Good Cosmetic Ingredient NOAEL Data

Meroxapol 105

INCI: MEROXAPOL 105

CAS Number
9003-11-6
Function
Surfactant – cleansing; Surfactant – emulsifying
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted — no specific restriction under 21 CFR

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for Meroxapol 105. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 25000 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 30000 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 480 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 3000 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 1000 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 200 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 500 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 1000 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 1000 mg/kg bw/day oral dog Subchronic COSMOS_DB
NOAEL 40 mg/kg bw/day oral dog Subchronic COSMOS_DB

Expert Verdict

Residual 1,4-dioxane, ethylene oxide, and propylene oxide from ethoxylation must be controlled to ≤10 ppm 1,4-dioxane per SCCS. Monomer ratio PPG(7)–PEG(22)–PPG(7). No direct CIR review of meroxapols; safety relies on read-across.

⚠️
Concern Level: Low

Regulatory Flags

epa_safer_alternative fda_food_additive

Frequently Asked Questions

Is Meroxapol 105 safe in cosmetics?

Residual 1,4-dioxane, ethylene oxide, and propylene oxide from ethoxylation must be controlled to ≤10 ppm 1,4-dioxane per SCCS. Monomer ratio PPG(7)–PEG(22)–PPG(7). No direct CIR review of meroxapols; safety relies on read-across. The EU classifies Meroxapol 105 as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.

Is Meroxapol 105 allowed in the EU?

Meroxapol 105 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Meroxapol 105 do in cosmetics?

Meroxapol 105 functions as: Surfactant – cleansing; Surfactant – emulsifying. It is classified as a cosmetic ingredient in our database. CAS number: 9003-11-6.

What is the Margin of Safety for Meroxapol 105?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Meroxapol 105?

The NOAEL (No Observed Adverse Effect Level) for Meroxapol 105 is 25000 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check Meroxapol 105 compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
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