Good Cosmetic Ingredient NOAEL Data

Meroxapol 254

INCI: MEROXAPOL 254

CAS Number

9003-11-6

Function

Surfactant – cleansing; Surfactant – emulsifying

Safety Rating

GOOD

Regulatory Status

🇪🇺 EU Status permitted

🇺🇸 US Status permitted

US Notes Permitted — no specific restriction under 21 CFR

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)

adequate

Dermal Absorption

negligible

Sensitization

low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for Meroxapol 254. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint	Value	Route	Species	Study Type	Source
NOAEL	25000 mg/kg bw/day	oral	rat	Short Term Toxicity	COSMOS_DB
NOAEL	30000 mg/kg bw/day	oral	rat	Short Term Toxicity	COSMOS_DB
NOAEL	480 mg/kg bw/day	oral	rat	Short Term Toxicity	COSMOS_DB
NOAEL	3000 mg/kg bw/day	oral	rat	Short Term Toxicity	COSMOS_DB
NOAEL	1000 mg/kg bw/day	oral	rat	Subchronic	COSMOS_DB
NOAEL	200 mg/kg bw/day	oral	rat	Subchronic	COSMOS_DB
NOAEL	500 mg/kg bw/day	oral	rat	Subchronic	COSMOS_DB
NOAEL	1000 mg/kg bw/day	oral	rat	Subchronic	COSMOS_DB
NOAEL	1000 mg/kg bw/day	oral	dog	Subchronic	COSMOS_DB
NOAEL	40 mg/kg bw/day	oral	dog	Subchronic	COSMOS_DB

Expert Verdict

Monomer ratio: PPG(18)–PEG(34)–PPG(18). Moderate EO content in the 2XX series. Standard 1,4-dioxane controls (≤10 ppm).

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Concern Level: Low

Regulatory Flags

epa_safer_alternative fda_food_additive

Frequently Asked Questions

Is Meroxapol 254 safe in cosmetics?

Monomer ratio: PPG(18)–PEG(34)–PPG(18). Moderate EO content in the 2XX series. Standard 1,4-dioxane controls (≤10 ppm). The EU classifies Meroxapol 254 as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.

Is Meroxapol 254 allowed in the EU?

Meroxapol 254 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Meroxapol 254 do in cosmetics?

Meroxapol 254 functions as: Surfactant – cleansing; Surfactant – emulsifying. It is classified as a cosmetic ingredient in our database. CAS number: 9003-11-6.

What is the Margin of Safety for Meroxapol 254?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Meroxapol 254?

The NOAEL (No Observed Adverse Effect Level) for Meroxapol 254 is 25000 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check Meroxapol 254 compliance across multiple jurisdictions:

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Ingredient Decoder

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82 Allergen Checker

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Substance Compliance

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MoS Calculator

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Heavy Metal Limits

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