METHYLISOTHIAZOLINONE (MIT)
INCI: METHYLISOTHIAZOLINONE
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
6 study endpoints found for METHYLISOTHIAZOLINONE (MIT). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| LOAEL | 75 ppm | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 19 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 28.6 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 30.09 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 40.6 mg/kg bw/day | oral | dog | oral | REACH |
| NOEL | 30 ppm | oral | rat | oral | REACH |
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
Sensitization Profile
Contact sensitization data for METHYLISOTHIAZOLINONE (MIT) based on clinical patch test studies and IFRA standards.
Source: NACDG 2021-22; ESSCA 2019/20
Expert Verdict
Preservative with good safety profile but restricted in US due to NDA requirements and known sensitization potential in specific applications.
Regulatory Flags
Frequently Asked Questions
Is METHYLISOTHIAZOLINONE (MIT) safe in cosmetics?
Preservative with good safety profile but restricted in US due to NDA requirements and known sensitization potential in specific applications. The EU classifies METHYLISOTHIAZOLINONE (MIT) as "permitted". Safety rating: GOOD. 6 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir.
Is METHYLISOTHIAZOLINONE (MIT) allowed in the EU?
METHYLISOTHIAZOLINONE (MIT) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does METHYLISOTHIAZOLINONE (MIT) do in cosmetics?
METHYLISOTHIAZOLINONE (MIT) functions as: Preservative (broad-spectrum biocide). It is classified as a Preservative in our database. CAS number: 2682-20-4.
What is the Margin of Safety for METHYLISOTHIAZOLINONE (MIT)?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for METHYLISOTHIAZOLINONE (MIT)?
The NOAEL (No Observed Adverse Effect Level) for METHYLISOTHIAZOLINONE (MIT) is 75 ppm based on a Subchronic study via oral route in rat. A total of 6 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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