NOAEL Studies Cosmetic Ingredient

Methyl Anthranilate NOAEL Studies

INCI: METHYL ANTHRANILATE

CAS: 134-20-3

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 500 mg/kg bw/day rat oral 90 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =150 mg/kg bw/day Rat - 90 days subchronic EFSA FEEDAP - 2011 - OutputID 146 - systemic - Scientific Opinion on the safety and efficacy of anthranilate derivatives (chemical group 27) when used as flavourings for all animal species - doi:10.2903/j.efsa.2011.2441
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =150 mg/kg bw/day Rat - 90 days subchronic EFSA FEEDAP - 2011 - OutputID 146 - systemic - Scientific Opinion on the safety and efficacy of anthranilate derivatives (chemical group 27) when used as flavourings for all animal species - doi:10.2903/j.efsa.2011.2441
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOEL =150 mg/kg bw/day Rat oral: feed 115 days chronic/long term toxicity EFSA AFC - 2008 - OutputID 2284 - Flavouring Group Evaluation 84, (FGE.84). Consideration of Anthranilate derivatives evaluated by JECFA (65th meeting). Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food - doi:10.2903/j.efsa.2008.856
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOEL =150 mg/kg bw/day Rat oral: feed 115 days chronic/long term toxicity EFSA AFC - 2008 - OutputID 2284 - Flavouring Group Evaluation 84, (FGE.84). Consideration of Anthranilate derivatives evaluated by JECFA (65th meeting). Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food - doi:10.2903/j.efsa.2008.856
NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =2910 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_2325; row=10400; data_type=In Vivo; mixture=Chemical; chemical_name=Methyl 2-aminobenzoate; preferred_name=Methyl 2-aminobenzoate; dtxsid=DTXSID6025567; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025567; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6025567; source_file=acute_oral.xlsx
NTP_ICE_adme_parameters 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_adme_parameters Clint 246 uL/min/10^6 cells Human - - Measured; httk, Human Hepatic Intrinsic Clearance sheet=Data; excel_row=2524; Record_ID=adme_parameters_1039; Data_Type=Measured; DTXSID=DTXSID6025567; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=246.0; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025567; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025567
NTP_ICE_adme_parameters Fu 0.224 fraction Human - - Measured; httk, Human Plasma Fraction Unbound sheet=Data; excel_row=2525; Record_ID=adme_parameters_1039; Data_Type=Measured; DTXSID=DTXSID6025567; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.224; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025567; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025567
NTP_ICE_endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=11414; RecordID=ARPathway2016_796; DatasetName=ARPathway2016; DTXSID=DTXSID6025567; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025567; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025567
NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=4817; Record_ID=skin_sensitization_invivo_1154; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6025567; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Epstein 1973: report to RIFM|RIFM 1973; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1974; Not available; 10.1016/0015-6264(74)90192-8; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025567; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025567
NTP_ICE_skin_sensitization Induction dose per skin area 6480 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=4816; Record_ID=skin_sensitization_invivo_1154; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6025567; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=6480; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Epstein 1973: report to RIFM|RIFM 1973; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1974; Not available; 10.1016/0015-6264(74)90192-8; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025567; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025567
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=4820; Record_ID=skin_sensitization_invivo_1154; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6025567; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Epstein 1973: report to RIFM|RIFM 1973; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1974; Not available; 10.1016/0015-6264(74)90192-8; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025567; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025567
ToxValDB_ECHA_IUCLID 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEC <1000 mg/m3 Rat inhalation subchronic; 90 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61fe3e4b096bca877f392; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17637/7/6/3?documentUUID=28b8894e-5e5b-49ab-b0a6-fdf702a5ced2; YEAR=1970; ORIGINAL_YEAR=1970; STUDY_GROUP=ECHA IUCLID:15827130:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2d7b9556328ec5772c342daa9c11c8d4
ToxValDB_ECOTOX 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECOTOX LOEL =1 % w/v Mouse oral acute; 1 days acute LONG_REF=J. Chem. Ecol.19(3): 427-432 Nolte,D.L., J.R. Mason, and L. Clark Avoidance of Bird Repellents by Mice (Mus musculus ) 1993; TITLE=Avoidance of Bird Repellents by Mice (Mus musculus ); AUTHOR=Nolte,D.L., J.R. Mason, and L. Clark; DOI=10.1007/BF00994315; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=152625; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Feeding behavior: Water consumption; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=ECOTOX:15610095:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=37be0b8a39a836a15f479701898b5c5b
ToxValDB_EFSA 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA NOAEL =150 mg/kg bw/day Rat oral subchronic; 90 days subchronic LONG_REF=EFSA FEEDAP (2011). Scientific Opinion on the safety and efficacy of anthranilate derivatives (chemical group 27) when used as flavourings for all animal species. doi:10.2903/j.efsa.2011.2441.; TITLE=Scientific Opinion on the safety and efficacy of anthranilate derivatives (chemical group 27) when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2011.2441; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=EFSA:15614115:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7747794062fe636f7772a15c55bee0fd
ToxValDB_EFSA NOEL =150 mg/kg bw/day Rat oral chronic; 115 days chronic LONG_REF=EFSA AFC (2008). Flavouring Group Evaluation 84, (FGE.84). Consideration of Anthranilate derivatives evaluated by JECFA (65th meeting). Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food. doi:10.2903/j.efsa.2008.856.; TITLE=Flavouring Group Evaluation 84, (FGE.84). Consideration of Anthranilate derivatives evaluated by JECFA (65th meeting). Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food; AUTHOR=EFSA AFC; DOI=doi:10.2903/j.efsa.2008.856; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2008; ORIGINAL_YEAR=2008; STUDY_GROUP=EFSA:15614116:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c4725f731ef9d4db338f91d2d8769932
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =49.3 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15633299:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2371e3a28281d8bec77e0243b6453151
ToxValDB_WHO_JECFA_ADI 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_WHO_JECFA_ADI ADI <=1.5 mg/kg Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650af2d9e4b0d99f5a86ff35; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/1915; YEAR=2005; ORIGINAL_YEAR=2005; STUDY_GROUP=WHO JECFA ADI:15715248:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_69817a3f28c133c164b86e1e65592f24
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 981I0C1E5W UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H9NO2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"981I0C1E5W"}
openFDA substances FDA UNII substance identifier 981I0C1E5W UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H9NO2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"981I0C1E5W"}
openFDA substances FDA UNII substance identifier 981I0C1E5W UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H9NO2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"981I0C1E5W"}
openFDA substances FDA UNII substance identifier 981I0C1E5W UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H9NO2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"981I0C1E5W"}