Is Methenamine safe in cosmetics?
Methenamine has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted.
Moderate
Cosmetic Ingredient
Methenamine
INCI: METHENAMINE
Methenamine (CAS 100-97-0) is a cosmetic cosmetic ingredient functioning as Preservative, Antimicrobial (formaldehyde releaser). EU Regulation 1223/2009 status: restricted, max 0.16%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 100-97-0 →
Auto-generated CPSR Part A draft with source citations
Function
Preservative, Antimicrobial (formaldehyde releaser)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
1,3,5,7-tetrazatricyclo[3.3.1.13,7]decane
InChIKey
VKYKSIONXSXAKP-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
EU Max Conc.
0.16%
US US Status
permitted
US Notes
Allowed - No specific prohibition; subject to general safety requirements
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Methenamine.
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Expert safety assessment and concern-level summary for Methenamine.
Regulatory Flags
potential-allergen
preservative
eu_cosing_listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
METHENAMINE
ChEMBL ID
CHEMBL1201270
Max Phase
4
Adverse Event Associations
177
Frequently Asked Questions
Is Methenamine allowed in the EU?
Methenamine EU regulatory status: restricted. Maximum allowed concentration: 0.16%. This is based on EU Regulation 1223/2009 and its amendments.
What does Methenamine do in cosmetics?
Methenamine functions as: Preservative, Antimicrobial (formaldehyde releaser). It is classified as a cosmetic ingredient in our database. CAS number: 100-97-0.
Is Methenamine used outside cosmetics?
Methenamine also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Methenamine compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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Is Methenamine in Your Products?
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Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Methenamine in your formulation.