NOAEL Studies Cosmetic Ingredient

Methylimidazoliumpropyl p-Phenylenediamine HCl NOAEL Studies

INCI: METHYLIMIDAZOLIUMPROPYL P-PHENYLENEDIAMINE HCL (DESIGNATION A166)

CAS: 220158-86-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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SCCS Opinion 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.0183 mg/kg rat oral developmental developmental toxicity p.36
SCCS Opinion NOAEL =100 mg/kg/day - - developmental developmental toxicity p.29
SCCS Opinion NOAEL =100 mg/kg bw/d rat - developmental developmental toxicity p.30
SCCS Opinion NOAEL =200 mg/kg/day rat oral 28- day NOAEL study p.14
SCCS Opinion NOAEL =300 mg/kg bw/d rat oral 90-day reproductive toxicity p.28
SCCS Opinion NOAEL =1000 mg/kg bw/d rat oral 90-day reproductive toxicity p.28
SCCS Opinion NOAEL =1000 mg/kg rat - developmental reproductive toxicity p.38
Regulatory source 10 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 200 mg/kg/day rat oral 28- day - p.14
Regulatory source developmental toxicity =0.0183 mg/kg rat oral developmental developmental toxicity p.36
Regulatory source developmental toxicity 100 mg/kg/day - - developmental developmental toxicity p.29
Regulatory source developmental toxicity 100 mg/kg bw/d rat - developmental developmental toxicity p.30
Regulatory source developmental toxicity 200 mg/kg/day rat oral developmental developmental toxicity p.36
Regulatory source developmental toxicity 1000 mg/kg bw/d rat - developmental developmental toxicity p.30
Regulatory source repeated dose toxicity 300 mg/kg bw/d rat oral 90-day repeated dose toxicity p.37
Regulatory source reproductive toxicity 300 mg/kg bw/d rat oral 90-day reproductive toxicity p.28
Regulatory source reproductive toxicity 1000 mg/kg bw/d rat oral 90-day reproductive toxicity p.28
Regulatory source reproductive toxicity 1000 mg/kg rat - developmental reproductive toxicity p.38