Tetrahydro-6-pent-2-enyl-pyran-2-one (Massoia Lactone)

INCI: LISTED AS FRAGRANCE COMPONENT; COMMONLY CALLED MASSOIA LACTONE (Δ-DECENOLACTONE, 6-PENTYL-5,6-DIHYDROPYRAN-2-ONE)

CAS Number
54814-64-1 (racemic); 51154-96-2 (R-isomer)
Function
Fragrance ingredient; FEMA GRAS 3744 (flavor use)
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes FEMA GRAS 3744; permitted in flavors and fragrances

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

α,β-unsaturated lactone — electrophilic Michael acceptor mechanism creates sensitization risk; IFRA concentration limits apply; verify compliance with IFRA 50th Amendment standards; natural source (Massoia bark oil) may contain variable lactone levels

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Concern Level: Moderate

Regulatory Flags

potential-allergen fragrance-component natural-origin

Frequently Asked Questions

Is Tetrahydro-6-pent-2-enyl-pyran-2-one (Massoia Lactone) safe in cosmetics?

α,β-unsaturated lactone — electrophilic Michael acceptor mechanism creates sensitization risk; IFRA concentration limits apply; verify compliance with IFRA 50th Amendment standards; natural source (Massoia bark oil) may contain variable lactone levels The EU classifies Tetrahydro-6-pent-2-enyl-pyran-2-one (Massoia Lactone) as "permitted". Safety rating: MODERATE.

Is Tetrahydro-6-pent-2-enyl-pyran-2-one (Massoia Lactone) allowed in the EU?

Tetrahydro-6-pent-2-enyl-pyran-2-one (Massoia Lactone) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Tetrahydro-6-pent-2-enyl-pyran-2-one (Massoia Lactone) do in cosmetics?

Tetrahydro-6-pent-2-enyl-pyran-2-one (Massoia Lactone) functions as: Fragrance ingredient; FEMA GRAS 3744 (flavor use). It is classified as a cosmetic ingredient in our database. CAS number: 54814-64-1 (racemic); 51154-96-2 (R-isomer).

What is the Margin of Safety for Tetrahydro-6-pent-2-enyl-pyran-2-one (Massoia Lactone)?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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