NOAEL Studies Fragrance

Methyl Salicylate NOAEL Studies

INCI: METHYL SALICYLATE

CAS: 119-36-8

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 7 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
COSMOS DB	LOAEL	150	mg/kg bw/day	dog	oral	225 day	Subchronic	PAFA;REACH; FAP
COSMOS DB	LOAEL	250	mg/kg bw/day	rat	oral	2 year	Chronic	REACH; Toxicology and Applied Pharmacology 5: 576-687
COSMOS DB	NOAEL	50	mg/kg bw/day	dog	oral	2 day	Chronic	REACH; Toxicology and Applied Pharmacology 5: 576-687
COSMOS DB	NOAEL	100	mg/kg bw/day	mouse	oral	NA	Multigeneration Reproductive	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB	NOAEL	150	mg/kg bw/day	dog	oral	225 day	Chronic	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB	NOAEL	167	mg/kg bw/day	dog	oral	180 day	Chronic	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB	NOAEL	250	mg/kg bw/day	rat	oral	NA	Multigeneration Reproductive	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study

EFSA 1 endpoint

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
EFSA	NOAEL	=50	mg/kg bw/day	Dog	-	730 days	chronic/long term toxicity	EFSA AFC - 2008 - OutputID 2243 - Flavouring Group Evaluation 52 (FGE.52): Consideration of hydroxy- and alkoxy substituted benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters evaluated by EFSA in FGE.20 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - doi:10.2903/j.efsa.2008.637

NTP ICE acute oral 2 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
NTP ICE acute oral	LD50	=887	mg/kg bw	Rat	oral	acute	Rat Acute Oral Toxicity	NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1579; row=8909; data_type=In Vivo; mixture=Chemical; chemical_name=Methyl salicylate; preferred_name=Methyl salicylate; dtxsid=DTXSID5025659; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5025659; source_file=acute_oral.xlsx
NTP ICE acute oral	LD50	=2820	mg/kg bw	Rat	oral	acute	Rat Acute Oral Toxicity	ECHA ChemProp (undated); record_id=acute_oral_1582; row=8910; data_type=In Vivo; mixture=Chemical; chemical_name=Methyl salicylate; preferred_name=Methyl salicylate; dtxsid=DTXSID5025659; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5025659; source_file=acute_oral.xlsx

NTP ICE adme parameters 2 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
NTP ICE adme parameters	Clint	817	uL/min/10^6 cells	Human	-	-	Measured; httk, Human Hepatic Intrinsic Clearance	sheet=Data; excel_row=2090; Record_ID=adme_parameters_1047; Data_Type=Measured; DTXSID=DTXSID5025659; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=817.0; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE adme parameters	Fu	0.107	fraction	Human	-	-	Measured; httk, Human Plasma Fraction Unbound	sheet=Data; excel_row=2089; Record_ID=adme_parameters_1047; Data_Type=Measured; DTXSID=DTXSID5025659; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.107; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659

NTP ICE endocrine 1 endpoint

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
NTP ICE endocrine	Model Score	0	unitless	-	-	-	ARPathway2016; AR Pathway Model, Antagonist	sheet=Integrated_approaches; excel_row=11526; RecordID=ARPathway2016_657; DatasetName=ARPathway2016; DTXSID=DTXSID5025659; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659

NTP ICE skin sensitization 71 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
NTP ICE skin sensitization	CD86, EC150	>200	ug/mL	-	Dermal	-	In Vitro; CE_USENSE2018; U-SENS	sheet=Data_invitro; excel_row=8735; Record_ID=skin_sensitization_invitro_2421; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=U-SENS; Endpoint=CD86, EC150; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=200; Reported_Response_Unit=ug/mL; Response=200; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	CD86, EC150	>1065.043	ug/mL	-	Dermal	-	In Vitro; Urbisch_SkinSensitization2020; U-SENS	sheet=Data_invitro; excel_row=8190; Record_ID=skin_sensitization_invitro_2213; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=U-SENS; Endpoint=CD86, EC150; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=7000; Reported_Response_Unit=uM; Conversion_Factor_Value=152.149; Conversion_Factor_Source=EPA Dashboard; Converted_Response_Modifier=>; Converted_Response=1065.043; Converted_Response_Unit=ug/mL; Response=1065.043; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	CV75	95	ug/mL	-	Dermal	-	In Vitro; hCLAT2015; h-CLAT	sheet=Data_invitro; excel_row=3018; Record_ID=skin_sensitization_invitro_696; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=h-CLAT; Endpoint=CV75; Reported_Response=95; Reported_Response_Unit=ug/mL; Response=95; Response_Unit=ug/mL; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030\|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	CV75	542.4	ug/mL	-	Dermal	-	In Vitro; CE_hCLAT2018; h-CLAT	sheet=Data_invitro; excel_row=2259; Record_ID=skin_sensitization_invitro_554; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=h-CLAT; Endpoint=CV75; Reported_Response=542.4; Reported_Response_Unit=ug/mL; Response=542.4; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Depletion Cys	-2.4	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=834; Record_ID=skin_sensitization_invitro_232; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=-2.4; Reported_Response_Unit=%; Response=-2.4; Response_Unit=%; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030\|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Depletion Cys	0	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=826; Record_ID=skin_sensitization_invitro_230; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=0; Reported_Response_Unit=%; Response=0; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Depletion Cys	0.2	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=854; Record_ID=skin_sensitization_invitro_237; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=0.2; Reported_Response_Unit=%; Response=0.2; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Depletion Cys	0.3	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=822; Record_ID=skin_sensitization_invitro_229; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=0.3; Reported_Response_Unit=%; Response=0.3; Response_Unit=%; Reference=Gerberick et al. 2004; 15254333; 10.1093/toxsci/kfh213\|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Depletion Cys	0.4	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=830; Record_ID=skin_sensitization_invitro_231; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=0.4; Reported_Response_Unit=%; Response=0.4; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Depletion Cys	3.4	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=842; Record_ID=skin_sensitization_invitro_234; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=3.4; Reported_Response_Unit=%; Response=3.4; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Depletion Cys	9.1	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=838; Record_ID=skin_sensitization_invitro_233; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=9.1; Reported_Response_Unit=%; Response=9.1; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Depletion Cys	11.3	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=846; Record_ID=skin_sensitization_invitro_235; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=11.3; Reported_Response_Unit=%; Response=11.3; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Depletion Lys	-0.2	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=833; Record_ID=skin_sensitization_invitro_232; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=-0.2; Reported_Response_Unit=%; Response=-0.2; Response_Unit=%; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030\|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Depletion Lys	1	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=837; Record_ID=skin_sensitization_invitro_233; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=1; Reported_Response_Unit=%; Response=1; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Depletion Lys	1.3	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=849; Record_ID=skin_sensitization_invitro_236; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=1.3; Reported_Response_Unit=%; Response=1.3; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Depletion Lys	1.6	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=821; Record_ID=skin_sensitization_invitro_229; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=1.6; Reported_Response_Unit=%; Response=1.6; Response_Unit=%; Reference=Gerberick et al. 2004; 15254333; 10.1093/toxsci/kfh213\|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Depletion Lys	2.9	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=841; Record_ID=skin_sensitization_invitro_234; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=2.9; Reported_Response_Unit=%; Response=2.9; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Depletion Lys	3	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=845; Record_ID=skin_sensitization_invitro_235; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=3; Reported_Response_Unit=%; Response=3; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Depletion Lys	22.9	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=829; Record_ID=skin_sensitization_invitro_231; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=22.9; Reported_Response_Unit=%; Response=22.9; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Depletion Lys	24.4	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=825; Record_ID=skin_sensitization_invitro_230; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=24.4; Reported_Response_Unit=%; Response=24.4; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Depletion Lys	24.6	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=865; Record_ID=skin_sensitization_invitro_240; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=24.6; Reported_Response_Unit=%; Response=24.6; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Depletion Lys + Cys	0.7	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=859; Record_ID=skin_sensitization_invitro_238; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=0.7; Reported_Response_Unit=%; Response=0.7; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Depletion Lys + Cys	0.8	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=851; Record_ID=skin_sensitization_invitro_236; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=0.8; Reported_Response_Unit=%; Response=0.8; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Depletion Lys + Cys	0.9	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=855; Record_ID=skin_sensitization_invitro_237; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=0.9; Reported_Response_Unit=%; Response=0.9; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Depletion Lys + Cys	0.95	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=823; Record_ID=skin_sensitization_invitro_229; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=0.95; Reported_Response_Unit=%; Response=0.95; Response_Unit=%; Reference=Gerberick et al. 2004; 15254333; 10.1093/toxsci/kfh213\|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Depletion Lys + Cys	3.15	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=843; Record_ID=skin_sensitization_invitro_234; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=3.15; Reported_Response_Unit=%; Response=3.15; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Depletion Lys + Cys	5.05	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=839; Record_ID=skin_sensitization_invitro_233; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=5.05; Reported_Response_Unit=%; Response=5.05; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Depletion Lys + Cys	7.15	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=847; Record_ID=skin_sensitization_invitro_235; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=7.15; Reported_Response_Unit=%; Response=7.15; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Depletion Lys + Cys	11.65	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=831; Record_ID=skin_sensitization_invitro_231; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=11.65; Reported_Response_Unit=%; Response=11.65; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Depletion Lys + Cys	12.2	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=827; Record_ID=skin_sensitization_invitro_230; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=12.2; Reported_Response_Unit=%; Response=12.2; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Depletion Lys + Cys	12.8	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=867; Record_ID=skin_sensitization_invitro_240; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=12.8; Reported_Response_Unit=%; Response=12.8; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	EC1.5	80.98	uM	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=4827; Record_ID=skin_sensitization_invitro_1112; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=80.98; Reported_Response_Unit=uM; Response=80.98; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	EC1.5	228.87	uM	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=4824; Record_ID=skin_sensitization_invitro_1121; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=228.87; Reported_Response_Unit=uM; Response=228.87; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	EC1.5	508.18	uM	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=4825; Record_ID=skin_sensitization_invitro_1122; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=508.18; Reported_Response_Unit=uM; Response=508.18; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	EC1.5	<803.76	uM	-	Dermal	-	In Vitro; Urbisch_SkinSensitization2020; LuSens	sheet=Data_invitro; excel_row=7990; Record_ID=skin_sensitization_invitro_1806; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=LuSens; Endpoint=EC1.5; Response_Modifier=<; Reported_Response_Modifier=<; Reported_Response=803.76; Reported_Response_Unit=uM; Response=803.76; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	EC1.5	1076	uM	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=4818; Record_ID=skin_sensitization_invitro_1111; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=1075.8699999999999; Reported_Response_Unit=uM; Response=1076; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	EC1.5	1612	uM	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=4820; Record_ID=skin_sensitization_invitro_1118; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=1612; Reported_Response_Unit=uM; Response=1612; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	EC1.5	>2000	uM	-	Dermal	-	In Vitro; CE_KeratinoSense2018; KeratinoSens	sheet=Data_invitro; excel_row=4822; Record_ID=skin_sensitization_invitro_1116; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=KeratinoSens; Endpoint=EC1.5; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2000; Reported_Response_Unit=uM; Response=2000; Response_Unit=uM; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009\|Natsch et al. 2013; 23576290; 10.1002/jat.2868\|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	EC3	11.5	%	Mouse	Dermal	-	In Vivo; LLNAdb2013; LLNA	sheet=Data_invivo; excel_row=13464; Record_ID=skin_sensitization_invivo_3630; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=LLNA; Endpoint=EC3; Response=11.5; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Montelius et al. 1994; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	EC3	25	%	Mouse	Dermal	-	In Vivo; LLNAdb2013; LLNA	sheet=Data_invivo; excel_row=13462; Record_ID=skin_sensitization_invivo_3627; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=LLNA; Endpoint=EC3; Response=25; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Montelius et al. 1994; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	IC50	>2000	uM	-	Dermal	-	In Vitro; Urbisch_SkinSensitization2020; LuSens	sheet=Data_invitro; excel_row=7638; Record_ID=skin_sensitization_invitro_1806; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=LuSens; Endpoint=IC50; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2000; Reported_Response_Unit=uM; Response=2000; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Imax	1.198	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=4879; Record_ID=skin_sensitization_invitro_1120; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.198; Reported_Response_Unit=Unitless; Response=1.198; Response_Unit=Ratio; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009\|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Imax	1.2	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=4881; Record_ID=skin_sensitization_invitro_1131; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.2; Reported_Response_Unit=Unitless; Response=1.2; Response_Unit=Ratio; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009\|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Imax	1.202	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=4883; Record_ID=skin_sensitization_invitro_1124; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.202; Reported_Response_Unit=Unitless; Response=1.202; Response_Unit=Ratio; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009\|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Imax	1.22	ratio	-	Dermal	-	In Vitro; CE_KeratinoSense2018; KeratinoSens	sheet=Data_invitro; excel_row=4885; Record_ID=skin_sensitization_invitro_1116; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.22; Reported_Response_Unit=Unitless; Response=1.22; Response_Unit=Ratio; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009\|Natsch et al. 2013; 23576290; 10.1002/jat.2868\|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Imax	1.237	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=4887; Record_ID=skin_sensitization_invitro_1123; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.2370000000000001; Reported_Response_Unit=Unitless; Response=1.237; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Imax	1.344	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=4888; Record_ID=skin_sensitization_invitro_1125; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.3440000000000001; Reported_Response_Unit=Unitless; Response=1.344; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Imax	1.351	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=4890; Record_ID=skin_sensitization_invitro_1126; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.351; Reported_Response_Unit=Unitless; Response=1.351; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Imax	1.365	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=4892; Record_ID=skin_sensitization_invitro_1129; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.365; Reported_Response_Unit=Unitless; Response=1.365; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Imax	1.4	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=4894; Record_ID=skin_sensitization_invitro_1132; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.4; Reported_Response_Unit=Unitless; Response=1.4; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Imax	1.419	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=4896; Record_ID=skin_sensitization_invitro_1127; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.419; Reported_Response_Unit=Unitless; Response=1.419; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Imax	1.473	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=4898; Record_ID=skin_sensitization_invitro_1130; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.4730000000000001; Reported_Response_Unit=Unitless; Response=1.473; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Imax	1.475	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=4899; Record_ID=skin_sensitization_invitro_1128; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.4750000000000001; Reported_Response_Unit=Unitless; Response=1.475; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Imax	1.478	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=4900; Record_ID=skin_sensitization_invitro_1115; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.478; Reported_Response_Unit=Unitless; Response=1.478; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Imax	1.5	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=4901; Record_ID=skin_sensitization_invitro_1134; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.5; Reported_Response_Unit=Unitless; Response=1.5; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Imax	1.54	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=4907; Record_ID=skin_sensitization_invitro_1119; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.54; Reported_Response_Unit=Unitless; Response=1.54; Response_Unit=Ratio; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030\|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Imax	1.586	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=4908; Record_ID=skin_sensitization_invitro_1122; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.5860000000000001; Reported_Response_Unit=Unitless; Response=1.586; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Imax	1.615	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=4910; Record_ID=skin_sensitization_invitro_1117; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.615; Reported_Response_Unit=Unitless; Response=1.615; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Imax	1.623	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=4912; Record_ID=skin_sensitization_invitro_1112; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.623; Reported_Response_Unit=Unitless; Response=1.623; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Imax	1.705	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=4914; Record_ID=skin_sensitization_invitro_1118; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.7050000000000001; Reported_Response_Unit=Unitless; Response=1.705; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Imax	1.748	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=4916; Record_ID=skin_sensitization_invitro_1121; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.748; Reported_Response_Unit=Unitless; Response=1.748; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Imax	2.219	ratio	-	Dermal	-	In Vitro; Urbisch_SkinSensitization2020; LuSens	sheet=Data_invitro; excel_row=7540; Record_ID=skin_sensitization_invitro_1806; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=LuSens; Endpoint=Imax; Reported_Response=2.218990032; Reported_Response_Unit=Unitless; Response=2.219; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Imax	2.7	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=4919; Record_ID=skin_sensitization_invitro_1133; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=2.7; Reported_Response_Unit=Unitless; Response=2.7; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Imax	3.049	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=4921; Record_ID=skin_sensitization_invitro_1114; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=3.0489999999999999; Reported_Response_Unit=Unitless; Response=3.049; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Imax	3.548	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=4923; Record_ID=skin_sensitization_invitro_1111; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=3.548; Reported_Response_Unit=Unitless; Response=3.548; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Incidence of positive responses	0	%	Human	Dermal	-	In Vivo; HPPT2020WIP; Human Maximization Test	sheet=Data_invivo; excel_row=4179; Record_ID=skin_sensitization_invivo_1013; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Epstein 1973: report to RIFM\|RIFM 1973; https://www.rifm.org/rifm-science-database.php#gsc.tab=0\|Anonymous 1978; Not available; 10.1016/S0015-6264(78)80132-1; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Induction dose per skin area	968.8	ug/cm2	Human	Dermal	-	In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test	sheet=Data_invivo; excel_row=4184; Record_ID=skin_sensitization_invivo_1015; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.25; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=968.8; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1964; https://www.rifm.org/rifm-science-database.php#gsc.tab=0\|Belsito et al. 2007; 18022746; 10.1016/j.fct.2007.09.066\|Lapczynski et al. 2007; 18031908; 10.1016/j.fct.2007.09.053; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Induction dose per skin area	5184	ug/cm2	Human	Dermal	-	In Vivo; HPPT2020WIP; Human Maximization Test	sheet=Data_invivo; excel_row=4176; Record_ID=skin_sensitization_invivo_1013; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=5184; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Epstein 1973: report to RIFM\|RIFM 1973; https://www.rifm.org/rifm-science-database.php#gsc.tab=0\|Anonymous 1978; Not available; 10.1016/S0015-6264(78)80132-1; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Max stimulation index	2.7	ratio	Mouse	Dermal	-	In Vivo; LLNA2013; LLNA	sheet=Data_invivo; excel_row=12853; Record_ID=skin_sensitization_invivo_485; Data_Type=In Vivo; Internal_Data_Source=LLNA2013; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=LLNA; Endpoint=Max stimulation index; Response=2.7; Response_Unit=Ratio; Species=Mouse; Route=Dermal; Reference=ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Relative reliability score	3	unitless	Human	Dermal	-	In Vivo; HPPT2020WIP; Human Maximization Test	sheet=Data_invivo; excel_row=4183; Record_ID=skin_sensitization_invivo_1013; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Epstein 1973: report to RIFM\|RIFM 1973; https://www.rifm.org/rifm-science-database.php#gsc.tab=0\|Anonymous 1978; Not available; 10.1016/S0015-6264(78)80132-1; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659
NTP ICE skin sensitization	Relative reliability score	4	unitless	Human	Dermal	-	In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test	sheet=Data_invivo; excel_row=4190; Record_ID=skin_sensitization_invivo_1015; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.25; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5025659; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=4; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=RIFM 1964; https://www.rifm.org/rifm-science-database.php#gsc.tab=0\|Belsito et al. 2007; 18022746; 10.1016/j.fct.2007.09.066\|Lapczynski et al. 2007; 18031908; 10.1016/j.fct.2007.09.053; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025659; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025659

SCCS Opinion 25 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
SCCS Opinion	NOAEL	=0.5	mg/kg/day	dog	oral	2-year	reproductive toxicity	p.29
SCCS Opinion	NOAEL	=0.9	%	rat	oral	12 weeks	NOAEL study	p.40
SCCS Opinion	NOAEL	=2	%	-	dermal	3 years	dermal absorption	p.19
SCCS Opinion	NOAEL	=2.52	%	-	oral	6 years	NOAEL study	p.21
SCCS Opinion	NOAEL	=6	-	-	dermal	-	dermal absorption	p.19
SCCS Opinion	NOAEL	=8	-	-	oral	6 years	NOAEL study	p.19
SCCS Opinion	NOAEL	=31	-	-	inhalation	-	NOAEL study	p.57
SCCS Opinion	NOAEL	=34	-	-	oral	developmental	reproductive toxicity	p.47
SCCS Opinion	NOAEL	=50	mg/kg/day	dog	oral	2-year	reproductive toxicity	p.29
SCCS Opinion	NOAEL	=50	mg/kg bw/day	rat	-	chronic	NOAEL study	p.41
SCCS Opinion	NOAEL	=50	%	rat	oral	-	dermal absorption	p.56
SCCS Opinion	NOAEL	=50	mg/kg bw/day	-	oral	-	reproductive toxicity	p.15
SCCS Opinion	NOAEL	=50	%	rat	oral	6 years	dermal absorption	p.17
SCCS Opinion	NOAEL	<60	mg/kg bw/d	rat	oral	developmental	developmental toxicity	p.49
SCCS Opinion	NOAEL	<60	mg/kg bw/d	rat	oral	developmental	reproductive toxicity	p.16
SCCS Opinion	NOAEL	=75	mg/kg bw/day	rat	-	developmental	reproductive toxicity	p.48
SCCS Opinion	NOAEL	=75	mg/kg bw/d	rat	oral	3 years	NOAEL study	p.56
SCCS Opinion	NOAEL	=75	mg/kg	-	-	6 years	NOAEL study	p.58
SCCS Opinion	NOAEL	=75	mg/kg bw/d	rat	oral	developmental	developmental toxicity	p.16
SCCS Opinion	NOAEL	=100	mg/kg/day	rat	oral	developmental	reproductive toxicity	p.47
SCCS Opinion	NOAEL	=120	ppm	-	-	-	NOAEL study	p.41
SCCS Opinion	NOAEL	=120	ppm	-	oral	-	reproductive toxicity	p.15
SCCS Opinion	NOAEL	=250	mg/kg bw/day	rat	-	developmental	reproductive toxicity	p.48
SCCS Opinion	NOAEL	=1633	-	-	oral	-	NOAEL study	p.57
SCCS Opinion	NOAEL	=75000	-	-	oral	-	NOAEL study	p.19

ECHA 21 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ECHA	LEL	=1440	mg/kg bw/day	Mouse	oral	short-term; 14 days	short-term	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca26e4b0a7c65d2208c8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/19733/7/6/2?documentUUID=90a9c6a5-ac66-4269-ae02-5ea7eac1f9ec; YEAR=2003; ORIGINAL_YEAR=2003; STUDY_GROUP=ECHA IUCLID:15850469:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_fd542456f634aa274c22a48f9494c703
ECHA	LOAEL	=150	mg/kg bw/day	Rat	oral	-	reproduction developmental	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa64e4b0a7c65d1b5ab5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/19733/7/9/2?documentUUID=90a9c6a5-ac66-4269-ae02-5ea7eac1f9ec; YEAR=2003; ORIGINAL_YEAR=2003; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855154_15856670_15863175:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f6833eb1ae97026fb27ca5d6c1a39051
ECHA	LOAEL	<=390	mg/kg bw/day	Rat	oral	chronic; 2 years	chronic	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae65e4b0a7c65d1c8f62; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13593/7/6/2?documentUUID=b703ebdb-8235-470e-830d-33622f851a8f; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=gross pathology\|histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology\|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15843394_15845506_15849531:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e0d52aebc09d8ebc29b71a67380f40a7
ECHA	LOAEL	=1000	mg/kg bw/day	Rat	oral	subchronic; 11 weeks	subchronic	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacf9e4b0a7c65d1c1cd0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/19733/7/6/2?documentUUID=90a9c6a5-ac66-4269-ae02-5ea7eac1f9ec; YEAR=2003; ORIGINAL_YEAR=2003; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15833479_15846221_15850466:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_93c1d94c543fe5a8f7901cc7fad45a80
ECHA	LOAEL	~1080	mg/kg bw/day	Rat	oral	subchronic; 10 weeks	subchronic	QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacf9e4b0a7c65d1c1cc8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/19733/7/6/2?documentUUID=90a9c6a5-ac66-4269-ae02-5ea7eac1f9ec; YEAR=2003; ORIGINAL_YEAR=2003; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15829898_15844449_15850464_15850465:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9532b15e9d0ac947aca33e8a60849db1
ECHA	NOAEL	=3.9	mg/kg bw/day	Rat	oral	chronic; 17 weeks	chronic	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaec9e4b0a7c65d1cafdd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23278/7/6/2?documentUUID=da8d09a8-236b-4588-8c8b-906fd051ede5; YEAR=1980; ORIGINAL_YEAR=1980; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15844855_15850467:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_001dc74ed3b177e3504894f282990fb3
ECHA	NOAEL	=50	mg/kg bw/day	Rat	oral	chronic; 2 years	chronic	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacf9e4b0a7c65d1c1cde; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/19733/7/6/2?documentUUID=90a9c6a5-ac66-4269-ae02-5ea7eac1f9ec; YEAR=2003; ORIGINAL_YEAR=2003; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15843394_15845506_15849531:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3935f812974f96857be1e4431902908d
ECHA	NOAEL	~60	mg/kg bw/day	Rat	injection	-	reproduction developmental	QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d199e4b0a7c65d22f375; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/19733/7/9/3?documentUUID=90a9c6a5-ac66-4269-ae02-5ea7eac1f9ec; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=maternal: body weight and weight gain\|maternal: food consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight\|food and/or water consumption; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15822153_15822891:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_07663934999e2f203a59f983032f8675
ECHA	NOAEL	=75	mg/kg bw/day	Rat	oral	-	reproduction developmental	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa64e4b0a7c65d1b5ab5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/19733/7/9/2?documentUUID=90a9c6a5-ac66-4269-ae02-5ea7eac1f9ec; YEAR=2003; ORIGINAL_YEAR=2003; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855154_15856670_15863175:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9cd5d296278c0552edcece5ecf246c73
ECHA	NOAEL	>=78	mg/kg bw/day	Rat	oral	chronic; 2 years	chronic	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae65e4b0a7c65d1c8f62; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13593/7/6/2?documentUUID=b703ebdb-8235-470e-830d-33622f851a8f; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=body weight and weight gain\|clinical signs\|gross pathology\|haematology\|histopathology: neoplastic\|histopathology: non-neoplastic\|mortality\|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight\|cancer\|clinical signs\|gross pathology\|hematology\|mortality/survival\|nonneoplastic histopathology\|organ weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15843394_15845506_15849531:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_86215c1a529b925fb1dbb88bff864215
ECHA	NOAEL	=100	mg/kg bw/day	Rat	injection	-	developmental	QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d199e4b0a7c65d22f37f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/19733/7/9/3?documentUUID=90a9c6a5-ac66-4269-ae02-5ea7eac1f9ec; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=fetus: fetal/pup body weight changes\|fetus: external malformations\|fetus: skeletal malformations\|fetus: visceral malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15821594_15823189:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_307960d3e8400980a834d8ef2a03ae39
ECHA	NOAEL	=167	mg/kg bw/day	Dog	oral	chronic; 6 months	chronic	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaec9e4b0a7c65d1cafe4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23278/7/6/2?documentUUID=da8d09a8-236b-4588-8c8b-906fd051ede5; YEAR=1980; ORIGINAL_YEAR=1980; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15847336_15847530:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_fd5b7b2ea6053856cdd1fc94acd76299
ECHA	NOAEL	=180	mg/kg bw/day	Rat	oral	subchronic; 12 weeks	subchronic	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaec9e4b0a7c65d1cafc7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23278/7/6/2?documentUUID=da8d09a8-236b-4588-8c8b-906fd051ede5; YEAR=1980; ORIGINAL_YEAR=1980; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837592_15850468:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bf7f4f22a81bafd080cfd6434e4a2907
ECHA	NOAEL	=250	ppm	Dog	oral	subchronic; 59 days	subchronic	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaec9e4b0a7c65d1cafb1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23278/7/6/2?documentUUID=da8d09a8-236b-4588-8c8b-906fd051ede5; YEAR=1980; ORIGINAL_YEAR=1980; STUDY_GROUP=ECHA IUCLID:15831119:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_76e43cf0b596e7af01866d58f46b8eab
ECHA	NOAEL	=250	mg/kg bw/day	Rat	oral	-	reproduction developmental	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa64e4b0a7c65d1b5ab5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/19733/7/9/2?documentUUID=90a9c6a5-ac66-4269-ae02-5ea7eac1f9ec; YEAR=2003; ORIGINAL_YEAR=2003; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855154_15856670_15863175:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a2686a875f1a7e342ed4c92dbc6b0442
ECHA	NOAEL	=300	mg/kg bw/day	Dog	oral	short-term; 3 days	short-term	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca26e4b0a7c65d2208d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/19733/7/6/2?documentUUID=90a9c6a5-ac66-4269-ae02-5ea7eac1f9ec; YEAR=2003; ORIGINAL_YEAR=2003; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15840352_15842660:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_824605e5b68f075238c5fffde35f0fa1
ECHA	NOAEL	=450	mg/kg bw/day	Rat	oral	subchronic; 11 weeks	subchronic	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacf9e4b0a7c65d1c1cca; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/19733/7/6/2?documentUUID=90a9c6a5-ac66-4269-ae02-5ea7eac1f9ec; YEAR=2003; ORIGINAL_YEAR=2003; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15833479_15846221_15850466:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_696e8db4af108840dbdbcd6b9547d02d
ECHA	NOAEL	=500	mg/kg bw/day	Mouse	oral	-	reproduction developmental	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab47e4b0a7c65d1b98f0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23278/7/9/2?documentUUID=da8d09a8-236b-4588-8c8b-906fd051ede5; YEAR=1980; ORIGINAL_YEAR=1980; STUDY_GROUP=ECHA IUCLID:15860563:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_eb28c7b17438e1ed88cd53c4a877187f
ECHA	NOAEL	~864	mg/kg bw/day	Rat	oral	subchronic; 10 weeks	subchronic	QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacf9e4b0a7c65d1c1cc8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/19733/7/6/2?documentUUID=90a9c6a5-ac66-4269-ae02-5ea7eac1f9ec; YEAR=2003; ORIGINAL_YEAR=2003; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15829898_15844449_15850464_15850465:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4b2a66294645d2289a5cec7c6bbedd15
ECHA	NOEC	=8	mg/m3	Rat	inhalation	chronic; 4 months	chronic	QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/19733/7/6/3?documentUUID=90a9c6a5-ac66-4269-ae02-5ea7eac1f9ec; YEAR=2003; ORIGINAL_YEAR=2003; STUDY_GROUP=ECHA IUCLID:15828668:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0cd2e30ba3f78218e7e4ed7dde7ec723
ECHA	NOEC	=700	mg/m3	Rat	inhalation	short-term; 4 weeks	short-term	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/19733/7/6/3?documentUUID=90a9c6a5-ac66-4269-ae02-5ea7eac1f9ec; YEAR=2003; ORIGINAL_YEAR=2003; STUDY_GROUP=ECHA IUCLID:15827455:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c6bf09736ca1327983b113b181d32239

ToxValDB GESTIS DNEL 3 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ToxValDB GESTIS DNEL	DNEL systemic	=7.05	mg/m3	Human	inhalation	-	Toxicity Value	STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15633499_15633500_15633501:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3b935e4c79b6fcd475386e50ae31f4d9
ToxValDB GESTIS DNEL	DNEL systemic	=9.87	mg/m3	Human	inhalation	-	Toxicity Value	STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15633499_15633500_15633501:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b526a3bf60a475db4fbac3303362a007
ToxValDB GESTIS DNEL	DNEL systemic	=17.5	mg/m3	Human	inhalation	-	Toxicity Value	STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15633499_15633500_15633501:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f94df72fabb8220e3bcf1453aea71234

WHO/JECFA 1 endpoint

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
WHO/JECFA	ADI	<=0.5	mg/kg	Human	oral	-	Toxicity Value	STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650b0065e4b0d99f5a883833; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/341; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=WHO JECFA ADI:15715609:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9a8d1a62bddf57588e4d8403daf084c2

Regulatory source 28 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
Regulatory source	-	0.9	%	rat	oral	12 weeks	-	p.40
Regulatory source	-	2.52	%	-	oral	6 years	-	p.21
Regulatory source	-	8	-	-	oral	6 years	-	p.19
Regulatory source	-	8	-	-	oral	-	-	p.19
Regulatory source	-	31	-	-	inhalation	-	-	p.57
Regulatory source	-	50	mg/kg bw/day	rat	-	chronic	-	p.41
Regulatory source	-	75	mg/kg bw/d	rat	oral	3 years	-	p.56
Regulatory source	-	75	mg/kg	-	-	6 years	-	p.58
Regulatory source	-	75	mg/kg bw/d	rat	oral	6 years	-	p.17
Regulatory source	-	120	ppm	-	-	-	-	p.41
Regulatory source	-	120	ppm	-	oral	6 years	-	p.57
Regulatory source	-	1633	-	-	oral	-	-	p.57
Regulatory source	-	75000	-	-	oral	-	-	p.19
Regulatory source	dermal absorption	50	%	rat	oral	-	dermal absorption	p.56
Regulatory source	dermal absorption	50	%	rat	oral	6 years	dermal absorption	p.17
Regulatory source	developmental toxicity	<60	mg/kg bw/d	rat	oral	developmental	developmental toxicity	p.49
Regulatory source	developmental toxicity	75	mg/kg bw/d	rat	oral	developmental	developmental toxicity	p.61
Regulatory source	reproductive toxicity	0.5	mg/kg/day	dog	oral	2-year	reproductive toxicity	p.29
Regulatory source	reproductive toxicity	34	-	-	oral	developmental	reproductive toxicity	p.47
Regulatory source	reproductive toxicity	50	mg/kg/day	dog	oral	2-year	reproductive toxicity	p.29
Regulatory source	reproductive toxicity	50	mg/kg bw/day	human	oral	-	reproductive toxicity	p.42
Regulatory source	reproductive toxicity	50	mg/kg bw/day	-	oral	-	reproductive toxicity	p.61
Regulatory source	reproductive toxicity	<60	mg/kg bw/d	rat	oral	developmental	reproductive toxicity	p.61
Regulatory source	reproductive toxicity	75	mg/kg bw/day	rat	-	developmental	reproductive toxicity	p.48
Regulatory source	reproductive toxicity	100	mg/kg/day	rat	oral	developmental	reproductive toxicity	p.47
Regulatory source	reproductive toxicity	120	ppm	human	oral	-	reproductive toxicity	p.42
Regulatory source	reproductive toxicity	120	ppm	-	oral	-	reproductive toxicity	p.61
Regulatory source	reproductive toxicity	250	mg/kg bw/day	rat	-	developmental	reproductive toxicity	p.48

openFDA substances 1 endpoint

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
openFDA substances	FDA UNII substance identifier	LAV5U5022Y	UNII	-	-	-	chemical	-