Medicago Sativa Leaf Extract

INCI: MEDICAGO SATIVA LEAF EXTRACT

CAS Number
84082-36-0
Function
Skin conditioning
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status restricted
🇺🇸 US Status permitted
US Notes Allowed - FDA does not pre-approve cosmetic ingredients (except color additives); not listed among prohibited or restricted substances under 21 CFR 700; manufacturer bears responsibility for safety substantiation

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Contains phytoestrogenic compounds (coumestrol, liquiritigenin, isoliquiritigenin) that interact with estrogen receptors ERα and ERβ. Potential for estrogenic activity at higher concentrations warrants caution in leave-on products, especially those applied to large body surface areas. Possible allergenic potential in sensitive individuals.. Rich in vitamins A, C, E, K, and minerals (calcium, potassium, iron); contains saponins, flavonoids, and chlorophyll; demonstrates antioxidant activity

⚠️
Concern Level: Moderate

Regulatory Flags

plant-extract potential-allergen ifra_fragrance fda_food_additive

Frequently Asked Questions

Is Medicago Sativa Leaf Extract safe in cosmetics?

Contains phytoestrogenic compounds (coumestrol, liquiritigenin, isoliquiritigenin) that interact with estrogen receptors ERα and ERβ. Potential for estrogenic activity at higher concentrations warrants caution in leave-on products, especially those applied to large body surface areas. Possible allergenic potential in sensitive individuals.. Rich in vitamins A, C, E, K, and minerals (calcium, potassium, iron); contains saponins, flavonoids, and chlorophyll; demonstrates antioxidant activity The EU classifies Medicago Sativa Leaf Extract as "restricted". Safety rating: MODERATE.

Is Medicago Sativa Leaf Extract allowed in the EU?

Medicago Sativa Leaf Extract EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Medicago Sativa Leaf Extract do in cosmetics?

Medicago Sativa Leaf Extract functions as: Skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 84082-36-0.

What is the Margin of Safety for Medicago Sativa Leaf Extract?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

📱

Is Medicago Sativa Leaf Extract in Your Products?

Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free →

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Medicago Sativa Leaf Extract in your formulation.