Methylsalicylatyl Glycyrrhetinate

INCI: METHYLSALICYLATYL GLYCYRRHETINATE

CAS Number
1417626-01-7
Function
Skin conditioning - maintains the skin in good condition
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not specifically prohibited or restricted; permitted under general cosmetic ingredient provisions. Note that methyl salicylate itself has been classified CMR category 2 and was added to EU Annex III (position 324), but this ester derivative is treated as a distinct INCI entry

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

As a derivative of both salicylate and glycyrrhetinic acid, potential concerns include salicylate sensitivity and the known anti-inflammatory/skin-thinning effects associated with glycyrrhetinic acid at high doses. Limited independent safety data available.. Combines anti-inflammatory benefits of glycyrrhetinic acid with salicylate functionality; relatively novel ingredient (CAS assigned ~2012+)

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Concern Level: Moderate

Frequently Asked Questions

Is Methylsalicylatyl Glycyrrhetinate safe in cosmetics?

As a derivative of both salicylate and glycyrrhetinic acid, potential concerns include salicylate sensitivity and the known anti-inflammatory/skin-thinning effects associated with glycyrrhetinic acid at high doses. Limited independent safety data available.. Combines anti-inflammatory benefits of glycyrrhetinic acid with salicylate functionality; relatively novel ingredient (CAS assigned ~2012+) The EU classifies Methylsalicylatyl Glycyrrhetinate as "permitted". Safety rating: MODERATE.

Is Methylsalicylatyl Glycyrrhetinate allowed in the EU?

Methylsalicylatyl Glycyrrhetinate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Methylsalicylatyl Glycyrrhetinate do in cosmetics?

Methylsalicylatyl Glycyrrhetinate functions as: Skin conditioning - maintains the skin in good condition. It is classified as a cosmetic ingredient in our database. CAS number: 1417626-01-7.

What is the Margin of Safety for Methylsalicylatyl Glycyrrhetinate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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