Methoxy PEG-450 Amidoglutaroyl Succinimide

INCI: METHOXY PEG-450 AMIDOGLUTAROYL SUCCINIMIDE

CAS Number
Not confirmed from databases accessed
Function
Hair conditioning (based on structural analogy to #7 and COSMILE Europe listing)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not prohibited

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Same profile as #7 - high MW PEG polymer with reactive succinimide group; must ensure complete reaction with target substrates; low penetration risk due to size. Contains a glutaroyl spacer (5-carbon) instead of succinamate - provides different spacing/flexibility for protein binding compared to ingredient #7; synthetic origin; ~20,000 Da molecular weight

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Concern Level: Moderate

Regulatory Flags

peg-ingredient

Frequently Asked Questions

Is Methoxy PEG-450 Amidoglutaroyl Succinimide safe in cosmetics?

Same profile as #7 - high MW PEG polymer with reactive succinimide group; must ensure complete reaction with target substrates; low penetration risk due to size. Contains a glutaroyl spacer (5-carbon) instead of succinamate - provides different spacing/flexibility for protein binding compared to ingredient #7; synthetic origin; ~20,000 Da molecular weight The EU classifies Methoxy PEG-450 Amidoglutaroyl Succinimide as "permitted". Safety rating: MODERATE.

Is Methoxy PEG-450 Amidoglutaroyl Succinimide allowed in the EU?

Methoxy PEG-450 Amidoglutaroyl Succinimide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Methoxy PEG-450 Amidoglutaroyl Succinimide do in cosmetics?

Methoxy PEG-450 Amidoglutaroyl Succinimide functions as: Hair conditioning (based on structural analogy to #7 and COSMILE Europe listing). It is classified as a cosmetic ingredient in our database. CAS number: Not confirmed from databases accessed.

What is the Margin of Safety for Methoxy PEG-450 Amidoglutaroyl Succinimide?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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