NOAEL Studies Cosmetic Ingredient

Methenamine NOAEL Studies

INCI: METHENAMINE

CAS: 100-97-0

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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ECHA 43 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA LOAEL 31 mg/kg bw/day other: oral: feed - developmental toxicity dossier=3b5e3054-d461-4c24-8dad-abfbda9eec5a.i6z; document=c0be490e-ac70-4bcf-a1a9-c4feb0e39956_3b5e3054-d461-4c24-8dad-abfbda9eec5a.i6d; document_key=c0be490e-ac70-4bcf-a1a9-c4feb0e39956/3b5e3054-d461-4c24-8dad-abfbda9eec5a; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1973; basis=other:; key_result=true; entry_uuid=6e652616-bbe9-415b-a7ba-71cca6f0aead
ECHA LOAEL 5000 mg/kg bw/day rat oral: drinking water - short-term repeated dose toxicity: oral dossier=3b5e3054-d461-4c24-8dad-abfbda9eec5a.i6z; document=e7af227c-b160-4840-902c-7f24fbeee30c_3b5e3054-d461-4c24-8dad-abfbda9eec5a.i6d; document_key=e7af227c-b160-4840-902c-7f24fbeee30c/3b5e3054-d461-4c24-8dad-abfbda9eec5a; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1968; basis=other:; key_result=false; entry_uuid=e149b01f-d458-4b4c-9be2-f28323398d38
ECHA NOAEL 1000 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=3b5e3054-d461-4c24-8dad-abfbda9eec5a.i6z; document=27a0e040-e19b-42ff-8bdc-2f3700f79df6_3b5e3054-d461-4c24-8dad-abfbda9eec5a.i6d; document_key=27a0e040-e19b-42ff-8bdc-2f3700f79df6/3b5e3054-d461-4c24-8dad-abfbda9eec5a; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1987; basis=other:; key_result=true; entry_uuid=6ac0267c-8695-484e-9e47-c064068a7d7f
ECHA NOAEL >=1500 mg/kg bw/day rat oral: drinking water - sub-chronic toxicity: oral dossier=3b5e3054-d461-4c24-8dad-abfbda9eec5a.i6z; document=7e415307-a362-4798-a2ab-688590148389_3b5e3054-d461-4c24-8dad-abfbda9eec5a.i6d; document_key=7e415307-a362-4798-a2ab-688590148389/3b5e3054-d461-4c24-8dad-abfbda9eec5a; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1968; basis=other:; key_result=true; upper_value=2000; entry_uuid=a02b10a6-045e-4f60-b771-2d617ae11b4c
ECHA NOAEL >=2000 mg/kg bw/day rat oral: drinking water - sub-chronic toxicity: oral dossier=3b5e3054-d461-4c24-8dad-abfbda9eec5a.i6z; document=7e415307-a362-4798-a2ab-688590148389_3b5e3054-d461-4c24-8dad-abfbda9eec5a.i6d; document_key=7e415307-a362-4798-a2ab-688590148389/3b5e3054-d461-4c24-8dad-abfbda9eec5a; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1968; basis=other:; key_result=true; upper_value=2500; entry_uuid=e36ad160-baf8-4076-9ef2-5094ed2111f7
ECHA NOAEL 800 mg/kg bw/day rat intramuscular - sub-chronic toxicity: other route dossier=3b5e3054-d461-4c24-8dad-abfbda9eec5a.i6z; document=6b0e6fcd-6ee2-4075-8f7e-4cafebdfaf09_3b5e3054-d461-4c24-8dad-abfbda9eec5a.i6d; document_key=6b0e6fcd-6ee2-4075-8f7e-4cafebdfaf09/3b5e3054-d461-4c24-8dad-abfbda9eec5a; document_subtype=RepeatedDoseToxicityOther; literature=Name=Unnamed; ReferenceYear=1964; basis=other:; key_result=false; entry_uuid=a31f5d66-bcce-4c17-98e4-06caf49ad32a
ECHA NOAEL 1100 mg/kg bw/day rat intramuscular - sub-chronic toxicity: other route dossier=3b5e3054-d461-4c24-8dad-abfbda9eec5a.i6z; document=6b0e6fcd-6ee2-4075-8f7e-4cafebdfaf09_3b5e3054-d461-4c24-8dad-abfbda9eec5a.i6d; document_key=6b0e6fcd-6ee2-4075-8f7e-4cafebdfaf09/3b5e3054-d461-4c24-8dad-abfbda9eec5a; document_subtype=RepeatedDoseToxicityOther; literature=Name=Unnamed; ReferenceYear=1964; basis=other:; key_result=false; entry_uuid=a8bd5c2a-9c53-4047-bdca-c8a9a10dbf44
ECHA NOAEL >=1.3 mg/kg bw/day rabbit - - sub-chronic toxicity: dermal dossier=3b5e3054-d461-4c24-8dad-abfbda9eec5a.i6z; document=1ddbb83c-d650-4d81-8daa-b79dd7064a24_3b5e3054-d461-4c24-8dad-abfbda9eec5a.i6d; document_key=1ddbb83c-d650-4d81-8daa-b79dd7064a24/3b5e3054-d461-4c24-8dad-abfbda9eec5a; document_subtype=RepeatedDoseToxicityDermal; literature=Name=Unnamed; ReferenceYear=1992; basis=other:; key_result=false; entry_uuid=420147aa-8136-4353-a6f7-bdb22f2a62bd
ECHA NOAEL 15 mg/kg bw/day other: oral: feed - developmental toxicity dossier=3b5e3054-d461-4c24-8dad-abfbda9eec5a.i6z; document=c0be490e-ac70-4bcf-a1a9-c4feb0e39956_3b5e3054-d461-4c24-8dad-abfbda9eec5a.i6d; document_key=c0be490e-ac70-4bcf-a1a9-c4feb0e39956/3b5e3054-d461-4c24-8dad-abfbda9eec5a; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1973; basis=other:; key_result=true; entry_uuid=97e2c22a-8a96-43e5-9d4a-ad30e5fbfc48
ECHA NOAEL >=50 mg/kg bw/day other: subcutaneous - short-term repeated dose toxicity: other route dossier=3b5e3054-d461-4c24-8dad-abfbda9eec5a.i6z; document=5b388a77-9c87-4159-a033-610dbe787e7b_3b5e3054-d461-4c24-8dad-abfbda9eec5a.i6d; document_key=5b388a77-9c87-4159-a033-610dbe787e7b/3b5e3054-d461-4c24-8dad-abfbda9eec5a; document_subtype=RepeatedDoseToxicityOther; literature=Name=Unnamed; ReferenceYear=1968; basis=other:; key_result=false; entry_uuid=01c1905e-3f4c-4bca-9e43-913038e5ec0a
ECHA NOAEL 100 mg/kg bw/day rat oral: feed - one-generation reproductive toxicity dossier=3b5e3054-d461-4c24-8dad-abfbda9eec5a.i6z; document=94bd4ae3-e456-421b-898d-43c5b7e4e630_3b5e3054-d461-4c24-8dad-abfbda9eec5a.i6d; document_key=94bd4ae3-e456-421b-898d-43c5b7e4e630/3b5e3054-d461-4c24-8dad-abfbda9eec5a; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1971; basis=other:; key_result=false; entry_uuid=57a81ff5-069f-4aa5-928a-b207a3f47137
ECHA NOAEL >=80 mg/kg bw/day rat oral: drinking water - chronic toxicity: oral dossier=3b5e3054-d461-4c24-8dad-abfbda9eec5a.i6z; document=1c73d2fa-c2a8-4369-aac8-141a7238511a_3b5e3054-d461-4c24-8dad-abfbda9eec5a.i6d; document_key=1c73d2fa-c2a8-4369-aac8-141a7238511a/3b5e3054-d461-4c24-8dad-abfbda9eec5a; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1977; basis=other:; key_result=true; entry_uuid=dbc5e586-29d8-4e72-84fb-d3df6f077c0f
ECHA NOAEL 2500 mg/kg bw/day mouse oral: drinking water - carcinogenicity: oral dossier=3b5e3054-d461-4c24-8dad-abfbda9eec5a.i6z; document=8812a86c-5421-4c16-aa54-a9e7a390df40_3b5e3054-d461-4c24-8dad-abfbda9eec5a.i6d; document_key=8812a86c-5421-4c16-aa54-a9e7a390df40/3b5e3054-d461-4c24-8dad-abfbda9eec5a; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1968; basis=other:; key_result=false; entry_uuid=56ce0b29-2734-4338-8dc3-af503896feb7
ECHA NOAEL 12500 mg/kg bw/day mouse oral: drinking water - carcinogenicity: oral dossier=3b5e3054-d461-4c24-8dad-abfbda9eec5a.i6z; document=8812a86c-5421-4c16-aa54-a9e7a390df40_3b5e3054-d461-4c24-8dad-abfbda9eec5a.i6d; document_key=8812a86c-5421-4c16-aa54-a9e7a390df40/3b5e3054-d461-4c24-8dad-abfbda9eec5a; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1968; basis=other:; key_result=false; entry_uuid=ccf19d2f-c26a-4677-8072-57d7d9fcb3b4
ECHA NOAEL >=60.65 mg/kg bw/day cat oral: feed - chronic toxicity: oral dossier=3b5e3054-d461-4c24-8dad-abfbda9eec5a.i6z; document=2731cf5f-01c6-41c4-9233-3ddff71ead72_3b5e3054-d461-4c24-8dad-abfbda9eec5a.i6d; document_key=2731cf5f-01c6-41c4-9233-3ddff71ead72/3b5e3054-d461-4c24-8dad-abfbda9eec5a; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1966; ReportDate=1966-10-03; basis=other:; key_result=false; entry_uuid=af2b8169-9590-4fd0-991e-52081332384e
ECHA NOAEL >=732 mg/kg bw/day rat oral: feed - chronic toxicity: oral dossier=3b5e3054-d461-4c24-8dad-abfbda9eec5a.i6z; document=38a2b4f9-49ea-4c1e-a674-72c09fc08725_3b5e3054-d461-4c24-8dad-abfbda9eec5a.i6d; document_key=38a2b4f9-49ea-4c1e-a674-72c09fc08725/3b5e3054-d461-4c24-8dad-abfbda9eec5a; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1966; ReportDate=1966-10-03; basis=other:; key_result=false; entry_uuid=035b4967-0e1d-486e-ac65-f4e40777c0bd
ECHA NOAEL 1130 mg/kg bw/day rat oral: gavage - carcinogenicity: oral dossier=3b5e3054-d461-4c24-8dad-abfbda9eec5a.i6z; document=aebbae7d-46e1-4130-af1c-1b002e376a51_3b5e3054-d461-4c24-8dad-abfbda9eec5a.i6d; document_key=aebbae7d-46e1-4130-af1c-1b002e376a51/3b5e3054-d461-4c24-8dad-abfbda9eec5a; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1964; basis=other:; key_result=false; entry_uuid=bb53148b-dca2-4f4e-a62f-f52f3a57a3ce
ECHA NOAEL 1570 mg/kg bw/day rat oral: gavage - carcinogenicity: oral dossier=3b5e3054-d461-4c24-8dad-abfbda9eec5a.i6z; document=aebbae7d-46e1-4130-af1c-1b002e376a51_3b5e3054-d461-4c24-8dad-abfbda9eec5a.i6d; document_key=aebbae7d-46e1-4130-af1c-1b002e376a51/3b5e3054-d461-4c24-8dad-abfbda9eec5a; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1964; basis=other:; key_result=false; entry_uuid=2601a22b-e292-4767-8851-47a1486999ec
ECHA NOAEL range3000 mg/kg bw/day rat oral: drinking water - carcinogenicity: oral dossier=3b5e3054-d461-4c24-8dad-abfbda9eec5a.i6z; document=aad8b018-1c43-4dd8-84e6-e268d429a59c_3b5e3054-d461-4c24-8dad-abfbda9eec5a.i6d; document_key=aad8b018-1c43-4dd8-84e6-e268d429a59c/3b5e3054-d461-4c24-8dad-abfbda9eec5a; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1970; basis=other:; key_result=false; upper_value=4000; entry_uuid=78fa76fa-56f1-418f-8cd1-5abe4550e434
ECHA NOAEL range4000 mg/kg bw/day rat oral: drinking water - carcinogenicity: oral dossier=3b5e3054-d461-4c24-8dad-abfbda9eec5a.i6z; document=aad8b018-1c43-4dd8-84e6-e268d429a59c_3b5e3054-d461-4c24-8dad-abfbda9eec5a.i6d; document_key=aad8b018-1c43-4dd8-84e6-e268d429a59c/3b5e3054-d461-4c24-8dad-abfbda9eec5a; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1970; basis=other:; key_result=false; upper_value=5000; entry_uuid=ee9a10ca-a3a9-4bbc-81e0-aee0098b12ea
ECHA NOAEL >=1280 mg/kg bw/day rat oral: gavage - repeated dose toxicity: oral dossier=3b5e3054-d461-4c24-8dad-abfbda9eec5a.i6z; document=4b8a331d-419b-45d4-809a-192e049610dd_3b5e3054-d461-4c24-8dad-abfbda9eec5a.i6d; document_key=4b8a331d-419b-45d4-809a-192e049610dd/3b5e3054-d461-4c24-8dad-abfbda9eec5a; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1964; basis=other:; key_result=false; entry_uuid=d43db756-294d-4f89-a1e2-9174ad1f39ad
ECHA NOAEL >=1780 mg/kg bw/day rat oral: gavage - repeated dose toxicity: oral dossier=3b5e3054-d461-4c24-8dad-abfbda9eec5a.i6z; document=4b8a331d-419b-45d4-809a-192e049610dd_3b5e3054-d461-4c24-8dad-abfbda9eec5a.i6d; document_key=4b8a331d-419b-45d4-809a-192e049610dd/3b5e3054-d461-4c24-8dad-abfbda9eec5a; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1964; basis=other:; key_result=false; entry_uuid=723a96c7-7b81-4220-86b1-a2eaca79bdae
ECHA LEL >=2000 mg/kg bw/day Rat dermal acute; 24 hours acute GUIDELINE=OECD Guideline 402 (Acute Dermal Toxicity)|EU Method B.3 (Acute Toxicity (Dermal)); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c614afe4b096bca8753715; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16215/7/3/4?documentUUID=3b5e3054-d461-4c24-8dad-abfbda9eec5a; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID:15790486:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d52f4624948eaec8286196154e4d4925
ECHA LEL >=20000 mg/kg bw/day Rat oral - acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16215/7/3/2?documentUUID=3b5e3054-d461-4c24-8dad-abfbda9eec5a; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID:15803929:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7b9c3916d49ffb3dbc0348978e6871f7
ECHA LOAEL <=2500 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa4ae4b0a7c65d1b51bc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16215/7/9/2?documentUUID=3b5e3054-d461-4c24-8dad-abfbda9eec5a; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID:15860405:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_87bf0970caa41a2076442189b177c914
ECHA LOAEL >=1500 mg/kg bw/day Rat oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa4ae4b0a7c65d1b51bc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16215/7/9/2?documentUUID=3b5e3054-d461-4c24-8dad-abfbda9eec5a; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID:15860765:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e60a201746a4966707604cf2576aec9f
ECHA NOAEL =2500 mg/kg bw/day Mouse oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9cde4b0a7c65d1b2c4e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16215/7/8?documentUUID=3b5e3054-d461-4c24-8dad-abfbda9eec5a; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15817988_15820149:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_50f853a319e5eb6683182d6ce7d66d57
ECHA NOAEL >=1500 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c7fbe4b0a7c65d215e2b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16215/7/8?documentUUID=3b5e3054-d461-4c24-8dad-abfbda9eec5a; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15819991_15819992_15820015_15820151:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_883b5da1205efac5ed72edea57f8159c
ECHA NOAEL <=2000 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c7fbe4b0a7c65d215e2b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16215/7/8?documentUUID=3b5e3054-d461-4c24-8dad-abfbda9eec5a; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15819991_15819992_15820015_15820151:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_23431b74d942a942ab6c1e131667d146
ECHA NOAEL >=3000 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9cde4b0a7c65d1b2c51; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16215/7/8?documentUUID=3b5e3054-d461-4c24-8dad-abfbda9eec5a; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15819991_15819992_15820015_15820151:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e6e22b91099e07dfc1254302fb7e6488
ECHA NOAEL >=4000 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9cde4b0a7c65d1b2c51; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16215/7/8?documentUUID=3b5e3054-d461-4c24-8dad-abfbda9eec5a; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15819993_15819994_15820016_15820150:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_257d4dbec74b381fd4a678ab3cb4e6a3
ECHA NOAEL =100 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9cde4b0a7c65d1b2c48; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16215/7/8?documentUUID=3b5e3054-d461-4c24-8dad-abfbda9eec5a; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID:15820146:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6792632602d138713f1ddbb051f9aa86
ECHA NOAEL =80 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9cde4b0a7c65d1b2c48; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16215/7/8?documentUUID=3b5e3054-d461-4c24-8dad-abfbda9eec5a; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID:15820147:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_bccf92d00ced1cb6f1506ee75ecb55e6
ECHA NOAEL =12500 mg/kg bw/day Mouse oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9cde4b0a7c65d1b2c4e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16215/7/8?documentUUID=3b5e3054-d461-4c24-8dad-abfbda9eec5a; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15817988_15820149:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9d0810e2fdcec50f1c783f12961b5667
ECHA NOAEL <=5000 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9cde4b0a7c65d1b2c51; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16215/7/8?documentUUID=3b5e3054-d461-4c24-8dad-abfbda9eec5a; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15819993_15819994_15820016_15820150:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_d6cf791a4bd643b0c3c632e06be47324
ECHA NOAEL =1570 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9cde4b0a7c65d1b2c54; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16215/7/8?documentUUID=3b5e3054-d461-4c24-8dad-abfbda9eec5a; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID:15820152:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9097639bdda412ae7fa6c40d7d00e959
ECHA NOAEL =1130 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9cde4b0a7c65d1b2c54; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16215/7/8?documentUUID=3b5e3054-d461-4c24-8dad-abfbda9eec5a; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID:15820153:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f246d61bb154c6bb5535a58126dfc4dc
ECHA NOAEL >=1.3 mg/kg bw/day Rabbit dermal subchronic; 6 weeks subchronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61d82e4b096bca877601e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16215/7/6/4?documentUUID=3b5e3054-d461-4c24-8dad-abfbda9eec5a; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID:15826199:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7ba0d034fd0b22455e5fe797f4a3112a
ECHA NOAEL >=60.65 mg/kg bw/day Cat oral chronic; 742 days chronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c9e8e4b0a7c65d21f35f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16215/7/6/2?documentUUID=3b5e3054-d461-4c24-8dad-abfbda9eec5a; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID:15832359:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_325d6ba9e0477bbac7cbec1bf7eeed79
ECHA NOAEL >=1280 mg/kg bw/day Rat oral acute; 1 days acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c9e9e4b0a7c65d21f369; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16215/7/6/2?documentUUID=3b5e3054-d461-4c24-8dad-abfbda9eec5a; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15834682_15834684:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0aa4c4d8489e951140d3a33cd13abfa1
ECHA NOAEL >=1780 mg/kg bw/day Rat oral acute; 1 days acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c9e9e4b0a7c65d21f369; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16215/7/6/2?documentUUID=3b5e3054-d461-4c24-8dad-abfbda9eec5a; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15834683_15834685:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4d2781dff3a861f0053eae2a30632a90
ECHA NOAEL >=25 mg/kg bw/day Dog oral chronic; 189 weeks chronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaca9e4b0a7c65d1c024d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16215/7/6/2?documentUUID=3b5e3054-d461-4c24-8dad-abfbda9eec5a; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID:15847603:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b54253257609734c00cba812eb28dbcf
ECHA NOAEL >=732 mg/kg bw/day Rat oral chronic; 183 days chronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaca9e4b0a7c65d1c0253; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16215/7/6/2?documentUUID=3b5e3054-d461-4c24-8dad-abfbda9eec5a; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID:15848661:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_bd23e5e9696a2cb4e514b67f93955d11
NTP ICE acute oral 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 >5000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_117; row=9976; data_type=In Vivo; mixture=Chemical; chemical_name=Methenamine; preferred_name=Methenamine; dtxsid=DTXSID6020692; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020692; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6020692; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =9200 mg/kg bw Rat oral acute Rat Acute Oral Toxicity JRC AcutoxBase (undated); record_id=acute_oral_119; row=9977; data_type=In Vivo; mixture=Chemical; chemical_name=Methenamine; preferred_name=Methenamine; dtxsid=DTXSID6020692; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020692; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6020692; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 >20000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_121; row=9978; data_type=In Vivo; mixture=Chemical; chemical_name=Methenamine; preferred_name=Methenamine; dtxsid=DTXSID6020692; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020692; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6020692; source_file=acute_oral.xlsx
NTP ICE adme parameters 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE adme parameters Clint 0 uL/min/10^6 cells Human - - Measured; httk, Human Hepatic Intrinsic Clearance sheet=Data; excel_row=2334; Record_ID=adme_parameters_1032; Data_Type=Measured; DTXSID=DTXSID6020692; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=0.0; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020692; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020692
NTP ICE adme parameters Fu 0.352 fraction Human - - Measured; httk, Human Plasma Fraction Unbound sheet=Data; excel_row=2335; Record_ID=adme_parameters_1032; Data_Type=Measured; DTXSID=DTXSID6020692; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.352; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020692; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020692
NTP ICE endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=11344; RecordID=ARPathway2016_406; DatasetName=ARPathway2016; DTXSID=DTXSID6020692; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020692; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020692
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =5.6 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632509:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7027716a6b571c76a09f7c88be14bd36
WHO/JECFA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
WHO/JECFA ADI <=0.15 mg/kg Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650afe8ee4b0d99f5a880741; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/1720; YEAR=1973; ORIGINAL_YEAR=1973; STUDY_GROUP=WHO JECFA ADI:15715568:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d39f7af2cc1cef0710a1ad1c5d48f63f
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier J50OIX95QV UNII - - - chemical -