NOAEL Studies Cosmetic Ingredient

Methacrylic Acid NOAEL Studies

INCI: METHACRYLIC ACID

CAS: 79-41-4

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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CIR_vision_codex 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
CIR_vision_codex NOAEL =352 mg/m3 rat inhalation Subchronic repeated dose toxicity {"citation":"13; 70; 4","dose":"Lesions in the nasal turbinates, similar to those observed in Sprague-Dawley rats at the mid-dose level, were present, but were more severe (CIIT 1983).","effect":"e located at the junction of the stratum corneum and stratum granulosum. Focal necrosis and moderate acute dermatitis were associated with these changes occasionally. Lesions in the nasal turbinates, similar to those observed in Sprague-Dawley rats at the mid-dose level, were present, but were more severe (CIIT 1983). Subchronic Toxicity Inhalation In a 13 week inhalation study (daily hours of exposure not stated), rats and mice had local irritation to the upper airways at concentrations of 70.4 to 1056 mg/m3. The NOEL was not established for rats, but for mice it was established at 352 mg/m3 (Greim et al. 1995). The CIIT conducted a study in which male and fe- male Sprague-Dawley rats, F344/N rats, and B6C3F1 mice (20/sex/species/group) were exposed to atmospheres that con- tained 0, 20, 100 or 300 ppm Methacrylic Acid for 90 days, 6 h/day, 5 days/week (CIIT,1983). Test chambers were sampled once every two hours. Ten animals of each sex, species, strain, group were killed on the day following the fourth exposure for microscopic examination. The remaining animals were killed follo...","page":9,"pdf":"PRS338.pdf","row_type":"noael_study","study_id":"PRS338_noael_001"}
CIR_vision_codex NOAEL =352 mg/m3 rat inhalation Subchronic repeated dose toxicity {"citation":"13; 70; 4","dose":"Lesions in the nasal turbinates, similar to those observed in Sprague-Dawley rats at the mid-dose level, were present, but were more severe (CIIT 1983).","effect":"e located at the junction of the stratum corneum and stratum granulosum. Focal necrosis and moderate acute dermatitis were associated with these changes occasionally. Lesions in the nasal turbinates, similar to those observed in Sprague-Dawley rats at the mid-dose level, were present, but were more severe (CIIT 1983). Subchronic Toxicity Inhalation In a 13 week inhalation study (daily hours of exposure not stated), rats and mice had local irritation to the upper airways at concentrations of 70.4 to 1056 mg/m3. The NOEL was not established for rats, but for mice it was established at 352 mg/m3 (Greim et al. 1995). The CIIT conducted a study in which male and fe- male Sprague-Dawley rats, F344/N rats, and B6C3F1 mice (20/sex/species/group) were exposed to atmospheres that con- tained 0, 20, 100 or 300 ppm Methacrylic Acid for 90 days, 6 h/day, 5 days/week (CIIT,1983). Test chambers were sampled once every two hours. Ten animals of each sex, species, strain, group were killed on the day following the fourth exposure for microscopic examination. The remaining animals were killed follo...","page":9,"pdf":"PRS338.pdf","row_type":"noael_study","study_id":"PRS338_noael_001"}
CIR_vision_codex NOAEL =352 mg/m3 rat inhalation Subchronic repeated dose toxicity {"citation":"13; 70; 4","dose":"Lesions in the nasal turbinates, similar to those observed in Sprague-Dawley rats at the mid-dose level, were present, but were more severe (CIIT 1983).","effect":"e located at the junction of the stratum corneum and stratum granulosum. Focal necrosis and moderate acute dermatitis were associated with these changes occasionally. Lesions in the nasal turbinates, similar to those observed in Sprague-Dawley rats at the mid-dose level, were present, but were more severe (CIIT 1983). Subchronic Toxicity Inhalation In a 13 week inhalation study (daily hours of exposure not stated), rats and mice had local irritation to the upper airways at concentrations of 70.4 to 1056 mg/m3. The NOEL was not established for rats, but for mice it was established at 352 mg/m3 (Greim et al. 1995). The CIIT conducted a study in which male and fe- male Sprague-Dawley rats, F344/N rats, and B6C3F1 mice (20/sex/species/group) were exposed to atmospheres that con- tained 0, 20, 100 or 300 ppm Methacrylic Acid for 90 days, 6 h/day, 5 days/week (CIIT,1983). Test chambers were sampled once every two hours. Ten animals of each sex, species, strain, group were killed on the day following the fourth exposure for microscopic examination. The remaining animals were killed follo...","page":9,"pdf":"PRS338.pdf","row_type":"noael_study","study_id":"PRS338_noael_001"}
CIR_vision_codex NOAEL =352 mg/m3 rat inhalation Subchronic repeated dose toxicity {"citation":"13; 70; 4","dose":"Lesions in the nasal turbinates, similar to those observed in Sprague-Dawley rats at the mid-dose level, were present, but were more severe (CIIT 1983).","effect":"e located at the junction of the stratum corneum and stratum granulosum. Focal necrosis and moderate acute dermatitis were associated with these changes occasionally. Lesions in the nasal turbinates, similar to those observed in Sprague-Dawley rats at the mid-dose level, were present, but were more severe (CIIT 1983). Subchronic Toxicity Inhalation In a 13 week inhalation study (daily hours of exposure not stated), rats and mice had local irritation to the upper airways at concentrations of 70.4 to 1056 mg/m3. The NOEL was not established for rats, but for mice it was established at 352 mg/m3 (Greim et al. 1995). The CIIT conducted a study in which male and fe- male Sprague-Dawley rats, F344/N rats, and B6C3F1 mice (20/sex/species/group) were exposed to atmospheres that con- tained 0, 20, 100 or 300 ppm Methacrylic Acid for 90 days, 6 h/day, 5 days/week (CIIT,1983). Test chambers were sampled once every two hours. Ten animals of each sex, species, strain, group were killed on the day following the fourth exposure for microscopic examination. The remaining animals were killed follo...","page":9,"pdf":"PRS338.pdf","row_type":"noael_study","study_id":"PRS338_noael_001"}
NTP_ICE_acute_inhalation 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_inhalation LC50 6.9674 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=2048; Record_ID=acute_inhalation_2263; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID3025542; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=6.9674; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3025542; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3025542
NTP_ICE_acute_inhalation LC50 7.1 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=2049; Record_ID=acute_inhalation_2265; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID3025542; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=7.1; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3025542; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3025542
NTP_ICE_acute_oral 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =1060 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_10638; row=5819; data_type=In Vivo; mixture=Chemical; chemical_name=Methacrylic acid; preferred_name=Methacrylic acid; dtxsid=DTXSID3025542; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3025542; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID3025542; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =1320 mg/kg bw Rat oral acute Rat Acute Oral Toxicity ECHA ChemProp (undated); record_id=acute_oral_10640; row=5820; data_type=In Vivo; mixture=Chemical; chemical_name=Methacrylic acid; preferred_name=Methacrylic acid; dtxsid=DTXSID3025542; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3025542; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID3025542; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =2224 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_10642; row=5818; data_type=In Vivo; mixture=Chemical; chemical_name=Methacrylic acid; preferred_name=Methacrylic acid; dtxsid=DTXSID3025542; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3025542; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID3025542; source_file=acute_oral.xlsx
ToxValDB_DOE_Protective_Action_Criteria 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_DOE_Protective_Action_Criteria LEL =56337.3 mg/m3 Human inhalation - acute LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2006; ORIGINAL_YEAR=2006; STUDY_GROUP=DOE Protective Action Criteria:15516958:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9f65da9b425ac43922c30854caeeed1e
ToxValDB_GESTIS_DNEL 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL local =44 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15633239_15633240:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_386f749ffdbdedfe5b4e9896138008fa
ToxValDB_GESTIS_DNEL DNEL systemic =39.3 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15633239_15633240:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ca32ace551f97f07a186f94b12ea090a
UnifiedCodex:CIR:beta.noael_studies 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
UnifiedCodex:CIR:beta.noael_studies repeated dose toxicity 352 mg/m3 rat inhalation Subchronic repeated dose toxicity SOURCE_SUBDIR=PRS338; REPORT_TITLE=Final Report of the Safety Assessment of Methacrylic Acid1 Methacrylic Acid is an organic acid used at concentrations be- tween 50 and 88 percent to pretreat the nail and maximize the adhe- sion between the nail and artificial nail extender; OPINION_NUMBER=PRS338; COMMITTEE=CIR Expert Panel; REPORT_DATE=09 Budavari 1989; VALUE_TEXT=352; DOSE=Lesions in the nasal turbinates, similar to those observed in Sprague-Dawley rats at the mid-dose level, were present, but were more severe (CIIT 1983).; EFFECT=e located at the junction of the stratum corneum and stratum granulosum. Focal necrosis and moderate acute dermatitis were associated with these changes occasionally. Lesions in the nasal turbinates, similar to those observed in Sprague-Dawley rats at the mid-dose level, were present, but were more severe (CIIT 1983). Subchronic Toxicity Inhalation In a 13 week inhalation study (daily hours of exposure not stated), rats and mice had local irritation to the upper airways at concentrations of 70.4 to 1056 mg/m3. The NOEL was not established for rats, but for mice it was established at 352 mg/m3 (Greim et al. 1995). The CIIT conducted a study in which male and fe- male Sprague-Dawley rats, F344/N rats, and B6C3F1 mice (20/sex/species/group) were exposed to atmospheres that con- tained 0, 20, 100 or 300 ppm Methacrylic Acid for 90 days, 6 h/day, 5 days/week (CIIT,1983). Test chambers were sampled once every two hours. Ten animals of each sex, species, strain, group were killed on the day following the fourth exposure for microscopic examination. The remaining animals were killed follo...; CITATION=13; 70; 4; CITATION_NUMBERS=[13,70,4]; REFERENCE=13; 70; 4; DETAILS_JSON={"cas_number":"79-41-4","citation":"13; 70; 4","dose":"Lesions in the nasal turbinates, similar to those observed in Sprague-Dawley rats at the mid-dose level, were present, but were more severe (CIIT 1983).","duration":"Subchronic","effect":"e located at the junction of the stratum corneum and stratum granulosum. Focal necrosis and moderate acute dermatitis were associated with these changes occasionally. Lesions in the nasal turbinates, similar to those observed in Sprague-Dawley rats at the mid-dose level, were present, but were more severe (CIIT 1983). Subchronic Toxicity Inhalation In a 13 week inhalation study (daily hours of exposure not stated), rats and mice had local irritation to the upper airways at concentrations of 70.4 to 1056 mg/m3. The NOEL was not established for rats, but for mice it was established at 352 mg/m3 (Greim et al. 1995). The CIIT conducted a study in which male and fe- male Sprague-Dawley rats, F344/N rats, and B6C3F1 mice (20/sex/species/group) were exposed to atmospheres that con- tained 0, 20, 100 or 300 ppm Methacrylic Acid for 90 days, 6 h/day, 5 days/week (CIIT,1983). Test chambers were sampled once every two hours. Ten animals of each sex, species, strain, group were killed on the day following the fourth exposure for microscopic examination. The remaining animals were killed follo...","endpoint":"repeated dose toxicity","ingredient":"the Safety Assessment of Methacrylic Acid1 Methacrylic Acid is an organic acid used at concentrations be- tween 50 and 88 percent to pretreat the nail and maximize the adhe- sion between the nail and artificial nail extender","loael_value":"","noael_unit":"mg/m3","noael_value":"352","page":9,"route":"inhalation","species":"rat","study_id":"PRS338_noael_001"}
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 1CS02G8656 UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H6O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"1CS02G8656"}
openFDA substances FDA UNII substance identifier 1CS02G8656 UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H6O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"1CS02G8656"}
openFDA substances FDA UNII substance identifier 1CS02G8656 UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H6O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"1CS02G8656"}
openFDA substances FDA UNII substance identifier 1CS02G8656 UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H6O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"1CS02G8656"}