NOAEL Studies
Cosmetic Ingredient
Menthol Cosmetic NOAEL Studies
INCI: MENTHOL
CAS: 89-78-1
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
INCHEM_WHO_jecfa_jecmono_v042je21 10 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| INCHEM_WHO_jecfa_jecmono_v042je21 | ADI | range:0-0.20.2 | mg/kg bw/day | - | - | - | Health guidance value | document_id=jecfa_jecmono_v042je21; title=947. Substances structurally related to menthol (WHO Food Additives Series 42); path=mirror/documents/jecfa/jecmono/v042je21.htm; row_hash=46878dd5846c05c9; raw_unit=mg/kg bw; context=Menthol was first evaluated at the eleventh meeting of the Committee (Annex 1, reference 14), when it was allocated an unconditional ADI of 0-0.2 mg/kg bw and a conditional ADI of 0.2-2 mg/kg bw. |
| INCHEM_WHO_jecfa_jecmono_v042je21 | ADI | range:0-0.20.2 | mg/kg bw/day | - | - | - | Health guidance value | document_id=jecfa_jecmono_v042je21; title=947. Substances structurally related to menthol (WHO Food Additives Series 42); path=mirror/documents/jecfa/jecmono/v042je21.htm; row_hash=46878dd5846c05c9; raw_unit=mg/kg bw; context=Menthol was first evaluated at the eleventh meeting of the Committee (Annex 1, reference 14), when it was allocated an unconditional ADI of 0-0.2 mg/kg bw and a conditional ADI of 0.2-2 mg/kg bw. |
| INCHEM_WHO_jecfa_jecmono_v042je21 | ADI | range:0-44 | mg/kg bw/day | - | - | - | Health guidance value | document_id=jecfa_jecmono_v042je21; title=947. Substances structurally related to menthol (WHO Food Additives Series 42); path=mirror/documents/jecfa/jecmono/v042je21.htm; row_hash=fbd739e8755f102e; raw_unit=mg/kg bw; context=At the present meeting, the Committee allocated an ADI of 0-4 mg/kg bw to menthol (see monograph, this volume). |
| INCHEM_WHO_jecfa_jecmono_v042je21 | ADI | range:0-44 | mg/kg bw/day | - | - | - | Health guidance value | document_id=jecfa_jecmono_v042je21; title=947. Substances structurally related to menthol (WHO Food Additives Series 42); path=mirror/documents/jecfa/jecmono/v042je21.htm; row_hash=fbd739e8755f102e; raw_unit=mg/kg bw; context=At the present meeting, the Committee allocated an ADI of 0-4 mg/kg bw to menthol (see monograph, this volume). |
| INCHEM_WHO_jecfa_jecmono_v042je21 | NOEL | =0.017 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v042je21; title=947. Substances structurally related to menthol (WHO Food Additives Series 42); path=mirror/documents/jecfa/jecmono/v042je21.htm; row_hash=1bb5f70d4a075e3e; raw_unit=ug/kg bw; unit_normalization=converted from micrograms; context=There is a safety margin of > 1000 between this NOEL and the daily per capita intake of menthone itself (42 or 17 ug/kg bw) and the total daily per capita intake of menthone including its derivatives (46 or 17 ug/kg bw). |
| INCHEM_WHO_jecfa_jecmono_v042je21 | NOEL | =0.017 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v042je21; title=947. Substances structurally related to menthol (WHO Food Additives Series 42); path=mirror/documents/jecfa/jecmono/v042je21.htm; row_hash=1bb5f70d4a075e3e; raw_unit=ug/kg bw; unit_normalization=converted from micrograms; context=There is a safety margin of > 1000 between this NOEL and the daily per capita intake of menthone itself (42 or 17 ug/kg bw) and the total daily per capita intake of menthone including its derivatives (46 or 17 ug/kg bw). |
| INCHEM_WHO_jecfa_jecmono_v042je21 | NOEL | =50 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v042je21; title=947. Substances structurally related to menthol (WHO Food Additives Series 42); path=mirror/documents/jecfa/jecmono/v042je21.htm; row_hash=b7a85a6e07ce7c22; raw_unit=mg/kg bw per day; context=The NOEL was 50 mg/kg bw per day (Reijnders, 1991b), which is more than 10 000 times the daily per capita intake ('eaters only') of 3 ug/kg bw from its use as a flavouring agent in the United States (see Table 2). |
| INCHEM_WHO_jecfa_jecmono_v042je21 | NOEL | =50 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v042je21; title=947. Substances structurally related to menthol (WHO Food Additives Series 42); path=mirror/documents/jecfa/jecmono/v042je21.htm; row_hash=b7a85a6e07ce7c22; raw_unit=mg/kg bw per day; context=The NOEL was 50 mg/kg bw per day (Reijnders, 1991b), which is more than 10 000 times the daily per capita intake ('eaters only') of 3 ug/kg bw from its use as a flavouring agent in the United States (see Table 2). |
| INCHEM_WHO_jecfa_jecmono_v042je21 | NOEL | =400 | mg/kg bw/day | Rat | - | 28-day | Toxicology study | document_id=jecfa_jecmono_v042je21; title=947. Substances structurally related to menthol (WHO Food Additives Series 42); path=mirror/documents/jecfa/jecmono/v042je21.htm; row_hash=25f190365e719aa7; raw_unit=mg/kg bw per day; context=For menthone, a NOEL of 400 mg/kg bw per day was reported in a 28-day study of toxicity in rats (Madsen et al., 1986). |
| INCHEM_WHO_jecfa_jecmono_v042je21 | NOEL | =400 | mg/kg bw/day | Rat | - | 28-day | Toxicology study | document_id=jecfa_jecmono_v042je21; title=947. Substances structurally related to menthol (WHO Food Additives Series 42); path=mirror/documents/jecfa/jecmono/v042je21.htm; row_hash=25f190365e719aa7; raw_unit=mg/kg bw per day; context=For menthone, a NOEL of 400 mg/kg bw per day was reported in a 28-day study of toxicity in rats (Madsen et al., 1986). |
NTP_ICE_cancer 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_cancer | Top dose | 4000 | ppm | Mouse | - | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=1384; Record_ID=cancer_4710; Data_Type=In Vivo; Formulation_Name=dl-menthol; Mixture=Chemical; DTXSID=DTXSID1020805; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=4000; Response_Unit=ppm; Species=Mouse; Strain=B6C3F1; Sex=Male; Reference=TR-098; URL=https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr098/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020805; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020805 |
| NTP_ICE_cancer | Top dose | 7500 | ppm | Rat | - | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=1381; Record_ID=cancer_4708; Data_Type=In Vivo; Formulation_Name=dl-menthol; Mixture=Chemical; DTXSID=DTXSID1020805; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=7500; Response_Unit=ppm; Species=Rat; Strain=F344/N; Sex=Female; Reference=TR-098; URL=https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr098/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020805; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020805 |
NTP_ICE_endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=8636; RecordID=ARPathway2016_1689; DatasetName=ARPathway2016; DTXSID=DTXSID1020805; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020805 |
NTP_ICE_skin_sensitization 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=10942; Record_ID=skin_sensitization_invivo_2390; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020805; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1973: report to RlFM|RIFM 1973; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1976; Not available; 10.1016/S0015-6264(76)80199-X; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020805 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | 5184 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=10940; Record_ID=skin_sensitization_invivo_2390; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020805; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=5184; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1973: report to RlFM|RIFM 1973; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1976; Not available; 10.1016/S0015-6264(76)80199-X; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020805 |
| NTP_ICE_skin_sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=10946; Record_ID=skin_sensitization_invivo_2390; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020805; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1973: report to RlFM|RIFM 1973; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1976; Not available; 10.1016/S0015-6264(76)80199-X; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020805 |
ToxValDB_ECHA_IUCLID 10 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | NOAEL | >667 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9ffe4b0a7c65d1b3cbd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22569/7/8?documentUUID=a844226f-4e84-432f-8be8-04a61f19865f; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816340_15820455:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_15a4d57c3ae8d07e3c8fab6ad326fb98 |
| ToxValDB_ECHA_IUCLID | NOAEL | >740 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9ffe4b0a7c65d1b3cbd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22569/7/8?documentUUID=a844226f-4e84-432f-8be8-04a61f19865f; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=gross pathology|histopathology: neoplastic|histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=cancer|gross pathology|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816340_15820455:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_cc4d8c874006fcaeda61a423d9d9637f |
| ToxValDB_ECHA_IUCLID | NOAEL | >937 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae2ae4b0a7c65d1c7cce; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22569/7/6/2?documentUUID=a844226f-4e84-432f-8be8-04a61f19865f; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15830955_15849429:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8a58fcade141a0dc5b279e156261f111 |
| ToxValDB_ECHA_IUCLID | NOAEL | =1250 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae2ae4b0a7c65d1c7cdc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22569/7/6/2?documentUUID=a844226f-4e84-432f-8be8-04a61f19865f; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15832178_15849430:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d39194e6096ced413adc6d6d3672367b |
| ToxValDB_ECHA_IUCLID | NOAEL | >1440 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae2ae4b0a7c65d1c7cce; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22569/7/6/2?documentUUID=a844226f-4e84-432f-8be8-04a61f19865f; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15830955_15849429:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_91de3e324d732b3140de441c03d3ee84 |
| ToxValDB_ECHA_IUCLID | NOAEL | =1477.5 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae2ae4b0a7c65d1c7cdc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22569/7/6/2?documentUUID=a844226f-4e84-432f-8be8-04a61f19865f; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15832178_15849430:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_356dff24df8944663f0a6cfc04f3b2c8 |
| ToxValDB_ECHA_IUCLID | NOEL | =185 | mg/kg bw/day | Mouse | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac00e4b0a7c65d1bce78; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15383/7/9/3?documentUUID=e4a370de-a3f3-4a8c-b975-d5df3cd6b858; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15824600:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_634de7046b8f2de78eaba4e45e951266 |
| ToxValDB_ECHA_IUCLID | NOEL | =218 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac00e4b0a7c65d1bce86; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15383/7/9/3?documentUUID=e4a370de-a3f3-4a8c-b975-d5df3cd6b858; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15824602:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_66bdfee13380a851b2b09daf7e0774ba |
| ToxValDB_ECHA_IUCLID | NOEL | =405 | mg/kg bw/day | Hamster | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1c1e4b0a7c65d23007d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15383/7/9/3?documentUUID=e4a370de-a3f3-4a8c-b975-d5df3cd6b858; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15823106:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9f202bcf689eec8ad57089973a31e932 |
| ToxValDB_ECHA_IUCLID | NOEL | =425 | mg/kg bw/day | Rabbit | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac00e4b0a7c65d1bce7c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15383/7/9/3?documentUUID=e4a370de-a3f3-4a8c-b975-d5df3cd6b858; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15824601:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_33d775e713de0f89a882aaa245d9ab01 |
ToxValDB_ECOTOX 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECOTOX | NOEL | =0.19 | % | Mouse | oral | chronic; 728 days | chronic | LONG_REF=Tech.Rep.Ser.No.98, DHEW Publ.No.(NIH) 79-1348, Natl.Cancer Inst., Bethesda, MD:131 p. National Cancer Institute Bioassay of dl-Menthol for Possible Carcinogenicity 1979; TITLE=Bioassay of dl-Menthol for Possible Carcinogenicity; AUTHOR=National Cancer Institute; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=105632; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=Mortality: Survival; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601951_15601952_15608481:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=8c97fe52b1ae61d4bfcc7b0f73f94a33 |
| ToxValDB_ECOTOX | NOEL | =0.36 | % | Mouse | oral | chronic; 728 days | chronic | LONG_REF=Tech.Rep.Ser.No.98, DHEW Publ.No.(NIH) 79-1348, Natl.Cancer Inst., Bethesda, MD:131 p. National Cancer Institute Bioassay of dl-Menthol for Possible Carcinogenicity 1979; TITLE=Bioassay of dl-Menthol for Possible Carcinogenicity; AUTHOR=National Cancer Institute; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=105632; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=Injury: Lymphoma|Mortality: Survival; TOXICOLOGICAL_EFFECT_CATEGORY=cancer|mortality/survival; STUDY_GROUP=ECOTOX:15598463:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=40f9164814f903caf6a88f107b321d77 |
| ToxValDB_ECOTOX | NOEL | =0.7 | % | Rat | oral | chronic; 735 days | chronic | LONG_REF=Tech.Rep.Ser.No.98, DHEW Publ.No.(NIH) 79-1348, Natl.Cancer Inst., Bethesda, MD:131 p. National Cancer Institute Bioassay of dl-Menthol for Possible Carcinogenicity 1979; TITLE=Bioassay of dl-Menthol for Possible Carcinogenicity; AUTHOR=National Cancer Institute; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=105632; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=Mortality: Survival; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECOTOX:15598154:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b30fa34d750154079c713e8cded1547e |
| ToxValDB_ECOTOX | NOEL | =1450 | mg/kg bw/day | Rat | oral | short-term; 1.625 days | short-term | LONG_REF=Mutat. Res.320(3): 189-205 Uno,Y., H. Takasawa, M. Miyagawa, Y. Inoue, T. Murata, and K. Yoshikawa An In Vivo-In Vitro Replicative DNA Synthesis (RDS) Test Using Rat Hepatocytes as an Early Prediction Assay for Nongenotoxic Hepatocarcinogens Screening of 22 Known Positive and 25 Noncarcinogens 1994; TITLE=An In Vivo-In Vitro Replicative DNA Synthesis (RDS) Test Using Rat Hepatocytes as an Early Prediction Assay for Nongenotoxic Hepatocarcinogens Screening of 22 Known Positive and 25 Noncarcinogens; AUTHOR=Uno,Y., H. Takasawa, M. Miyagawa, Y. Inoue, T. Murata, and K. Yoshikawa; DOI=10.1016/0165-1218(94)90046-9; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75058; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Cell(s): Viability; STUDY_GROUP=ECOTOX:15606800:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=0ac24b5164dbe3868bf0ff5168ef73ed |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | YS08XHA860 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C10H20O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"YS08XHA860"} |
| openFDA substances | FDA UNII substance identifier | YS08XHA860 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C10H20O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"YS08XHA860"} |
| openFDA substances | FDA UNII substance identifier | YS08XHA860 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C10H20O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"YS08XHA860"} |
| openFDA substances | FDA UNII substance identifier | YS08XHA860 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C10H20O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"YS08XHA860"} |