NOAEL Studies Cosmetic Ingredient

N,N'-BIS(2-HYDROXYETHYL)-2-NITRO-P-PHENYLENEDIAMINE NOAEL Studies

CAS: 84041-77-0

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 80 mg/kg bw/day rat oral 90 day Subchronic SCCS; Rossiello, E. and Andreini, I. (2005) B 034 – 13 week oral toxicity study in rats followed by a 4 week recovery period
SCCNFP Opinion 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCNFP Opinion NOAEL =5 mg/kg bw/day - dermal Sub-chronic repeated dose toxicity p.6
SCCNFP Opinion NOAEL =50 mg/kg bw/day - dermal Sub-chronic repeated dose toxicity p.6
SCCNFP Opinion NOAEL =100 mg/kg bw/day rat dermal - dermal absorption p.9
SCCNFP Opinion NOAEL =1000 mg/kg bw/day rat dermal - dermal absorption p.9
SCCS Opinion 11 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.017 mg/kg bw/d rat oral 90-day dermal absorption p.36
SCCS Opinion NOAEL =0.029 mg/kg bw/d rat oral 90-day dermal absorption p.36
SCCS Opinion NOAEL =5 mg/kg bw/day rat - 4 weeks NOAEL study p.15
SCCS Opinion NOAEL =50 mg/kg bw/day rat - 4 weeks NOAEL study p.15
SCCS Opinion NOAEL =100 mg/kg bw/day rat oral Prenatal developmental toxicity p.32
SCCS Opinion NOAEL =120 mg/kg bw/d rat oral 90-day dermal absorption p.36
SCCS Opinion NOAEL =240 mg/kg/day - - Chronic genotoxicity p.16
SCCS Opinion NOAEL =240 mg/kg bw/d rat oral 90-day dermal absorption p.36
SCCS Opinion NOAEL =720 mg/kg bw/day mouse - 90 day irritation p.35
SCCS Opinion NOAEL =1000 mg/kg rat oral Prenatal developmental toxicity p.32
SCCS Opinion NOAEL =1200 mg/kg/day human - - NOAEL study p.27
Regulatory source 31 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source dermal absorption 100 mg/kg bw/day rat dermal - dermal absorption p.9
Regulatory source dermal absorption 1000 mg/kg bw/day rat dermal - dermal absorption p.9
Regulatory source repeated dose toxicity 5 mg/kg bw/day - dermal Sub-chronic repeated dose toxicity p.6
Regulatory source repeated dose toxicity 5 mg/kg bw/day rabbit oral subchronic repeated dose toxicity p.18
Regulatory source repeated dose toxicity 50 mg/kg bw/day - dermal Sub-chronic repeated dose toxicity p.6
Regulatory source repeated dose toxicity 50 mg/kg bw/day rabbit oral subchronic repeated dose toxicity p.18
Regulatory source repeated dose toxicity 100 mg/kg bw/day rabbit oral subchronic repeated dose toxicity p.18
Regulatory source repeated dose toxicity 1000 mg/kg bw/day rabbit oral subchronic repeated dose toxicity p.18
Regulatory source - 5 mg/kg bw/day rat - 4 weeks - p.15
Regulatory source - 50 mg/kg bw/day rat - 4 weeks - p.15
Regulatory source - 240 mg/kg/day - - - - p.15
Regulatory source - 240 mg/kg bw/d - - - - p.15
Regulatory source - 1200 mg/kg/day human - - - p.27
Regulatory source dermal absorption =0.017 mg/kg bw/d rat oral 90-day dermal absorption p.36
Regulatory source dermal absorption =0.029 mg/kg bw/d rat oral 90-day dermal absorption p.36
Regulatory source dermal absorption =120 mg/kg bw/d rat oral 90-day dermal absorption p.36
Regulatory source dermal absorption =240 mg/kg bw/d rat oral 90-day dermal absorption p.36
Regulatory source dermal absorption 1200 mg/kg/day rat dermal - dermal absorption p.33
Regulatory source developmental toxicity 100 mg/kg bw/day rat oral Prenatal developmental toxicity p.32
Regulatory source developmental toxicity 100 mg/kg bw/day rat oral Developmental developmental toxicity p.33
Regulatory source developmental toxicity 1000 mg/kg rat oral Prenatal developmental toxicity p.32
Regulatory source developmental toxicity 1000 mg/kg rat - Developmental developmental toxicity p.33
Regulatory source genotoxicity 240 mg/kg/day - - Chronic genotoxicity p.16
Regulatory source genotoxicity 240 mg/kg bw/d - - Chronic genotoxicity p.17
Regulatory source irritation 240 mg/kg/day - - 90 day irritation p.28
Regulatory source irritation 240 mg/kg bw/day - - 90 day irritation p.35
Regulatory source irritation 240 mg/kg bw/day - - 90-day irritation p.37
Regulatory source irritation 720 mg/kg bw/day mouse - 90 day irritation p.35
Regulatory source irritation 720 mg/kg bw/d mouse - 90-day irritation p.37
Regulatory source irritation 1200 mg/kg/day mouse - 90 day irritation p.28
Regulatory source irritation 1200 mg/kg bw/d mouse - 90-day irritation p.37
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 3X0E669O5S UNII - - - chemical -