Moderate Cosmetic Ingredient Sensitization Data

Methyl Cinnamate

INCI: METHYL CINNAMATE

CAS Number
103-26-4
Function
Fragrance ingredient
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status restricted
🇺🇸 US Status permitted
US Notes Permitted — GRAS for food (FEMA); not specifically restricted under 21 CFR for cosmetics

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Sensitization Profile

Contact sensitization data for Methyl Cinnamate based on clinical patch test studies and IFRA standards.

Sensitization Rate
low
Allergen Class
fragrance
EU Allergen Listed
yes
Patch Test Positive Rate
0.2%
Cross-reactivity Group
balsam-of-peru-group
Reaction Type
contact-dermatitis
IFRA Restricted

Source: EU 2023/1545; SCCS/1459/11

Expert Verdict

Key concern: skin sensitization. H317 classification requires risk management in formulation. IFRA restricts use levels by product category. Not currently one of the 26 Annex III allergens, but methyl cinnamate derivatives are under scrutiny and require individual QRA if used above trace levels.

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Concern Level: Moderate

Regulatory Flags

potential-allergen fragrance-component ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is Methyl Cinnamate safe in cosmetics?

Key concern: skin sensitization. H317 classification requires risk management in formulation. IFRA restricts use levels by product category. Not currently one of the 26 Annex III allergens, but methyl cinnamate derivatives are under scrutiny and require individual QRA if used above trace levels. The EU classifies Methyl Cinnamate as "restricted". Safety rating: MODERATE.

Is Methyl Cinnamate allowed in the EU?

Methyl Cinnamate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Methyl Cinnamate do in cosmetics?

Methyl Cinnamate functions as: Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 103-26-4.

What is the Margin of Safety for Methyl Cinnamate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Methyl Cinnamate compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
 🧪
Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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