NOAEL Studies Cosmetic Ingredient

Methacryloylethyl Phosphate NOAEL Studies

INCI: METHACRYLOYLETHYL PHOSPHATE

CAS: 52628-03-2

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_oral 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 >2000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_7145; row=7865; data_type=In Vivo; mixture=Chemical; chemical_name=2-Hydroxyethyl methacrylate phosphate; preferred_name=2-Hydroxyethyl methacrylate phosphate; dtxsid=DTXSID4044951; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4044951; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =5621 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_7146; row=7866; data_type=In Vivo; mixture=Chemical; chemical_name=2-Hydroxyethyl methacrylate phosphate; preferred_name=2-Hydroxyethyl methacrylate phosphate; dtxsid=DTXSID4044951; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4044951; source_file=acute_oral.xlsx
ToxValDB_ECHA_IUCLID 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LEL >1000 mg/kg bw/day Rat oral short-term; 14 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb44e4b0a7c65d225892; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11037/7/6/2?documentUUID=d5808694-eceb-403a-89ef-83d8f7b7ac41; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID:15847794:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e1a132793ae390cb68367cd1027f16b0
ToxValDB_ECHA_IUCLID NOAEL =300 mg/kg bw/day Rat oral - reproduction developmental GUIDELINE=EPA OPPTS 870.3700 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac32e4b0a7c65d1bdde1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11037/7/9/3?documentUUID=d5808694-eceb-403a-89ef-83d8f7b7ac41; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=maternal: haematology; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=ECHA IUCLID:15824887:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_682c560f73127b0846a803a40132db4c
ToxValDB_ECHA_IUCLID NOEL =100 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae5ae4b0a7c65d1c8d67; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11037/7/6/2?documentUUID=d5808694-eceb-403a-89ef-83d8f7b7ac41; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=histopathology: nonneoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15849522:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_d63fe133749112ee95d4c053f80b1d47
ToxValDB_ECHA_IUCLID NOEL =1000 mg/kg bw/day Rat oral - developmental GUIDELINE=EPA OPPTS 870.3700 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac32e4b0a7c65d1bdde1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11037/7/9/3?documentUUID=d5808694-eceb-403a-89ef-83d8f7b7ac41; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID:15824886:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e95d0c7d291e74f7ac121a85ec2eb13f
ToxValDB_EPA_TSCA_8e 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EPA_TSCA_8e LEL =1000 mg/kg bw/day Rat oral short-term (developmental); 15 days reproduction developmental STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=8EHQ-16-20512_15-1058_C.pdf; TOXICOLOGICAL_EFFECT=P0: decreased hematocrit, decreased red blood cell counts, decreased hemoglobin levels, decreased mean corpuscular volume, decreased reticulocyte counts, thickening of limiting ridge of the stomach; STUDY_GROUP=EPA TSCA 8e:15956532:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_638c9b706e6e4b32596eb0ee15117a66
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =7.04 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15634364:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_87ee12bb8dae9998b4ad4fbba20ed846
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier P8914Q0ZMM UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"P8914Q0ZMM"}
openFDA substances FDA UNII substance identifier P8914Q0ZMM UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"P8914Q0ZMM"}
openFDA substances FDA UNII substance identifier P8914Q0ZMM UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"P8914Q0ZMM"}
openFDA substances FDA UNII substance identifier P8914Q0ZMM UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"P8914Q0ZMM"}