Methylimidazoliumpropyl p-Phenylenediamine HCl

INCI: METHYLIMIDAZOLIUMPROPYL P-PHENYLENEDIAMINE HCL (DESIGNATION A166)

CAS Number
220158-86-1
Function
Hair Dyeing - oxidative hair dye precursor
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
EU Max Conc. 2%
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Allowed - coal tar hair dyes are exempt from certain FDA requirements under FD&C Act ยง601(a), provided they carry required caution labeling and patch-test instructions

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Strong skin sensitiser per SCCS Opinion SCCS/1609/19; the SCCS nonetheless concluded it is safe at โ‰ค2% on-head in oxidative formulations; mandatory warning statements and "not intended for dyeing eyelashes or eyebrows" labeling required in the EU. Modified p-phenylenediamine derivative bearing an imidazolium-propyl side chain; the salt form is chloride dihydrochloride; designed as a coupling/primary intermediate for oxidative color development

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Concern Level: Moderate

Frequently Asked Questions

Is Methylimidazoliumpropyl p-Phenylenediamine HCl safe in cosmetics?

Strong skin sensitiser per SCCS Opinion SCCS/1609/19; the SCCS nonetheless concluded it is safe at โ‰ค2% on-head in oxidative formulations; mandatory warning statements and "not intended for dyeing eyelashes or eyebrows" labeling required in the EU. Modified p-phenylenediamine derivative bearing an imidazolium-propyl side chain; the salt form is chloride dihydrochloride; designed as a coupling/primary intermediate for oxidative color development The EU classifies Methylimidazoliumpropyl p-Phenylenediamine HCl as "restricted". Safety rating: MODERATE.

Is Methylimidazoliumpropyl p-Phenylenediamine HCl allowed in the EU?

Methylimidazoliumpropyl p-Phenylenediamine HCl EU regulatory status: restricted. Maximum allowed concentration: 2%. This is based on EU Regulation 1223/2009 and its amendments.

What does Methylimidazoliumpropyl p-Phenylenediamine HCl do in cosmetics?

Methylimidazoliumpropyl p-Phenylenediamine HCl functions as: Hair Dyeing - oxidative hair dye precursor. It is classified as a cosmetic ingredient in our database. CAS number: 220158-86-1.

What is the Margin of Safety for Methylimidazoliumpropyl p-Phenylenediamine HCl?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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