NOAEL Studies
Cosmetic Ingredient
Methyl Anthranilate NOAEL Studies
INCI: METHYL ANTHRANILATE
CAS: 134-20-3
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS DB 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS DB | NOAEL | 500 | mg/kg bw/day | rat | oral | 90 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
EFSA 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA | NOAEL | =150 | mg/kg bw/day | Rat | - | 90 days | subchronic | EFSA FEEDAP - 2011 - OutputID 146 - systemic - Scientific Opinion on the safety and efficacy of anthranilate derivatives (chemical group 27) when used as flavourings for all animal species - doi:10.2903/j.efsa.2011.2441 |
| EFSA | NOEL | =150 | mg/kg bw/day | Rat | oral: feed | 115 days | chronic/long term toxicity | EFSA AFC - 2008 - OutputID 2284 - Flavouring Group Evaluation 84, (FGE.84). Consideration of Anthranilate derivatives evaluated by JECFA (65th meeting). Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food - doi:10.2903/j.efsa.2008.856 |
| EFSA | NOAEL | =150 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=EFSA FEEDAP (2011). Scientific Opinion on the safety and efficacy of anthranilate derivatives (chemical group 27) when used as flavourings for all animal species. doi:10.2903/j.efsa.2011.2441.; TITLE=Scientific Opinion on the safety and efficacy of anthranilate derivatives (chemical group 27) when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2011.2441; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=EFSA:15614115:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7747794062fe636f7772a15c55bee0fd |
| EFSA | NOEL | =150 | mg/kg bw/day | Rat | oral | chronic; 115 days | chronic | LONG_REF=EFSA AFC (2008). Flavouring Group Evaluation 84, (FGE.84). Consideration of Anthranilate derivatives evaluated by JECFA (65th meeting). Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food. doi:10.2903/j.efsa.2008.856.; TITLE=Flavouring Group Evaluation 84, (FGE.84). Consideration of Anthranilate derivatives evaluated by JECFA (65th meeting). Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food; AUTHOR=EFSA AFC; DOI=doi:10.2903/j.efsa.2008.856; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2008; ORIGINAL_YEAR=2008; STUDY_GROUP=EFSA:15614116:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c4725f731ef9d4db338f91d2d8769932 |
NTP ICE acute oral 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | =2910 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_2325; row=10400; data_type=In Vivo; mixture=Chemical; chemical_name=Methyl 2-aminobenzoate; preferred_name=Methyl 2-aminobenzoate; dtxsid=DTXSID6025567; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025567; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6025567; source_file=acute_oral.xlsx |
NTP ICE adme parameters 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE adme parameters | Clint | 246 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=2524; Record_ID=adme_parameters_1039; Data_Type=Measured; DTXSID=DTXSID6025567; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=246.0; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025567; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025567 |
| NTP ICE adme parameters | Fu | 0.224 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=2525; Record_ID=adme_parameters_1039; Data_Type=Measured; DTXSID=DTXSID6025567; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.224; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025567; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025567 |
NTP ICE endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=11414; RecordID=ARPathway2016_796; DatasetName=ARPathway2016; DTXSID=DTXSID6025567; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025567; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025567 |
NTP ICE skin sensitization 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4817; Record_ID=skin_sensitization_invivo_1154; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6025567; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Epstein 1973: report to RIFM|RIFM 1973; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1974; Not available; 10.1016/0015-6264(74)90192-8; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025567; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025567 |
| NTP ICE skin sensitization | Induction dose per skin area | 6480 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4816; Record_ID=skin_sensitization_invivo_1154; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6025567; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=6480; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Epstein 1973: report to RIFM|RIFM 1973; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1974; Not available; 10.1016/0015-6264(74)90192-8; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025567; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025567 |
| NTP ICE skin sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4820; Record_ID=skin_sensitization_invivo_1154; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6025567; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Epstein 1973: report to RIFM|RIFM 1973; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1974; Not available; 10.1016/0015-6264(74)90192-8; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025567; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025567 |
ECHA 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | NOAEC | <1000 | mg/m3 | Rat | inhalation | subchronic; 90 days | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61fe3e4b096bca877f392; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17637/7/6/3?documentUUID=28b8894e-5e5b-49ab-b0a6-fdf702a5ced2; YEAR=1970; ORIGINAL_YEAR=1970; STUDY_GROUP=ECHA IUCLID:15827130:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2d7b9556328ec5772c342daa9c11c8d4 |
ToxValDB ECOTOX 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | LOEL | =1 | % w/v | Mouse | oral | acute; 1 days | acute | LONG_REF=J. Chem. Ecol.19(3): 427-432 Nolte,D.L., J.R. Mason, and L. Clark Avoidance of Bird Repellents by Mice (Mus musculus ) 1993; TITLE=Avoidance of Bird Repellents by Mice (Mus musculus ); AUTHOR=Nolte,D.L., J.R. Mason, and L. Clark; DOI=10.1007/BF00994315; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=152625; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Feeding behavior: Water consumption; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=ECOTOX:15610095:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=37be0b8a39a836a15f479701898b5c5b |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =49.3 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15633299:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2371e3a28281d8bec77e0243b6453151 |
WHO/JECFA 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| WHO/JECFA | ADI | <=1.5 | mg/kg | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650af2d9e4b0d99f5a86ff35; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/1915; YEAR=2005; ORIGINAL_YEAR=2005; STUDY_GROUP=WHO JECFA ADI:15715248:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_69817a3f28c133c164b86e1e65592f24 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 981I0C1E5W | UNII | - | - | - | chemical | - |