Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Methacrylamide. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 50 other | dermal | code:3544 | dermal | REACH |
| NOAEL | 12.8 2105 | 1993 | rat | inhalation | REACH |
| NOAEL | 30 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 30 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 62.5 2104 | 1991 | rat | inhalation | REACH |
| NOAEL | ca.700 other | dermal | code:3484 | dermal | REACH |
| NOAEL | ca.20 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | ca.33.6 mg/kg bw/day | oral | mouse | oral | REACH |
| NOAEL | 3.2 2104 | 1991 | rat | inhalation | REACH |
| NOAEL | ca.210 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Classified under GHS as harmful if swallowed, inhaled, or in contact with skin (H302, H312, H332); causes skin and eye irritation (H315, H319). Primary concern in cosmetics is residual monomer content in finished polymers. Structurally related to acrylamide but with a methyl substituent that reduces toxicity; always used in polymerized form in final cosmetic products
Frequently Asked Questions
Is Methacrylamide safe in cosmetics?
Classified under GHS as harmful if swallowed, inhaled, or in contact with skin (H302, H312, H332); causes skin and eye irritation (H315, H319). Primary concern in cosmetics is residual monomer content in finished polymers. Structurally related to acrylamide but with a methyl substituent that reduces toxicity; always used in polymerized form in final cosmetic products The EU classifies Methacrylamide as "permitted". Safety rating: MODERATE. 10 toxicological study endpoint(s) are available in our database.
Is Methacrylamide allowed in the EU?
Methacrylamide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Methacrylamide do in cosmetics?
Methacrylamide functions as: Not officially reported in CosIng; used primarily as a polymerization monomer in copolymer synthesis for cosmetic film-formers and hair fixatives. It is classified as a cosmetic ingredient in our database. CAS number: 79-39-0.
What is the Margin of Safety for Methacrylamide?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Methacrylamide?
The NOAEL (No Observed Adverse Effect Level) for Methacrylamide is 50 other based on a dermal study via dermal route in code:3544. A total of 10 study endpoints are available. Source: REACH.
Compliance Tools
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