Methyl Undecenoyl Leucinate

INCI: METHYL UNDECENOYL LEUCINATE

CAS Number
1246371-29-8
Function
Skin lightening / whitening agent (melanogenesis inhibitor via MC1R receptor antagonism)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Allowed as a cosmetic ingredient - no specific prohibition. However, if marketed with drug-level whitening claims, FDA may classify the product as a drug.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

In vitro and in vivo studies show favorable safety profile; also exhibits anti-inflammatory properties against UV-induced stimuli. As a relatively newer active, long-term safety data may be limited compared to established lightening agents.. Lipo-amino acid that competitively antagonizes alpha-MSH at the MC1R receptor, blocking downstream activation of tyrosinase, TRP1, TRP2/DCT, MITF, and POMC, thereby inhibiting melanin synthesis. Claimed to be more effective than kojic acid, arbutin, and h...

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Concern Level: Moderate

Frequently Asked Questions

Is Methyl Undecenoyl Leucinate safe in cosmetics?

In vitro and in vivo studies show favorable safety profile; also exhibits anti-inflammatory properties against UV-induced stimuli. As a relatively newer active, long-term safety data may be limited compared to established lightening agents.. Lipo-amino acid that competitively antagonizes alpha-MSH at the MC1R receptor, blocking downstream activation of tyrosinase, TRP1, TRP2/DCT, MITF, and POMC, thereby inhibiting melanin synthesis. Claimed to be more effective than kojic acid, arbutin, and h... The EU classifies Methyl Undecenoyl Leucinate as "permitted". Safety rating: MODERATE.

Is Methyl Undecenoyl Leucinate allowed in the EU?

Methyl Undecenoyl Leucinate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Methyl Undecenoyl Leucinate do in cosmetics?

Methyl Undecenoyl Leucinate functions as: Skin lightening / whitening agent (melanogenesis inhibitor via MC1R receptor antagonism). It is classified as a cosmetic ingredient in our database. CAS number: 1246371-29-8.

What is the Margin of Safety for Methyl Undecenoyl Leucinate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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