Menthol Cosmetic
INCI: MENTHOL
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Menthol Cosmetic. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | ca.375 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | ca.667 mg/kg bw/day | oral | mouse | oral | REACH |
| NOEL | 200 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | ca.1000 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | ca.2143 mg/kg bw/day | oral | mouse | oral | REACH |
| NOAEL | ca.375 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | ca.667 mg/kg bw/day | oral | mouse | oral | REACH |
| NOEL | 200 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | ca.1000 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | ca.2143 mg/kg bw/day | oral | mouse | oral | REACH |
Sensitization Profile
Contact sensitization data for Menthol Cosmetic based on clinical patch test studies and IFRA standards.
Source: EU 2023/1545; SCCS/1459/11
Dermal Penetration Profile
Skin absorption and penetration characteristics of Menthol Cosmetic, relevant to systemic exposure and MoS calculations.
Source: J Pharm Sci 1996
Expert Verdict
Menthol is generally considered safe for use as a counterirritant in cosmetic formulations.
Regulatory Flags
Frequently Asked Questions
Is Menthol Cosmetic safe in cosmetics?
Menthol is generally considered safe for use as a counterirritant in cosmetic formulations. The EU classifies Menthol Cosmetic as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is Menthol Cosmetic allowed in the EU?
Menthol Cosmetic EU regulatory status: permitted. Maximum allowed concentration: 3%. This is based on EU Regulation 1223/2009 and its amendments.
What does Menthol Cosmetic do in cosmetics?
Menthol Cosmetic functions as: counterirritant. It is classified as a Cosmetic Ingredient in our database. CAS number: 89-78-1.
What is the Margin of Safety for Menthol Cosmetic?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Menthol Cosmetic?
The NOAEL (No Observed Adverse Effect Level) for Menthol Cosmetic is ca.375 mg/kg bw/day based on a oral study via oral route in rat. A total of 10 study endpoints are available. Source: REACH.
Compliance Tools
Check Menthol Cosmetic compliance across multiple jurisdictions:
Related Ingredients
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