Methylpropanediol

INCI: METHYLPROPANEDIOL

CAS Number
2163-42-0
Function
Solvent, antimicrobial/preservative booster, humectant
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Allowed - CIR Expert Panel assessed as safe; no irritation, sensitivity, or toxicity identified

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

CIR Expert Panel evaluation found no adverse effects. Not a known toxin or sensitizer. Considered safe at cosmetic use levels. Clear, colorless liquid glycol that can replace propylene glycol or butylene glycol. Enhances penetration of actives like salicylic acid. Boosts preservative efficacy, potentially reducing preservative concentrations needed. Mild hydrating properties with a smooth, dewy skin finish. Registered in China IECIC (No. 03287), JCIA (Japan, No. 557140), but not on Japan JSQI

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Concern Level: Moderate

Regulatory Flags

potential-allergen preservative eu_children_restricted ifra_fragrance

Frequently Asked Questions

Is Methylpropanediol safe in cosmetics?

CIR Expert Panel evaluation found no adverse effects. Not a known toxin or sensitizer. Considered safe at cosmetic use levels. Clear, colorless liquid glycol that can replace propylene glycol or butylene glycol. Enhances penetration of actives like salicylic acid. Boosts preservative efficacy, potentially reducing preservative concentrations needed. Mild hydrating properties with a smooth, dewy skin finish. Registered in China IECIC (No. 03287), JCIA (Japan, No. 557140), but not on Japan JSQI The EU classifies Methylpropanediol as "permitted". Safety rating: MODERATE.

Is Methylpropanediol allowed in the EU?

Methylpropanediol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Methylpropanediol do in cosmetics?

Methylpropanediol functions as: Solvent, antimicrobial/preservative booster, humectant. It is classified as a cosmetic ingredient in our database. CAS number: 2163-42-0.

What is the Margin of Safety for Methylpropanediol?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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