NOAEL Studies Cosmetic Ingredient

Methylene Di-t-Butylcresol NOAEL Studies

INCI: METHYLENE DI-T-BUTYLCRESOL

CAS: 119-47-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_adme_parameters 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_adme_parameters Clint 22.4 uL/min/10^6 cells Human - - Measured; httk, Human Hepatic Intrinsic Clearance sheet=Data; excel_row=1578; Record_ID=adme_parameters_829; Data_Type=Measured; DTXSID=DTXSID4020870; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=22.4; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020870
NTP_ICE_adme_parameters Fu 2.14e-8 fraction Human - - Measured; httk, Human Plasma Fraction Unbound sheet=Data; excel_row=1577; Record_ID=adme_parameters_829; Data_Type=Measured; DTXSID=DTXSID4020870; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=2.14e-08; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020870
NTP_ICE_endocrine 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine AC50 17.358300750473 uM - - - ARPathway2016; AR Pathway Model, Agonist sheet=Integrated_approaches; excel_row=1622; RecordID=ARPathway2016_33; DatasetName=ARPathway2016; DTXSID=DTXSID4020870; Assay=AR Pathway Model, Agonist; Endpoint=AC50; Response=17.358300750473; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020870
NTP_ICE_endocrine AC50 37.1817167700206 uM - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=1628; RecordID=ERPathway2016_484; DatasetName=ERPathway2016; DTXSID=DTXSID4020870; Assay=ER Pathway Model, Antagonist; Endpoint=AC50; Response=37.1817167700206; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020870
NTP_ICE_endocrine ACC 15.5923196284655 uM - - - ARPathway2016; AR Pathway Model, Agonist sheet=Integrated_approaches; excel_row=1623; RecordID=ARPathway2016_33; DatasetName=ARPathway2016; DTXSID=DTXSID4020870; Assay=AR Pathway Model, Agonist; Endpoint=ACC; Response=15.5923196284655; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020870
NTP_ICE_endocrine ACC 25.0286813999498 uM - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=1629; RecordID=ERPathway2016_484; DatasetName=ERPathway2016; DTXSID=DTXSID4020870; Assay=ER Pathway Model, Antagonist; Endpoint=ACC; Response=25.0286813999498; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020870
NTP_ICE_endocrine Model Score 0.234 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=1624; RecordID=ARPathway2016_33; DatasetName=ARPathway2016; DTXSID=DTXSID4020870; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0.234; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020870
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Agonist sheet=Integrated_approaches; excel_row=1625; RecordID=ARPathway2016_33; DatasetName=ARPathway2016; DTXSID=DTXSID4020870; Assay=AR Pathway Model, Agonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020870
NTP_ICE_endocrine Model Score 0.00113 unitless - - - ERPathway2016; ER Pathway Model, Agonist sheet=Integrated_approaches; excel_row=1630; RecordID=ERPathway2016_484; DatasetName=ERPathway2016; DTXSID=DTXSID4020870; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.00113; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020870
ToxValDB_ECHA_IUCLID 26 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LOAEL =42.3 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9d8e4b0a7c65d1b303f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13380/7/8?documentUUID=846fac96-b5aa-4680-b975-30a876fd729c; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15819777_15820299:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7b01b2a4ea506a56e3485bc4b36744ce
ToxValDB_ECHA_IUCLID LOAEL =54.2 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9d8e4b0a7c65d1b303f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13380/7/8?documentUUID=846fac96-b5aa-4680-b975-30a876fd729c; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15819778_15820298:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8c1986586d060c71de0d2dccec35a24b
ToxValDB_ECHA_IUCLID LOAEL =6.6 mg/kg bw/day Dog oral chronic; 142 days chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacf9e4b0a7c65d1c1ce2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13380/7/6/2?documentUUID=846fac96-b5aa-4680-b975-30a876fd729c; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15831274_15849068:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_23b5673ecdf0b0ab9386384e87436249
ToxValDB_ECHA_IUCLID LOAEL =50 mg/kg bw/day Rat oral subchronic; 52 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacf9e4b0a7c65d1c1cf2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13380/7/6/2?documentUUID=846fac96-b5aa-4680-b975-30a876fd729c; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837505_15847296:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fe0c699081d78304c072feb6182d4077
ToxValDB_ECHA_IUCLID LOAEL =200 mg/kg bw/day Rat oral subchronic; 48 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacf9e4b0a7c65d1c1cf2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13380/7/6/2?documentUUID=846fac96-b5aa-4680-b975-30a876fd729c; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837506_15847313:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7554569bef92fad88e4a3a5b494f744c
ToxValDB_ECHA_IUCLID LOAEL =618 mg/kg bw/day Rat oral subchronic; 12 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacf9e4b0a7c65d1c1cf8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13380/7/6/2?documentUUID=846fac96-b5aa-4680-b975-30a876fd729c; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15839223_15850478:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f0ed8ea13a459c5e8c2fc7198ec1fe62
ToxValDB_ECHA_IUCLID LOAEL =75.65 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacf9e4b0a7c65d1c1cfc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13380/7/6/2?documentUUID=846fac96-b5aa-4680-b975-30a876fd729c; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15844499_15848871:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_92fc9d3915fedaf486382518199d17cd
ToxValDB_ECHA_IUCLID LOAEL =113.16 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacf9e4b0a7c65d1c1cfc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13380/7/6/2?documentUUID=846fac96-b5aa-4680-b975-30a876fd729c; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15844500_15848442:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2f14090d724dc94d67284be1a772bbfd
ToxValDB_ECHA_IUCLID LOAEL =88 mg/kg bw/day Rat oral subchronic; 12 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacf9e4b0a7c65d1c1cf8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13380/7/6/2?documentUUID=846fac96-b5aa-4680-b975-30a876fd729c; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID:15850477:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_d3b9654dee770c09f821b43acce324c7
ToxValDB_ECHA_IUCLID LOAEL =345.4 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa71e4b0a7c65d1b5d62; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13380/7/9/2?documentUUID=846fac96-b5aa-4680-b975-30a876fd729c; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15856584_15856649_15856826_15856849_15860870_15860964:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9685d4315155aff9c21558e55a6b0f92
ToxValDB_ECHA_IUCLID LOAEL <=447 mg/kg bw/day Mouse oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa71e4b0a7c65d1b5d59; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13380/7/9/2?documentUUID=846fac96-b5aa-4680-b975-30a876fd729c; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15860350_15861138:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fecbad74260b0b593461d9c9e6d98880
ToxValDB_ECHA_IUCLID LOAEL <=60 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa71e4b0a7c65d1b5d65; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13380/7/9/2?documentUUID=846fac96-b5aa-4680-b975-30a876fd729c; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15860359_15861545:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6eed1c3c5d8c4a4a931269f8714c6edf
ToxValDB_ECHA_IUCLID LOAEL >=371 mg/kg bw/day Mouse oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa71e4b0a7c65d1b5d59; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13380/7/9/2?documentUUID=846fac96-b5aa-4680-b975-30a876fd729c; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15860350_15861138:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3fe9bf17a0d34afc2647b005f2f39e21
ToxValDB_ECHA_IUCLID LOAEL >=40 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa71e4b0a7c65d1b5d65; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13380/7/9/2?documentUUID=846fac96-b5aa-4680-b975-30a876fd729c; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15860359_15861545:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_47102ea95f61d2e00ed2fc311117b2ab
ToxValDB_ECHA_IUCLID NOAEL =15.1 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9d8e4b0a7c65d1b303f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13380/7/8?documentUUID=846fac96-b5aa-4680-b975-30a876fd729c; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15819778_15820298:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_cfadaf04c68423d3650087431eb668d5
ToxValDB_ECHA_IUCLID NOAEL =12.7 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9d8e4b0a7c65d1b303f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13380/7/8?documentUUID=846fac96-b5aa-4680-b975-30a876fd729c; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15819777_15820299:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4eea6ba9d5e6cad6b48acc4b66c5d849
ToxValDB_ECHA_IUCLID NOAEL =50 mg/kg bw/day Rat oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabc5e4b0a7c65d1bbb26; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13380/7/9/3?documentUUID=846fac96-b5aa-4680-b975-30a876fd729c; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID:15824093:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b74bc68abbf9167b3803f94aa02f49a2
ToxValDB_ECHA_IUCLID NOAEL =12.5 mg/kg bw/day Rat oral subchronic; 52 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacf9e4b0a7c65d1c1cf2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13380/7/6/2?documentUUID=846fac96-b5aa-4680-b975-30a876fd729c; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837505_15847296:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_51c15a1d5bfed71f303e5015247bb0f5
ToxValDB_ECHA_IUCLID NOAEL =31.3 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacf9e4b0a7c65d1c1cfc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13380/7/6/2?documentUUID=846fac96-b5aa-4680-b975-30a876fd729c; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15844500_15848442:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_d01e037fd50a3d94c9fd6f4275897ad8
ToxValDB_ECHA_IUCLID NOAEL =24.91 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacf9e4b0a7c65d1c1cfc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13380/7/6/2?documentUUID=846fac96-b5aa-4680-b975-30a876fd729c; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15844499_15848871:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_d6af67eb53959b09c636e1d115f70cdd
ToxValDB_ECHA_IUCLID NOAEL =4 mg/kg bw/day Dog oral chronic; 142 days chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacf9e4b0a7c65d1c1ce2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13380/7/6/2?documentUUID=846fac96-b5aa-4680-b975-30a876fd729c; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15831274_15849068:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_67e26629f1d68297c7f00d21d4ef3a1c
ToxValDB_ECHA_IUCLID NOAEL =104 mg/kg bw/day Rat oral subchronic; 12 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacf9e4b0a7c65d1c1cf8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13380/7/6/2?documentUUID=846fac96-b5aa-4680-b975-30a876fd729c; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15839223_15850478:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8882b1cc79731d59866363a1bcd5eef5
ToxValDB_ECHA_IUCLID NOAEL =54.2 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa71e4b0a7c65d1b5d5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13380/7/9/2?documentUUID=846fac96-b5aa-4680-b975-30a876fd729c; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15856584_15856649_15856826_15856849_15860870_15860964:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_150651c4ea2db596d13f8e7264f0bfe5
ToxValDB_ECHA_IUCLID NOAEL =104 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab0ce4b0a7c65d1b8950; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5565/7/9/2?documentUUID=17f312a7-4cfd-479a-b588-5259b31810fe; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15856584_15856649_15856826_15856849_15860870_15860964:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a5de158746f10683347e2eabb237ef0f
ToxValDB_ECHA_IUCLID NOAEL =113.16 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa71e4b0a7c65d1b5d62; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13380/7/9/2?documentUUID=846fac96-b5aa-4680-b975-30a876fd729c; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15856584_15856649_15856826_15856849_15860870_15860964:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_82378e002b83c70614e05d8eab9cdcc2
ToxValDB_ECHA_IUCLID NOAEL =800 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab0ce4b0a7c65d1b8948; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5565/7/9/2?documentUUID=17f312a7-4cfd-479a-b588-5259b31810fe; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15861818:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_cd86f736e71d4e8feddcc89a16237f1c
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =1.25 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15633371:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_949a37bf90c2171dc7c2b70a189cab86
ToxValDB_HESS 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_HESS NOEL <0.12 % Rat oral - subchronic STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0df2e4b0a676289de970; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=Deaths: Survival rate.6 (45% % ).0 (20% % )|Body Weight Changes: decrease |Food Consumption: decrease |Hematology: Hgb decrease RBC decrease|Blood Chemistry: Cho increase Glu decrease, PL increase, F-Cho increase, gamma-GTP increase , Che decrease|Absolute Organ Weight: Testis decrease , Ovary decrease , Liver increase|Relative Organ Weight: Liver increase , Testis decrease , Ovary decrease|Histopathology: Testis-tubules atrophy, Giant cell, Spermatogenesis arrest, Interstitial edema Epididymis-Hypospermia Thymus-Atrophy Epididymis-Atrophy Seminal vesicle-Atrophy , Prostate gland-Atrophy Bone marrow-Hypoplasia Ovary-Atrophy Uterus-Atrophy ); TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|food and/or water consumption|hematology|mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=HESS:15638191:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6fc08363f3fb01341414cbe73ab48442
ToxValDB_HESS NOEL =1.92 mg/kg bw/day Rat oral - subchronic STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0debe4b0a676289de6b0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=HESS:15638192:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_350a4699242ca9625368c2930089ee3a
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier KVM0X4X57B UNII - - - chemical {"approval_status":null,"molecular_formula":"C23H32O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"KVM0X4X57B"}
openFDA substances FDA UNII substance identifier KVM0X4X57B UNII - - - chemical {"approval_status":null,"molecular_formula":"C23H32O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"KVM0X4X57B"}
openFDA substances FDA UNII substance identifier KVM0X4X57B UNII - - - chemical {"approval_status":null,"molecular_formula":"C23H32O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"KVM0X4X57B"}
openFDA substances FDA UNII substance identifier KVM0X4X57B UNII - - - chemical {"approval_status":null,"molecular_formula":"C23H32O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"KVM0X4X57B"}