Methyl N-Methylanthranilate
INCI: METHYL N-METHYLANTHRANILATE (ALSO: METHYL 2-(METHYLAMINO)BENZOATE)
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Methyl N-Methylanthranilate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 120 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 20.3 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| dose_tested | 20.3 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | ca.21 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 100 mg/kg bw/day | dermal | code:3544 | dermal | REACH |
| NOAEL | ca.20 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 500 mg/kg bw/day | dermal | code:3484 | dermal | REACH |
| NOAEL | 19.9 other | oral | rat | oral | REACH |
| NOAEL | 506.700012207 mg/kg bw/day | dermal | code:3484 | dermal | REACH |
| NOEL | 162.519241333 2106 | 1991 | rat | inhalation | REACH |
Expert Verdict
Phototoxic - the SCCS (Opinion SCCS/1455/11) confirmed risks when applied to sun-exposed skin. Not safe for sunscreen products or cosmetics applied to light-exposed body surfaces at unrestricted levels. Nitrosamine formation potential when combined with nitrosating agents. Grape-like, fruity-floral scent character; historically used unrestricted until EU regulation in 2022; UK Cosmetics Regulation does not yet regulate it separately
Regulatory Flags
Frequently Asked Questions
Is Methyl N-Methylanthranilate safe in cosmetics?
Phototoxic - the SCCS (Opinion SCCS/1455/11) confirmed risks when applied to sun-exposed skin. Not safe for sunscreen products or cosmetics applied to light-exposed body surfaces at unrestricted levels. Nitrosamine formation potential when combined with nitrosating agents. Grape-like, fruity-floral scent character; historically used unrestricted until EU regulation in 2022; UK Cosmetics Regulation does not yet regulate it separately The EU classifies Methyl N-Methylanthranilate as "restricted". Safety rating: MODERATE. 10 toxicological study endpoint(s) are available in our database.
Is Methyl N-Methylanthranilate allowed in the EU?
Methyl N-Methylanthranilate EU regulatory status: restricted. Maximum allowed concentration: 0.1%. This is based on EU Regulation 1223/2009 and its amendments.
What does Methyl N-Methylanthranilate do in cosmetics?
Methyl N-Methylanthranilate functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 85-91-6.
What is the Margin of Safety for Methyl N-Methylanthranilate?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Methyl N-Methylanthranilate?
The NOAEL (No Observed Adverse Effect Level) for Methyl N-Methylanthranilate is 120 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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