Excellent Cosmetic Ingredient NOAEL Data

Methyl Myristate

INCI: METHYL MYRISTATE

CAS Number
124-10-7
Function
Fragrance agent, emollient, skin conditioning agent
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” CIR Expert Panel reviewed myristic acid esters and found them safe as used

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Methyl Myristate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 1000 mg/kg bw/day oral rat oral REACH

Expert Verdict

Minimal irritation risk at normal use levels. May cause mild skin irritation at high concentrations; toxic to aquatic life (GHS H410) โ€” relevant for rinse-off products.

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Concern Level: Low

Regulatory Flags

fragrance-component ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is Methyl Myristate safe in cosmetics?

Minimal irritation risk at normal use levels. May cause mild skin irritation at high concentrations; toxic to aquatic life (GHS H410) โ€” relevant for rinse-off products. The EU classifies Methyl Myristate as "permitted". Safety rating: EXCELLENT. 1 toxicological study endpoint(s) are available in our database.

Is Methyl Myristate allowed in the EU?

Methyl Myristate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Methyl Myristate do in cosmetics?

Methyl Myristate functions as: Fragrance agent, emollient, skin conditioning agent. It is classified as a cosmetic ingredient in our database. CAS number: 124-10-7.

What is the Margin of Safety for Methyl Myristate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Methyl Myristate?

The NOAEL (No Observed Adverse Effect Level) for Methyl Myristate is 1000 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.

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