NOAEL Studies Cosmetic Ingredient

Methacrylic Acid NOAEL Studies

INCI: METHACRYLIC ACID

CAS: 79-41-4

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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CIR Safety Assessment 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
CIR Safety Assessment NOAEL =352 mg/m3 rat inhalation Subchronic repeated dose toxicity 13; 70; 4, p.9
NTP ICE acute inhalation 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute inhalation LC50 6.9674 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=2048; Record_ID=acute_inhalation_2263; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID3025542; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=6.9674; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3025542; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3025542
NTP ICE acute inhalation LC50 7.1 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=2049; Record_ID=acute_inhalation_2265; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID3025542; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=7.1; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3025542; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3025542
NTP ICE acute oral 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 =1060 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_10638; row=5819; data_type=In Vivo; mixture=Chemical; chemical_name=Methacrylic acid; preferred_name=Methacrylic acid; dtxsid=DTXSID3025542; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3025542; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID3025542; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =1320 mg/kg bw Rat oral acute Rat Acute Oral Toxicity ECHA ChemProp (undated); record_id=acute_oral_10640; row=5820; data_type=In Vivo; mixture=Chemical; chemical_name=Methacrylic acid; preferred_name=Methacrylic acid; dtxsid=DTXSID3025542; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3025542; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID3025542; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =2224 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_10642; row=5818; data_type=In Vivo; mixture=Chemical; chemical_name=Methacrylic acid; preferred_name=Methacrylic acid; dtxsid=DTXSID3025542; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3025542; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID3025542; source_file=acute_oral.xlsx
ToxValDB DOE Protective Action Criteria 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB DOE Protective Action Criteria LEL =56337.3 mg/m3 Human inhalation - acute LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2006; ORIGINAL_YEAR=2006; STUDY_GROUP=DOE Protective Action Criteria:15516958:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9f65da9b425ac43922c30854caeeed1e
ToxValDB GESTIS DNEL 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL local =44 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15633239_15633240:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_386f749ffdbdedfe5b4e9896138008fa
ToxValDB GESTIS DNEL DNEL systemic =39.3 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15633239_15633240:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ca32ace551f97f07a186f94b12ea090a
Regulatory source 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source repeated dose toxicity 352 mg/m3 rat inhalation Subchronic repeated dose toxicity p.9
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 1CS02G8656 UNII - - - chemical -