Mangostin
INCI: MANGOSTIN (OFTEN SOURCED VIA GARCINIA MANGOSTANA EXTRACTS)
Regulatory Status
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Safety Data
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Expert Verdict
Generally safe at cosmetic concentrations; high concentrations may cause cytotoxicity in vitro; dose-dependent activity warrants formulation at validated levels. A prenylated xanthone from mangosteen (Garcinia mangostana); potent STING agonist; inhibits melanogenesis by downregulating MITF and interfering with RAR/RXR heterodimer formation; demonstrated anti-pigmentation, ROS-scavenging, and UV-protective properties; widely used in Asian cosmetics
Frequently Asked Questions
Is Mangostin safe in cosmetics?
Generally safe at cosmetic concentrations; high concentrations may cause cytotoxicity in vitro; dose-dependent activity warrants formulation at validated levels. A prenylated xanthone from mangosteen (Garcinia mangostana); potent STING agonist; inhibits melanogenesis by downregulating MITF and interfering with RAR/RXR heterodimer formation; demonstrated anti-pigmentation, ROS-scavenging, and UV-protective properties; widely used in Asian cosmetics The EU classifies Mangostin as "permitted". Safety rating: MODERATE.
Is Mangostin allowed in the EU?
Mangostin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Mangostin do in cosmetics?
Mangostin functions as: Antioxidant; anti-inflammatory; antimicrobial; skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 6147-11-1 (α-mangostin).
What is the Margin of Safety for Mangostin?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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