Moderate Cosmetic Ingredient NOAEL Data

Methyl Hexyl Cyclopentanone Carboxylate

INCI: METHYL HEXYL CYCLOPENTANONE CARBOXYLATE

CAS Number
37172-53-5
Function
Fragrance / Perfuming
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Allowed - listed on EPA TSCA inventory; no specific FDA prohibition

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

4 study endpoints found for Methyl Hexyl Cyclopentanone Carboxylate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL >=100 mg/kg bw/day oral rat oral REACH
NOAEL >1000 mg/kg bw/day oral rat oral REACH
NOAEL >=100 mg/kg bw/day oral - oral REACH
NOAEL >1000 mg/kg bw/day oral rat oral REACH

Expert Verdict

Generally considered safe; does not meet GHS hazard criteria per 92.3% of ECHA notifications; RIFM safety-assessed. Jasmine-like floral scent profile (dihydrojasmonate); widely used in fine fragrance and functional perfumery; found in over 100 consumer products

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Concern Level: Moderate

Regulatory Flags

fragrance-component ifra_fragrance

Frequently Asked Questions

Is Methyl Hexyl Cyclopentanone Carboxylate safe in cosmetics?

Generally considered safe; does not meet GHS hazard criteria per 92.3% of ECHA notifications; RIFM safety-assessed. Jasmine-like floral scent profile (dihydrojasmonate); widely used in fine fragrance and functional perfumery; found in over 100 consumer products The EU classifies Methyl Hexyl Cyclopentanone Carboxylate as "permitted". Safety rating: MODERATE. 4 toxicological study endpoint(s) are available in our database.

Is Methyl Hexyl Cyclopentanone Carboxylate allowed in the EU?

Methyl Hexyl Cyclopentanone Carboxylate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Methyl Hexyl Cyclopentanone Carboxylate do in cosmetics?

Methyl Hexyl Cyclopentanone Carboxylate functions as: Fragrance / Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 37172-53-5.

What is the Margin of Safety for Methyl Hexyl Cyclopentanone Carboxylate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Methyl Hexyl Cyclopentanone Carboxylate?

The NOAEL (No Observed Adverse Effect Level) for Methyl Hexyl Cyclopentanone Carboxylate is >=100 mg/kg bw/day based on a oral study via oral route in rat. A total of 4 study endpoints are available. Source: REACH.

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