Regulatory Status
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Safety Data
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Expert Verdict
Maleimide is a reactive electrophile - unreacted maleimide groups could be skin sensitizers; must ensure proper conjugation in finished product; molecular weight ~20,000 Da limits skin penetration. Selective for thiol groups on cysteine side chains at pH 5.0-6.5; designed for PEGylation chemistry enabling durable attachment to hair proteins; molecular weight ~20,000 Da (number average)
Regulatory Flags
Frequently Asked Questions
Is Methoxy PEG-450 Maleimide safe in cosmetics?
Maleimide is a reactive electrophile - unreacted maleimide groups could be skin sensitizers; must ensure proper conjugation in finished product; molecular weight ~20,000 Da limits skin penetration. Selective for thiol groups on cysteine side chains at pH 5.0-6.5; designed for PEGylation chemistry enabling durable attachment to hair proteins; molecular weight ~20,000 Da (number average) The EU classifies Methoxy PEG-450 Maleimide as "permitted". Safety rating: MODERATE.
Is Methoxy PEG-450 Maleimide allowed in the EU?
Methoxy PEG-450 Maleimide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Methoxy PEG-450 Maleimide do in cosmetics?
Methoxy PEG-450 Maleimide functions as: Hair conditioning, protein conjugation agent (maleimide group is thiol-reactive, binds to cysteine residues in keratin). It is classified as a cosmetic ingredient in our database. CAS number: General mPEG-maleimide CAS: 99126-64-4 (covers various MW); specific CAS for the 450 EO unit variant not separately confirmed.
What is the Margin of Safety for Methoxy PEG-450 Maleimide?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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