NOAEL Studies Fragrance

Musk Xylene NOAEL Studies

INCI: MUSK XYLENE

CAS: 81-15-2

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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IARC Monographs 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
IARC Monographs IARC carcinogenicity classification 3 IARC group - - 1995 IARC Monographs -
NTP ICE acute oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 >10000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_10616; row=2205; data_type=In Vivo; mixture=Chemical; chemical_name=2,4,6-Trinitro-1,3-dimethyl-5-tert-butylbenzene; preferred_name=Musk Xylene; dtxsid=DTXSID1021405; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021405; source_file=acute_oral.xlsx
NTP ICE cancer 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE cancer IARC group 3 unitless - - - WOE; IARC Carcinogenicity sheet=Data; excel_row=1643; Record_ID=cancer_4322; Data_Type=WOE; Formulation_Name=2,4,6-Trinitro-1,3-dimethyl-5-tert-butylbenzene; Mixture=Chemical; DTXSID=DTXSID1021405; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/83; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021405
NTP ICE skin sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=10626; Record_ID=skin_sensitization_invivo_2335; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1021405; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1970: report to RIFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90263-1; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021405
NTP ICE skin sensitization Induction dose per skin area 3240 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=10625; Record_ID=skin_sensitization_invivo_2335; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1021405; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=3240; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1970: report to RIFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90263-1; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021405
NTP ICE skin sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=10628; Record_ID=skin_sensitization_invivo_2335; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1021405; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1970: report to RIFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90263-1; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021405
SCCNFP Opinion 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCNFP Opinion NOAEL =10 mg/kg/d - - - reproductive toxicity p.9
Regulatory source 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - =10 mg/kg/d mouse - - - p.12
Regulatory source carcinogenicity 10 mg/kg/d mouse - - carcinogenicity p.15
Regulatory source reproductive toxicity 10 mg/kg/d - - - reproductive toxicity p.9
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 1ZAO16GU5K UNII - - - chemical -