N-Nicotinoyl Dopamine

INCI: N-NICOTINOYL DOPAMINE

CAS Number
Not widely assigned (research-stage compound)
Function
Skin conditioning, antioxidant and melanogenesis inhibitor (inhibits melanosome transport)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status restricted
US Notes Not specifically restricted; no FDA monograph

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Novel research-stage ingredient with catechol functional group capable of auto-oxidation to ortho-quinone, a known hapten-forming pathway. Patent literature cites use range 0.005โ€“20% w/w, but no SCCS opinion or CIR review available. Full Annex I CPSR dossier required before market entry.

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Concern Level: Moderate

Frequently Asked Questions

Is N-Nicotinoyl Dopamine safe in cosmetics?

Novel research-stage ingredient with catechol functional group capable of auto-oxidation to ortho-quinone, a known hapten-forming pathway. Patent literature cites use range 0.005โ€“20% w/w, but no SCCS opinion or CIR review available. Full Annex I CPSR dossier required before market entry. The EU classifies N-Nicotinoyl Dopamine as "permitted". Safety rating: MODERATE.

Is N-Nicotinoyl Dopamine allowed in the EU?

N-Nicotinoyl Dopamine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does N-Nicotinoyl Dopamine do in cosmetics?

N-Nicotinoyl Dopamine functions as: Skin conditioning, antioxidant and melanogenesis inhibitor (inhibits melanosome transport). It is classified as a cosmetic ingredient in our database. CAS number: Not widely assigned (research-stage compound).

What is the Margin of Safety for N-Nicotinoyl Dopamine?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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