Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for Methyl Anthranilate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 500 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| dose_tested | 500 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 150 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Methyl Anthranilate is one of the safest fragrance ingredients by margin of safety, with MOEs exceeding 384,000. Extensively tested with no genotoxicity, no sensitization in multiple assays, and no phototoxicity or photoallergenicity.
Regulatory Flags
Frequently Asked Questions
Is Methyl Anthranilate safe in cosmetics?
Methyl Anthranilate is one of the safest fragrance ingredients by margin of safety, with MOEs exceeding 384,000. Extensively tested with no genotoxicity, no sensitization in multiple assays, and no phototoxicity or photoallergenicity. The EU classifies Methyl Anthranilate as "permitted". Safety rating: EXCELLENT. 4 toxicological study endpoint(s) are available in our database.
Is Methyl Anthranilate allowed in the EU?
Methyl Anthranilate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Methyl Anthranilate do in cosmetics?
Methyl Anthranilate functions as: Fragrance. It is classified as a Cosmetic Ingredient in our database. CAS number: 134-20-3.
What is the Margin of Safety for Methyl Anthranilate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Methyl Anthranilate?
The NOAEL (No Observed Adverse Effect Level) for Methyl Anthranilate is 500 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 4 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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