Good Cosmetic Ingredient NOAEL Data

Meroxapol 251

INCI: MEROXAPOL 251

CAS Number
9003-11-6
Function
Surfactant – cleansing; Surfactant – emulsifying
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted — no specific restriction under 21 CFR

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for Meroxapol 251. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 25000 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 30000 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 480 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 3000 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 1000 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 200 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 500 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 1000 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 1000 mg/kg bw/day oral dog Subchronic COSMOS_DB
NOAEL 40 mg/kg bw/day oral dog Subchronic COSMOS_DB

Expert Verdict

Monomer ratio: PPG(18)–PEG(6)–PPG(18) — very hydrophobic, minimal EO. Lowest 1,4-dioxane risk in the 2XX series. May require co-solvent for adequate dissolution. Verify compatibility in aqueous systems.

⚠️
Concern Level: Low

Regulatory Flags

epa_safer_alternative fda_food_additive

Frequently Asked Questions

Is Meroxapol 251 safe in cosmetics?

Monomer ratio: PPG(18)–PEG(6)–PPG(18) — very hydrophobic, minimal EO. Lowest 1,4-dioxane risk in the 2XX series. May require co-solvent for adequate dissolution. Verify compatibility in aqueous systems. The EU classifies Meroxapol 251 as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.

Is Meroxapol 251 allowed in the EU?

Meroxapol 251 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Meroxapol 251 do in cosmetics?

Meroxapol 251 functions as: Surfactant – cleansing; Surfactant – emulsifying. It is classified as a cosmetic ingredient in our database. CAS number: 9003-11-6.

What is the Margin of Safety for Meroxapol 251?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Meroxapol 251?

The NOAEL (No Observed Adverse Effect Level) for Meroxapol 251 is 25000 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check Meroxapol 251 compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
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