Is Manganese Chloride safe in cosmetics?
Manganese Chloride has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Manganese Chloride
Also known as: MnCl2, Manganese chloride anhydrous, Manganese chloride (MnCl2), Manganese(II) chloride, EINECS 231-869-6 (+5 more)
INCI: MANGANESE CHLORIDE
Manganese Chloride (CAS 7773-01-5) is a cosmetic cosmetic ingredient functioning as Skin conditioning. Reported NOAEL =2 mg/kg bw/day in Mouse (ECHA); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
Cross-Vertical Regulatory Divergence
Manganese Chloride is classified GHS Danger (H301, H302, H318, H373, H411, H372, H341, H360) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code
Function
Skin conditioning
Editorial assessment
MODERATE
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
manganese(2+) dichloride
InChIKey
GLFNIEUTAYBVOC-UHFFFAOYSA-L
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Allowed in cosmetics; also GRAS as a food-grade nutrient source (21 CFR 184.1446)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Manganese Chloride.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Manganese Chloride. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =2 mg/kg bw/day | injection | Mouse | developmental | ECHA |
| NOAEL | =16 mg/kg bw/day | oral | Rat | short-term | ECHA |
Sensitization Profile
Contact sensitization data for Manganese Chloride based on clinical patch test studies and IFRA standards.
Sensitization Rate
low
Allergen Class
metal
EU Allergen Listed
no
Patch Test Positive Rate
0.1%
Cross-reactivity Group
none
Reaction Type
contact-dermatitis
Source: ESSCA 2019/20; NACDG 2021-22
EPA ToxValDB — Toxicity Values
10 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LD50 | =2330 mg/kg | Mouse | oral | - | ECHA |
| LD50 | =804 mg/kg | Rat | oral | - | ECHA |
| LD50 | =1860 mg/kg | Rat | oral | - | ECHA |
| LD50 | =1712 mg/kg | Rat | oral | - | ECHA |
| LD50 | =850 mg/kg | Rat | oral | - | ECHA |
| LD50 | =619 mg/kg | Rat | oral | - | ECHA |
| LD50 | =138 mg/kg | Rat | oral | - | ECHA |
| LD50 | ~944 mg/kg | Rat | oral | - | ECHA |
| LD50 | =1484.4 mg/kg | Rat | oral | - | ECHA |
| LD50 | =2150 mg/kg | Rat | oral | - | ECHA |
Endocrine Disruptor Evidence (Expanded)
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
Cosmetic-Specific Mechanism
Category: heavy metal
Receptor targets: TR (moderate); ERα (limited)
LOEC: 1 µM
EU status: allowed (trace)
modulator (TR via thyroid uptake interference)
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE; GROUP
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Editorial summary
Preliminary editorial summary for Manganese Chloride — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
potential-allergen
endocrine_disruptor
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Manganese Chloride by CAS number or substance name.
Studies
2
Lowest NOAEL
2 mg/kg bw/day
Highest NOAEL
16 mg/kg bw/day
ECHA
Known Synonyms
MnCl2
Manganese chloride anhydrous
Manganese chloride (MnCl2)
Manganese(II) chloride
EINECS 231-869-6
Scacchite
UNII-6YB4901Y90
Manganese bichloride
manganese(II) dichloride
manganous dichloride
Chemical Function
Softener and conditioner
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
manganese chloride
ChEMBL ID
CHEMBL1200548
Adverse Event Associations
28
Frequently Asked Questions
Is Manganese Chloride allowed in the EU?
Manganese Chloride EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Manganese Chloride do in cosmetics?
Manganese Chloride functions as: Skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 7773-01-5.
What is the NOAEL for Manganese Chloride?
The NOAEL (No Observed Adverse Effect Level) for Manganese Chloride is =2 mg/kg bw/day based on a developmental study via injection route in Mouse. A total of 2 study endpoints are available. Source: ECHA.
Is Manganese Chloride used outside cosmetics?
Manganese Chloride also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Manganese Chloride have different safety status in cosmetics vs industrial chemicals?
Manganese Chloride is classified GHS Danger (H301, H302, H318, H373, H411, H372, H341, H360) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Manganese Chloride compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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Insufficient data
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