184/7/10/1?documentUUID=21b2077c-cd04-4931-a301-24297fa15c2e; YEAR=2002; ORIGINAL_YEAR=2002; STUDY_GROUP=ECHA IUCLID:15825792:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_dad57f41b212f5231a933f635839e768 |
| ECHA | LEL | <=150 | mg/kg bw/day | Rat | oral | - | repeat dose other | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c86ee4b0a7c65d21890c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10184/7/10/1?documentUUID=21b2077c-cd04-4931-a301-24297fa15c2e; YEAR=2002; ORIGINAL_YEAR=2002; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825748_15825749_15826034_15826035:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_dc5853d34f684dfda3e5711d4e6ae2b3 |
| ECHA | LOAEC | =12.5 | mg/kg bw/day | Mouse | injection | - | developmental | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d225e4b0a7c65d231bb5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10184/7/9/3?documentUUID=21b2077c-cd04-4931-a301-24297fa15c2e; YEAR=2002; ORIGINAL_YEAR=2002; STUDY_GROUP=ECHA IUCLID:15821797:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_87fdd9ac5098a77a3b3db8294b99e453 |
| ECHA | NOAEC | =3.9 | mg/m3 | Rabbit | inhalation | subchronic; 6 weeks | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10184/7/6/3?documentUUID=21b2077c-cd04-4931-a301-24297fa15c2e; YEAR=2002; ORIGINAL_YEAR=2002; STUDY_GROUP=ECHA IUCLID:15829351:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8e7f1e9dbe02cb566d15d61bf53f0d1c |
| ECHA | NOAEL | =2 | mg/kg bw/day | Mouse | injection | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d225e4b0a7c65d231bae; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10184/7/9/3?documentUUID=21b2077c-cd04-4931-a301-24297fa15c2e; YEAR=2002; ORIGINAL_YEAR=2002; STUDY_GROUP=ECHA IUCLID:15821050:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b82adc2df34a8da1e79a346decaf2b20 |
| ECHA | NOAEL | =16 | mg/kg bw/day | Rat | oral | short-term; 30 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaefbe4b0a7c65d1cbe52; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10184/7/6/2?documentUUID=21b2077c-cd04-4931-a301-24297fa15c2e; YEAR=2002; ORIGINAL_YEAR=2002; STUDY_GROUP=ECHA IUCLID:15836454:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_757a12a7909320329858629e35da4409 |
| ECHA | NOAEL | =15000 | mg/m3 | Rat | inhalation | - | developmental | GUIDELINE=OECD Guideline 414 (Prenatal Developmental Toxicity Study); QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d225e4b0a7c65d231b9a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10184/7/9/3?documentUUID=21b2077c-cd04-4931-a301-24297fa15c2e; YEAR=2002; ORIGINAL_YEAR=2002; STUDY_GROUP=ECHA IUCLID:15820871:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cabaac22863ca53b2b1630a11904a2db |
ToxValDB ECOTOX 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | LOEL | =250 | umol/kg bw | Rat | injection | short-term; 3 days | short-term | LONG_REF=Pharmacology38(3): 159-166 Rosenberg,D.W., and A. Kappas Comparative Ability of Exogenously Administered Metals to Alter Tissue Levels and Urinary Output of Copper and Zinc 1989; TITLE=Comparative Ability of Exogenously Administered Metals to Alter Tissue Levels and Urinary Output of Copper and Zinc; AUTHOR=Rosenberg,D.W., and A. Kappas; DOI=10.1159/000138533; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=101259; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Biochemistry: Copper (Cu) content|Biochemistry: Zinc content; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600922_15602026:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=d3471dbc2c387cf56c54cbbcba5f5ed3 |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =0.2 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15633166:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d51bf137f60616a2c97666079c08fa7e |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 6YB4901Y90 | UNII | - | - | - | chemical | - |