Is Methacrylamide safe in cosmetics?
Methacrylamide has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
Methacrylamide
Also known as: 2-Propenamide, 2-methyl-, 2-Methylprop-2-enamide, 2-propenamida, 2-metil, BRN 0605397, Caswell No. 549 (+8 more)
INCI: METHACRYLAMIDE
Methacrylamide (CAS 79-39-0) is a cosmetic cosmetic ingredient functioning as Not officially reported in CosIng; used primarily as a polymerization monomer. NOAEL 20 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 79-39-0 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Methacrylamide is classified GHS CMR hazard (H302, H319, H335, H371, H373, H320, H361) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Not officially reported in CosIng; used primarily as a polymerization monomer in copolymer synthesis for cosmetic film-formers and hair fixatives
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-methylprop-2-enamide
InChIKey
FQPSGWSUVKBHSU-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not prohibited or restricted. Permitted under general cosmetic ingredient provisions; no specific FDA monograph
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Methacrylamide.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Methacrylamide. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =12.5 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =30 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
| NOAEL | =49 mg/kg bw/day | oral | Mouse | developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =50 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =60 mg/kg bw/day | oral | Mouse | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =69 mg/kg bw/day | oral | Mouse | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =71.3 mg/kg bw/day | oral | Mouse | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =90 mg/kg bw/day | injection | Mouse | developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =100 mg/kg bw/day | oral | Rabbit | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =125 mg/kg bw/day | oral | Mouse | short-term | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Methacrylamide across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| KR | prohibited | - | - |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
No specific technical function
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Methacrylamide.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Methacrylamide by CAS number or substance name.
Studies
12
Lowest NOAEL
12.5 mg/kg bw/day
Highest NOAEL
225 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
2-Propenamide, 2-methyl-
2-Methylprop-2-enamide
2-propenamida, 2-metil
BRN 0605397
Caswell No. 549
EINECS 201-202-3
EPA Pesticide Chemical Code 052901
Methacryamide
Methylacrylic amide
Mhoromer BM801
Amid kyseliny methakrylove
UNII-K67NG89J77
alpha-Methyl acrylic amide
Chemical Function
No specific technical function
Regulatory Lists
Indirect additives food contact (10/2018)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL158237
Frequently Asked Questions
Is Methacrylamide allowed in the EU?
Methacrylamide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Methacrylamide do in cosmetics?
Methacrylamide functions as: Not officially reported in CosIng; used primarily as a polymerization monomer in copolymer synthesis for cosmetic film-formers and hair fixatives. It is classified as a cosmetic ingredient in our database. CAS number: 79-39-0.
What is the NOAEL for Methacrylamide?
The NOAEL (No Observed Adverse Effect Level) for Methacrylamide is =12.5 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. A total of 10 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Methacrylamide used outside cosmetics?
Methacrylamide also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Methacrylamide have different safety status in cosmetics vs industrial chemicals?
Methacrylamide is classified GHS CMR hazard (H302, H319, H335, H371, H373, H320, H361) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Methacrylamide compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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