NOAEL Studies Cosmetic Ingredient

Methacrylamide NOAEL Studies

INCI: METHACRYLAMIDE

CAS: 79-39-0

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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ECHA 47 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA LOEL 6.8 mg/kg bw/day mouse oral: drinking water - two-generation reproductive toxicity dossier=8337389c-6568-4083-aeeb-e209727629fb.i6z; document=b64a16fc-b980-4415-b4d6-ccdc7c5da29c_8337389c-6568-4083-aeeb-e209727629fb.i6d; document_key=b64a16fc-b980-4415-b4d6-ccdc7c5da29c/8337389c-6568-4083-aeeb-e209727629fb; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1992; ReportDate=1992-07-22; basis=neuropathology; key_result=false; entry_uuid=341df25c-2ba4-4485-a658-8bb874f95fcc
ECHA NOAEL 49 mg/kg bw/day mouse oral: drinking water - two-generation reproductive toxicity dossier=8337389c-6568-4083-aeeb-e209727629fb.i6z; document=b64a16fc-b980-4415-b4d6-ccdc7c5da29c_8337389c-6568-4083-aeeb-e209727629fb.i6d; document_key=b64a16fc-b980-4415-b4d6-ccdc7c5da29c/8337389c-6568-4083-aeeb-e209727629fb; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1992; ReportDate=1992-07-22; basis=other:; key_result=true; entry_uuid=9d8024e4-cddf-49ab-a93b-550d47d0c3f8
ECHA NOAEL 69 mg/kg bw/day mouse oral: drinking water - two-generation reproductive toxicity dossier=8337389c-6568-4083-aeeb-e209727629fb.i6z; document=b64a16fc-b980-4415-b4d6-ccdc7c5da29c_8337389c-6568-4083-aeeb-e209727629fb.i6d; document_key=b64a16fc-b980-4415-b4d6-ccdc7c5da29c/8337389c-6568-4083-aeeb-e209727629fb; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1992; ReportDate=1992-07-22; basis=other:; key_result=true; entry_uuid=4e0632dc-dee0-4faa-8275-eee86ae6f8fd
ECHA NOAEL 71.3 mg/kg bw/day mouse oral: drinking water - two-generation reproductive toxicity dossier=8337389c-6568-4083-aeeb-e209727629fb.i6z; document=b64a16fc-b980-4415-b4d6-ccdc7c5da29c_8337389c-6568-4083-aeeb-e209727629fb.i6d; document_key=b64a16fc-b980-4415-b4d6-ccdc7c5da29c/8337389c-6568-4083-aeeb-e209727629fb; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1992; ReportDate=1992-07-22; basis=other:; key_result=true; entry_uuid=a0239d77-2787-4017-bf35-66fdf1e8380c
ECHA NOAEL <=30 mg/kg bw/day rat oral: gavage - short-term repeated dose toxicity: oral dossier=8337389c-6568-4083-aeeb-e209727629fb.i6z; document=d134f9a5-26a6-4695-93e1-ef51638e5d90_8337389c-6568-4083-aeeb-e209727629fb.i6d; document_key=d134f9a5-26a6-4695-93e1-ef51638e5d90/8337389c-6568-4083-aeeb-e209727629fb; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1999; basis=neuropathology; key_result=false; upper_value=30; entry_uuid=1003dabd-fb46-4a91-af7b-3fbe8af73c42
ECHA NOAEL 100 mg/kg bw/day rabbit oral: gavage - developmental toxicity dossier=8337389c-6568-4083-aeeb-e209727629fb.i6z; document=092458e2-153c-4826-a6e2-1b43aca5d375_8337389c-6568-4083-aeeb-e209727629fb.i6d; document_key=092458e2-153c-4826-a6e2-1b43aca5d375/8337389c-6568-4083-aeeb-e209727629fb; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2022; ReportDate=2022-12-09; basis=mortality; key_result=true; entry_uuid=95caf366-3edb-4b58-a1e8-1a950f0212c7
ECHA NOAEL 150 mg/kg bw/day rabbit oral: gavage - developmental toxicity dossier=8337389c-6568-4083-aeeb-e209727629fb.i6z; document=092458e2-153c-4826-a6e2-1b43aca5d375_8337389c-6568-4083-aeeb-e209727629fb.i6d; document_key=092458e2-153c-4826-a6e2-1b43aca5d375/8337389c-6568-4083-aeeb-e209727629fb; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2022; ReportDate=2022-12-09; basis=other:; key_result=true; entry_uuid=63686120-dc40-4048-9f0f-0fb34d895690
ECHA NOAEL 60 mg/kg bw/day mouse oral: gavage - developmental toxicity dossier=8337389c-6568-4083-aeeb-e209727629fb.i6z; document=b709641c-654b-4e15-b256-851436228548_8337389c-6568-4083-aeeb-e209727629fb.i6d; document_key=b709641c-654b-4e15-b256-851436228548/8337389c-6568-4083-aeeb-e209727629fb; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1991; basis=organ weights and organ / body weight ratios; key_result=false; entry_uuid=ffa6439c-009e-45d8-a209-a0e7d2adc017
ECHA NOAEL 180 mg/kg bw/day mouse oral: gavage - developmental toxicity dossier=8337389c-6568-4083-aeeb-e209727629fb.i6z; document=b709641c-654b-4e15-b256-851436228548_8337389c-6568-4083-aeeb-e209727629fb.i6d; document_key=b709641c-654b-4e15-b256-851436228548/8337389c-6568-4083-aeeb-e209727629fb; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1991; key_result=false; entry_uuid=9f906305-5b59-4bd4-86b0-031bced4921f
ECHA NOAEL 12.5 mg/kg bw/day rat oral: gavage - screening for reproductive / developmental toxicity dossier=8337389c-6568-4083-aeeb-e209727629fb.i6z; document=c44a8a32-f27a-4be8-87e0-3d7ad1f327ac_8337389c-6568-4083-aeeb-e209727629fb.i6d; document_key=c44a8a32-f27a-4be8-87e0-3d7ad1f327ac/8337389c-6568-4083-aeeb-e209727629fb; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2001; basis=body weight and weight gain; key_result=false; entry_uuid=f82fbd87-fa2c-4135-8c36-895ddcde14c1
ECHA NOAEL 50 mg/kg bw/day rat oral: gavage - screening for reproductive / developmental toxicity dossier=8337389c-6568-4083-aeeb-e209727629fb.i6z; document=c44a8a32-f27a-4be8-87e0-3d7ad1f327ac_8337389c-6568-4083-aeeb-e209727629fb.i6d; document_key=c44a8a32-f27a-4be8-87e0-3d7ad1f327ac/8337389c-6568-4083-aeeb-e209727629fb; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2001; basis=other:; key_result=false; entry_uuid=fcd16b9e-e52e-4eee-acb5-9369758b7281
ECHA NOAEL ca.20 mg/kg bw/day rat oral: drinking water - chronic toxicity: oral dossier=8337389c-6568-4083-aeeb-e209727629fb.i6z; document=34c47f56-4c15-4d2d-9d0d-4b22e4e432f3_8337389c-6568-4083-aeeb-e209727629fb.i6d; document_key=34c47f56-4c15-4d2d-9d0d-4b22e4e432f3/8337389c-6568-4083-aeeb-e209727629fb; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1993; basis=neuropathology; key_result=true; entry_uuid=675c1242-ef20-44ca-adca-0f3fda78fe0a
ECHA NOAEL ca.33.6 mg/kg bw/day mouse oral: drinking water - chronic toxicity: oral dossier=8337389c-6568-4083-aeeb-e209727629fb.i6z; document=27274214-6eca-484f-85ff-5b5f1045ee0b_8337389c-6568-4083-aeeb-e209727629fb.i6d; document_key=27274214-6eca-484f-85ff-5b5f1045ee0b/8337389c-6568-4083-aeeb-e209727629fb; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1993; basis=neuropathology; key_result=false; entry_uuid=0ff96757-b50a-445a-83af-1ea98c41933a
ECHA NOAEL 35 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=8337389c-6568-4083-aeeb-e209727629fb.i6z; document=fbd405c3-2f99-47dd-a941-3050b5030992_8337389c-6568-4083-aeeb-e209727629fb.i6d; document_key=fbd405c3-2f99-47dd-a941-3050b5030992/8337389c-6568-4083-aeeb-e209727629fb; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2020; ReportDate=2020-01-30; basis=food consumption and compound intake; key_result=false; entry_uuid=a6a4034e-5ccc-4155-b162-161bcb730616
ECHA NOAEL 75 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=8337389c-6568-4083-aeeb-e209727629fb.i6z; document=fbd405c3-2f99-47dd-a941-3050b5030992_8337389c-6568-4083-aeeb-e209727629fb.i6d; document_key=fbd405c3-2f99-47dd-a941-3050b5030992/8337389c-6568-4083-aeeb-e209727629fb; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2020; ReportDate=2020-01-30; basis=other:; key_result=false; entry_uuid=db6fdd5f-3ea0-4322-ab36-b0ac4d753b6f
ECHA NOAEL 225 mg/kg bw/day mouse intraperitoneal - developmental toxicity dossier=8337389c-6568-4083-aeeb-e209727629fb.i6z; document=a9a52dcf-0cba-44c4-896c-c966d013eef4_8337389c-6568-4083-aeeb-e209727629fb.i6d; document_key=a9a52dcf-0cba-44c4-896c-c966d013eef4/8337389c-6568-4083-aeeb-e209727629fb; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1966; ReportDate=1966-11-22; key_result=false; entry_uuid=e328b38c-1c26-4a83-bb5d-4fd2bf4b277f
ECHA NOAEL 90 mg/kg bw/day mouse intraperitoneal - developmental toxicity dossier=8337389c-6568-4083-aeeb-e209727629fb.i6z; document=a9a52dcf-0cba-44c4-896c-c966d013eef4_8337389c-6568-4083-aeeb-e209727629fb.i6d; document_key=a9a52dcf-0cba-44c4-896c-c966d013eef4/8337389c-6568-4083-aeeb-e209727629fb; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1966; ReportDate=1966-11-22; key_result=false; entry_uuid=cdb49b1b-7974-42fa-8a56-4f6e0f42a680
ECHA NOAEL ca.210 mg/kg bw/day rat oral: drinking water - short-term repeated dose toxicity: oral dossier=8337389c-6568-4083-aeeb-e209727629fb.i6z; document=33e142a1-343e-4e5c-864b-95b1511fb4ba_8337389c-6568-4083-aeeb-e209727629fb.i6d; document_key=33e142a1-343e-4e5c-864b-95b1511fb4ba/8337389c-6568-4083-aeeb-e209727629fb; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1983; basis=neuropathology; key_result=false; entry_uuid=b58d65f7-bd70-40f6-a8e7-0996d6919e81
ECHA NOAEL 125 mg/kg bw/day mouse oral: gavage - short-term repeated dose toxicity: oral dossier=8337389c-6568-4083-aeeb-e209727629fb.i6z; document=be21bf64-4d60-4541-96ed-d4fbceb4b5b9_8337389c-6568-4083-aeeb-e209727629fb.i6d; document_key=be21bf64-4d60-4541-96ed-d4fbceb4b5b9/8337389c-6568-4083-aeeb-e209727629fb; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1979; ReportDate=1979-07-23; basis=body weight and weight gain; key_result=false; entry_uuid=4d5a86b7-ecd8-4b87-9a7c-9d6488650ac4
ECHA LEL ~1500 mg/kg bw/day Rat oral - acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15801/7/3/2?documentUUID=8337389c-6568-4083-aeeb-e209727629fb; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Oral_15802339_15804969:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4a427e9c05189af47584ea5b397f286a
ECHA LEL =200 mg/kg bw/day Rat oral - acute QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15801/7/3/2?documentUUID=8337389c-6568-4083-aeeb-e209727629fb; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Oral_15802339_15804969:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ffacbc9158197b50ae198d0b79b91408
ECHA LEL =1000 mg/kg bw/day Rat oral - acute QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15801/7/3/2?documentUUID=8337389c-6568-4083-aeeb-e209727629fb; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID:15805231:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_20244cd2b2ee7317272ff1acbaa6d6cc
ECHA LEL =1315 mg/kg bw/day Rat oral - acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15801/7/3/2?documentUUID=8337389c-6568-4083-aeeb-e209727629fb; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID:15810011:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ffe314630303bcb1161e643fecf70516
ECHA LEL ~500 mg/kg bw/day Mouse injection - acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61c14e4b096bca877098b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15801/7/3/5?documentUUID=8337389c-6568-4083-aeeb-e209727629fb; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID:15815228:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_781d85f5de7a92efe1ca84bb1fd8ca0b
ECHA LEL ~450 mg/kg bw/day Mouse injection - acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61c66e4b096bca8771cd1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15801/7/3/5?documentUUID=8337389c-6568-4083-aeeb-e209727629fb; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID:15815395:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_542def01b887d98151df09c2ac50ff78
ECHA LEL ~1300 mg/kg bw/day Rat injection - acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61d0de4b096bca8774679; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15801/7/3/5?documentUUID=8337389c-6568-4083-aeeb-e209727629fb; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID:15815775:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3cf54c93083f1e30f31ed44cd9a77c44
ECHA LEL =360 mg/kg bw/day Mouse injection - acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61d0de4b096bca8774701; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15801/7/3/5?documentUUID=8337389c-6568-4083-aeeb-e209727629fb; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID:15815782:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_528cac1a84b1f8c0a2b43695b65595fc
ECHA LOEL =6.8 mg/kg bw/day Mouse oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab68e4b0a7c65d1ba13b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15801/7/9/2?documentUUID=8337389c-6568-4083-aeeb-e209727629fb; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=F1: test mat.|F1: neuropathology; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology|other; STUDY_GROUP=ECHA IUCLID:15858767:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b1b30e9debe50cadeb98c692a3680910
ECHA NOAEL =49 mg/kg bw/day Mouse oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac6ee4b0a7c65d1bf1a0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15801/7/9/3?documentUUID=8337389c-6568-4083-aeeb-e209727629fb; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=fetus: reduction in number of live offspring|fetus: fetal/pup body weight changes; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15820811:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_fdafc93b11f5e7cbeac55b403b074301
ECHA NOAEL =90 mg/kg bw/day Mouse injection - developmental QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d232e4b0a7c65d231f48; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15801/7/9/3?documentUUID=8337389c-6568-4083-aeeb-e209727629fb; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID:15821486:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9f5ce7783040cd294f2702989b0bafdd
ECHA NOAEL =100 mg/kg bw/day Rabbit oral - reproduction developmental GUIDELINE=OECD Guideline 414 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac6ee4b0a7c65d1bf19c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15801/7/9/3?documentUUID=8337389c-6568-4083-aeeb-e209727629fb; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=maternal: mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECHA IUCLID:15821976:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_36bf16408ffacd1de901acd41e1d98ed
ECHA NOAEL =225 mg/kg bw/day Mouse injection - reproduction developmental QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d232e4b0a7c65d231f48; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15801/7/9/3?documentUUID=8337389c-6568-4083-aeeb-e209727629fb; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID:15822802:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f0867c4ffadd40efcd4e256a474ff129
ECHA NOAEL =60 mg/kg bw/day Mouse oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac6ee4b0a7c65d1bf1a6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15801/7/9/3?documentUUID=8337389c-6568-4083-aeeb-e209727629fb; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=maternal: organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECHA IUCLID:15822867:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4301f171b56b34c472f4c24b5b267438
ECHA NOAEL =62.5 mg/m3 Rat inhalation acute; 6 hours acute QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15801/7/6/3?documentUUID=8337389c-6568-4083-aeeb-e209727629fb; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827239_15827240:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_375ea53f2fa535d020041c68f78e6683
ECHA NOAEL =10 mg/m3 Rat inhalation acute; 6 hours acute QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15801/7/6/3?documentUUID=8337389c-6568-4083-aeeb-e209727629fb; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827239_15827240:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_dc775b566edcc0a7af7fa478af9f184e
ECHA NOAEL =12.8 mg/m3 Rat inhalation short-term; 14 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15801/7/6/3?documentUUID=8337389c-6568-4083-aeeb-e209727629fb; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID:15828680:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5f51a740dd4836e4826295f3501224d0
ECHA NOAEL =3.2 mg/m3 Rat inhalation chronic; 16 weeks chronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15801/7/6/3?documentUUID=8337389c-6568-4083-aeeb-e209727629fb; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID:15828795:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_064e4221bf4163fa2540402e85c6572e
ECHA NOAEL ~33.6 mg/kg bw/day Mouse oral chronic; 4 months chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf08e4b0a7c65d1cc351; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15801/7/6/2?documentUUID=8337389c-6568-4083-aeeb-e209727629fb; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=neuropathology; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15832357:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6451e3840a475434e62df13776b0e523
ECHA NOAEL ~210 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf08e4b0a7c65d1cc358; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15801/7/6/2?documentUUID=8337389c-6568-4083-aeeb-e209727629fb; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=neuropathology; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15833147:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f7835540b3bbf39032a5dbda4eddb9e9
ECHA NOAEL ~20 mg/kg bw/day Rat oral chronic; 4 months chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf08e4b0a7c65d1cc35c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15801/7/6/2?documentUUID=8337389c-6568-4083-aeeb-e209727629fb; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=myofibres: neuropathology; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15833201:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_52bcebf637cc2bf07120458ce0e5540d
ECHA NOAEL =30 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf08e4b0a7c65d1cc363; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15801/7/6/2?documentUUID=8337389c-6568-4083-aeeb-e209727629fb; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=neuropathology|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID:15834444:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_32008ab2a48770c79dac5954dc0df4fe
ECHA NOAEL =125 mg/kg bw/day Mouse oral short-term; 14 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cbe6e4b0a7c65d22807c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15801/7/6/2?documentUUID=8337389c-6568-4083-aeeb-e209727629fb; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=body weight and weight gain|neuropathology; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15842236:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_35ae724b35d7d05ad624feda780776f3
ECHA NOAEL =50 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab68e4b0a7c65d1ba12c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15801/7/9/2?documentUUID=8337389c-6568-4083-aeeb-e209727629fb; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=P0: clinical signs|P0: body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs; STUDY_GROUP=ECHA IUCLID:15857375:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_08349383f9ce4e21f5f89259be9c1226
ECHA NOAEL =12.5 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab68e4b0a7c65d1ba14d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15801/7/9/2?documentUUID=8337389c-6568-4083-aeeb-e209727629fb; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=P0: body weight and weight gain|P0: food consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ECHA IUCLID:15857741:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_701a380aa5034c5e7fba9691ecc89b18
ECHA NOAEL =69 mg/kg bw/day Mouse oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab68e4b0a7c65d1ba13b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15801/7/9/2?documentUUID=8337389c-6568-4083-aeeb-e209727629fb; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID:15858400:F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9c4d861f13eb229c381d8d07b5767cba
ECHA NOAEL =71.3 mg/kg bw/day Mouse oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab68e4b0a7c65d1ba13b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15801/7/9/2?documentUUID=8337389c-6568-4083-aeeb-e209727629fb; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID:15858654:M:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2854ec13d89a4b6e75a2b3f62e24f2dd
ECHA NOAEL =150 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab68e4b0a7c65d1ba12c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15801/7/9/2?documentUUID=8337389c-6568-4083-aeeb-e209727629fb; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=F1: developmental neurotoxicity; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15859284:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b5ead1973b731389c90916ba93d8041a
NTP ICE acute oral 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 =1938 mg/kg bw Rat oral acute Rat Acute Oral Toxicity OECD eChemPortal (undated); record_id=acute_oral_10636; row=13988; data_type=In Vivo; mixture=Chemical; chemical_name=Methacrylamide; preferred_name=Methacrylamide; dtxsid=DTXSID8029600; url=https://www.echemportal.org/echemportal/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8029600; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8029600; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =459 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_10630; row=13989; data_type=In Vivo; mixture=Chemical; chemical_name=Methacrylamide; preferred_name=Methacrylamide; dtxsid=DTXSID8029600; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8029600; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8029600; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =1815 mg/kg bw Rat oral acute Rat Acute Oral Toxicity OECD eChemPortal (undated); record_id=acute_oral_10634; row=13990; data_type=In Vivo; mixture=Chemical; chemical_name=Methacrylamide; preferred_name=Methacrylamide; dtxsid=DTXSID8029600; url=https://www.echemportal.org/echemportal/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8029600; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8029600; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =1653 mg/kg bw Rat oral acute Rat Acute Oral Toxicity OECD eChemPortal (undated); record_id=acute_oral_10632; row=13991; data_type=In Vivo; mixture=Chemical; chemical_name=Methacrylamide; preferred_name=Methacrylamide; dtxsid=DTXSID8029600; url=https://www.echemportal.org/echemportal/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8029600; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8029600; source_file=acute_oral.xlsx
NTP ICE endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=11312; RecordID=ARPathway2016_1587; DatasetName=ARPathway2016; DTXSID=DTXSID8029600; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8029600; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8029600
ToxValDB GESTIS DNEL 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL local =2.54 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15633237_15633238:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_25fc5447d443741ef28da8befe44796e
ToxValDB GESTIS DNEL DNEL systemic =7.89 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15633237_15633238:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_947bef66f2815ea2fad4bcb593dd8fca
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier K67NG89J77 UNII - - - chemical -