Methyl Propyl Diketone

INCI: METHYL PROPYL DIKETONE

CAS Number
3848-24-6 (2,3-hexanedione)
Function
Fragrance (parfuming agent)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Allowed - not on the FDA prohibited/restricted list; manufacturer bears responsibility for safety substantiation

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Potential respiratory sensitization at high occupational exposure levels; associated with diacetyl-type bronchiolitis obliterans ("popcorn lung") in industrial inhalation settings. IFRA guidelines may apply for use levels in fragrances. Synthetic origin; buttery/creamy odor profile; structurally related to diacetyl

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Concern Level: Moderate

Regulatory Flags

potential-allergen fragrance-component

Frequently Asked Questions

Is Methyl Propyl Diketone safe in cosmetics?

Potential respiratory sensitization at high occupational exposure levels; associated with diacetyl-type bronchiolitis obliterans ("popcorn lung") in industrial inhalation settings. IFRA guidelines may apply for use levels in fragrances. Synthetic origin; buttery/creamy odor profile; structurally related to diacetyl The EU classifies Methyl Propyl Diketone as "restricted". Safety rating: MODERATE.

Is Methyl Propyl Diketone allowed in the EU?

Methyl Propyl Diketone EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Methyl Propyl Diketone do in cosmetics?

Methyl Propyl Diketone functions as: Fragrance (parfuming agent). It is classified as a cosmetic ingredient in our database. CAS number: 3848-24-6 (2,3-hexanedione).

What is the Margin of Safety for Methyl Propyl Diketone?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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