NOAEL Studies
Cosmetic Ingredient
O-PHENYLPHENOL NOAEL Studies
CAS: 90-43-7
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
California Proposition 65 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| California Proposition 65 | California Proposition 65 listing | ABcancer | listing type | - | - | 2000-08-04 | California Proposition 65 listing | - |
EFSA 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA | NOAEL | =39 | mg/kg bw/day | Rat | oral: unspecified | 730 days | chronic/long term toxicity | EFSA - 2009 - OutputID 1173 - histopathology neoplastic - systemic - Peer review of the pesticide risk assessment of the active substance 2-phenylphenol - doi:10.2903/j.efsa.2009.217r |
| EFSA | NOAEL | =100 | mg/kg bw/day | Rabbit | - | - | reproduction toxicity | EFSA - 2009 - OutputID 1173 - body weight - systemic - Peer review of the pesticide risk assessment of the active substance 2-phenylphenol - doi:10.2903/j.efsa.2009.217r |
| EFSA | NOAEL | =500 | mg/kg bw/day | Rat | - | - | reproduction toxicity | EFSA - 2009 - OutputID 1173 - reproductive - Peer review of the pesticide risk assessment of the active substance 2-phenylphenol - doi:10.2903/j.efsa.2009.217r |
| EFSA | ADI | =0.4 | mg/kg bw/day | Consumers | - | - | ADI | EFSA - 2009 - OutputID 1173 - Consumers - Peer review of the pesticide risk assessment of the active substance 2-phenylphenol - doi:10.2903/j.efsa.2009.217r |
| EFSA | NOAEL | =39 | mg/kg bw/day | Rat | oral | chronic; 2 years | chronic | LONG_REF=EFSA (2009). Peer review of the pesticide risk assessment of the active substance 2-phenylphenol. doi:10.2903/j.efsa.2009.217r.; TITLE=Peer review of the pesticide risk assessment of the active substance 2-phenylphenol; AUTHOR=EFSA; DOI=doi:10.2903/j.efsa.2009.217r; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2009; ORIGINAL_YEAR=2009; TOXICOLOGICAL_EFFECT=histopathology: neoplastic; STUDY_GROUP=EFSA:15617597:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e9a27c53863e80df78c261e5efb07fef |
| EFSA | NOAEL | =100 | mg/kg bw/day | Rabbit | oral | - | reproduction developmental | LONG_REF=EFSA (2009). Peer review of the pesticide risk assessment of the active substance 2-phenylphenol. doi:10.2903/j.efsa.2009.217r.; TITLE=Peer review of the pesticide risk assessment of the active substance 2-phenylphenol; AUTHOR=EFSA; DOI=doi:10.2903/j.efsa.2009.217r; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2009; ORIGINAL_YEAR=2009; TOXICOLOGICAL_EFFECT=body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=EFSA:15617594:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4e86175022c56810337452a86874ecb6 |
| EFSA | NOAEL | =500 | mg/kg bw/day | Rat | oral | - | reproduction developmental | LONG_REF=EFSA (2009). Peer review of the pesticide risk assessment of the active substance 2-phenylphenol. doi:10.2903/j.efsa.2009.217r.; TITLE=Peer review of the pesticide risk assessment of the active substance 2-phenylphenol; AUTHOR=EFSA; DOI=doi:10.2903/j.efsa.2009.217r; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=EFSA:15617593:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ae294a2294bffc4709b2a1fb4d0f2ee3 |
IARC Monographs 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| IARC Monographs | IARC carcinogenicity classification | 3 | IARC group | - | - | 1998 | IARC Monographs | - |
WHO/JECFA 17 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| WHO/JECFA | ADI | range:0-0.020.02 | mg/kg bw/day | - | - | - | Health guidance value | document_id=jmpr_jmpmono_v85pr14; title=729. Phenylphenol, 2- and its sodium salt (Pesticide residues in food: 1985 evaluations Part II Toxicology); path=mirror/documents/jmpr/jmpmono/v85pr14.htm; row_hash=4dac8100e487cd7b; raw_unit=mg/kg b.w.; context=ESTIMATE OF TEMPORARY ACCEPTABLE DAILY INTAKE FOR MAN 0-0.02 mg/kg b.w. |
| WHO/JECFA | ADI | range:0-0.40.4 | mg/kg bw/day | Rat | - | 2-year | Health guidance value | document_id=jmpr_jmpmono_v99pr08; title=Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v99pr08.htm; row_hash=e8fd575f6e716261; raw_unit=mg/kg bw; context=The Meeting established an ADI of 0-0.4 mg/kg bw for 2-phenylphenol, on the basis of the NOAEL of 39 mg/kg per day in the 2-year study of toxicity (based on decreased body-weight gain and hyperplasia of the urinary bladder) and carcinogenicity of the urinary bladder in male rats and a safety factor of 100. |
| WHO/JECFA | NOAEL | =39 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jmpr_jmpmono_v99pr08; title=Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v99pr08.htm; row_hash=19219f39bd545aa0; raw_unit=mg/kg bw per day; context=The NOAEL for toxicity was 800 ppm, equal to 39 mg/kg bw per day, on the basis of reduced body-weight gain and hyperplasia in the urinary bladder at all doses. |
| WHO/JECFA | NOAEL | =92 | mg/kg bw/day | Mouse | - | - | Developmental toxicity | document_id=jmpr_jmpmono_v99pr08; title=Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v99pr08.htm; row_hash=027f3eeecd940b7c; raw_unit=mg/kg bw per day; context=The NOAEL for systemic and developmental toxicity was 92 mg/kg bw per day, on the basis of decreased body weight and morphological lesions in the kidneys, urinary bladder, and ureter and a decrease in pup body weight (Eigenberg, 1995). (ii) Developmental toxicity 2-Phenylphenol and sodium 2-phenylphenol Mice Groups of 20-21 pregnan |
| WHO/JECFA | NOAEL | =95 | mg/kg bw/day | - | - | - | Carcinogenicity | document_id=jmpr_jmpmono_v99pr08; title=Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v99pr08.htm; row_hash=a309c1323e0048a8; raw_unit=mg/kg bw per day; context=The NOAEL was 2500 ppm, equal to 95 mg/kg bw per day, on the basis of urinary bladder tumours at all doses (Hiraga, 1983b; |
| WHO/JECFA | NOAEL | =100 | mg/kg bw/day | - | - | - | Developmental toxicity | document_id=jmpr_jmpmono_v99pr08; title=Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v99pr08.htm; row_hash=ed04f24cabe2434b; raw_unit=mg/kg bw per day; context=The NOAEL was 100 mg/kg bw per day for fetotoxicity and 400 mg/kg bw per day, the highest dose tested, for developmental toxicity (Ogata et al., 1978). |
| WHO/JECFA | NOAEL | =150 | mg/kg bw/day | - | - | - | Developmental toxicity | document_id=jmpr_jmpmono_v99pr08; title=Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v99pr08.htm; row_hash=49f26599ffd868dc; raw_unit=mg/kg bw per day; context=The NOAEL was 150 mg/kg bw per day for maternal toxicity, 300 mg/kg bw per day for fetotoxicity, and 600 mg/kg bw per day, the highest dose tested, for developmental toxicity (Kaneda et al., 1978). |
| WHO/JECFA | NOAEL | =180 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jmpr_jmpmono_v99pr08; title=Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v99pr08.htm; row_hash=e08e4ec9b84fda5a; raw_unit=mg/kg bw per day; context=The NOAEL was 2500 ppm, equal to 180 mg/kg bw per day, on the basis of reduced body-weight gain at 5000 ppm (Iguchi et al., 1979; |
| WHO/JECFA | NOAEL | =250 | mg/kg bw/day | - | - | - | Carcinogenicity | document_id=jmpr_jmpmono_v99pr08; title=Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v99pr08.htm; row_hash=b4c6208030a21267; raw_unit=mg/kg bw per day; context=The NOAEL for carcinogenicity was 250 mg/kg bw per day on the basis of an increased incidence of hepatocellular adenomas at 500 mg/kg bw per day (Quast & McGuirk, 1995). |
| WHO/JECFA | NOAEL | =270 | mg/kg bw/day | - | - | - | Carcinogenicity | document_id=jmpr_jmpmono_v99pr08; title=Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v99pr08.htm; row_hash=3c0409dcfb8c1249; raw_unit=mg/kg bw per day; context=The NOAEL was 2500 ppm, equivalent to 270 mg/kg bw per day, on the basis of the increased incidence of urinary bladder tumours (Hiraga & Fujii, 1981). |
| WHO/JECFA | NOAEL | =300 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jmpr_jmpmono_v99pr08; title=Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v99pr08.htm; row_hash=d8cea569b34d850f; raw_unit=mg/kg bw per day; context=The NOAEL was 300 mg/kg bw per day (Cosse et al., 1990). |
| WHO/JECFA | NOAEL | =460 | mg/kg bw/day | - | - | - | Reproductive toxicity | document_id=jmpr_jmpmono_v99pr08; title=Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v99pr08.htm; row_hash=c900008bf6056cc8; raw_unit=mg/kg bw per day; context=The NOAEL for reproductive toxicity was 460 mg/kg bw per day and that for carcinogenicity was 36 mg/kg bw per day (Eigenberg, 1990). |
| WHO/JECFA | NOAEL | =550 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jmpr_jmpmono_v99pr08; title=Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v99pr08.htm; row_hash=7d51123515cc5aba; raw_unit=mg/kg bw per day; context=The NOAEL was 5000 ppm, equivalent to 550 mg/kg bw per day, on the basis of reduced body-weight gain and increased relative liver weight at 10 000 ppm (Shibata et al., 1985). |
| WHO/JECFA | NOAEL | =760 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jmpr_jmpmono_v99pr08; title=Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v99pr08.htm; row_hash=23a7d3ef1d6196c7; raw_unit=mg/kg bw per day; context=The NOAEL was 6300 ppm, equal to 760 mg/kg bw per day, on the basis of reduced body weight and body-weight gain at 13 000 ppm (Iguchi et al., 1984). |
| WHO/JECFA | NOAEL | =2100 | mg/kg bw/day | - | - | - | Developmental toxicity | document_id=jmpr_jmpmono_v99pr08; title=Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v99pr08.htm; row_hash=14b62229d1247e7b; raw_unit=mg/kg bw per day; context=The NOAEL for developmental toxicity was 2100 mg/kg bw per day, the highest dose tested. |
| WHO/JECFA | NOAEL | =3000 | mg/kg bw/day | - | - | - | Carcinogenicity | document_id=jmpr_jmpmono_v99pr08; title=Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v99pr08.htm; row_hash=5d2c3b0f19b5d68b; raw_unit=mg/kg bw per day; context=The NOAEL for carcinogenicity was 20 000 ppm, equal to 3000 mg/kg bw per day, the highest dose tested (Ito, 1983a; |
| WHO/JECFA | ADI | <=0.4 | mg/kg | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c95295e4b02565fc7d2c82; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.who.int/teams/environment-climate-change-and-health/water-sanitation-and-health/chemical-hazards-in-drinking-water; YEAR=2003; ORIGINAL_YEAR=2003; STUDY_GROUP=WHO DWG:15954936:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_206c98a27f71ccf9e92a4534b7add5b2 |
NTP ICE acute dermal 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute dermal | EPA classification | 3 | unitless | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=673; Record_ID=acute_dermal_527; Data_Type=In Vivo; Formulation_ID=MIX520; Formulation_Name=Veriguard OD; Percent_Active_Ingredient=15.0; Mixture=Mixture; DTXSID=DTXSID2021151; Assay=Rat Acute Dermal Toxicity; Endpoint=EPA classification; Response=3.0; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021151 |
| NTP ICE acute dermal | EPA classification | 4 | unitless | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=668; Record_ID=acute_dermal_96; Data_Type=In Vivo; Formulation_ID=MIX95; Formulation_Name=Chemsico Aerosol LEG; Percent_Active_Ingredient=0.1; Mixture=Mixture; DTXSID=DTXSID2021151; Assay=Rat Acute Dermal Toxicity; Endpoint=EPA classification; Response=4.0; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021151 |
| NTP ICE acute dermal | GHS classification | 5 | unitless | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=664; Record_ID=acute_dermal_312; Data_Type=In Vivo; Formulation_ID=MIX305; Formulation_Name=Mediclean Carpet Sanitizer; Percent_Active_Ingredient=4.02; Mixture=Mixture; DTXSID=DTXSID2021151; Assay=Rat Acute Dermal Toxicity; Endpoint=GHS classification; Response=5.0; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021151 |
| NTP ICE acute dermal | LD50 | >2000 | mg/kg | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=667; Record_ID=acute_dermal_527; Data_Type=In Vivo; Formulation_ID=MIX520; Formulation_Name=Veriguard OD; Percent_Active_Ingredient=15.0; Mixture=Mixture; DTXSID=DTXSID2021151; Assay=Rat Acute Dermal Toxicity; Endpoint=LD50; Response_Modifier=>; Response=2000.0; Response_Unit=mg/kg; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021151 |
| NTP ICE acute dermal | LD50 | >5000 | mg/kg | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=669; Record_ID=acute_dermal_96; Data_Type=In Vivo; Formulation_ID=MIX95; Formulation_Name=Chemsico Aerosol LEG; Percent_Active_Ingredient=0.1; Mixture=Mixture; DTXSID=DTXSID2021151; Assay=Rat Acute Dermal Toxicity; Endpoint=LD50; Response_Modifier=>; Response=5000.0; Response_Unit=mg/kg; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021151 |
NTP ICE acute inhalation 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute inhalation | EPA Classification | 3 | unitless | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1360; Record_ID=acute_inhalation_298; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX378; Formulation_Name=Raid Ant & Roach Killer with Germ Kill CIK; Percent_Active_Ingredient=0.1; Mixture=Mixture; DTXSID=DTXSID2021151; Assay=Rat Acute Inhalation Toxicity; Endpoint=EPA Classification; Response=3; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021151 |
| NTP ICE acute inhalation | EPA Classification | 4 | unitless | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1349; Record_ID=acute_inhalation_440; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX520; Formulation_Name=Veriguard OD; Percent_Active_Ingredient=15.0; Mixture=Mixture; DTXSID=DTXSID2021151; Assay=Rat Acute Inhalation Toxicity; Endpoint=EPA Classification; Response=4; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021151 |
| NTP ICE acute inhalation | LC50 | >0.036 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1348; Record_ID=acute_inhalation_1083; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID2021151; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=0.036; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/2168/7/3/3/?documentUUID=2c055818-6ebe-445b-a148-666d8d7f478a; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021151 |
| NTP ICE acute inhalation | LC50 | >0.949 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1357; Record_ID=acute_inhalation_1081; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID2021151; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=0.949; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/2168/7/3/3/?documentUUID=1450d78a-7992-4513-94af-13e0de39c659; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021151 |
| NTP ICE acute inhalation | LC50 | 2.09 | mg/L | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1354; Record_ID=acute_inhalation_300; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX378; Formulation_Name=Raid Ant & Roach Killer with Germ Kill CIK; Percent_Active_Ingredient=0.1; Mixture=Mixture; DTXSID=DTXSID2021151; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=2.09; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021151 |
| NTP ICE acute inhalation | LC50 | >2.1 | mg/L | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1355; Record_ID=acute_inhalation_440; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX520; Formulation_Name=Veriguard OD; Percent_Active_Ingredient=15.0; Mixture=Mixture; DTXSID=DTXSID2021151; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=2.1; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021151 |
| NTP ICE acute inhalation | LC50 | 2.16 | mg/L | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1358; Record_ID=acute_inhalation_491; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX95; Formulation_Name=Chemsico Aerosol LEG; Percent_Active_Ingredient=0.1; Mixture=Mixture; DTXSID=DTXSID2021151; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=2.16; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021151 |
NTP ICE acute oral 13 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | EPA classification | =3 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12720; row=3857; data_type=In Vivo; mixture=Mixture; formulation_id=MIX305; formulation_name=Mediclean Carpet Sanitizer; chemical_name=2-Phenylphenol; preferred_name=2-Phenylphenol; percent_active_ingredient=4.02; dtxsid=DTXSID2021151; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021151; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021151; source_file=acute_oral.xlsx |
| NTP ICE acute oral | EPA classification | =4 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12345; row=3866; data_type=In Vivo; mixture=Mixture; formulation_id=MIX95; formulation_name=Chemsico Aerosol LEG; chemical_name=2-Phenylphenol; preferred_name=2-Phenylphenol; percent_active_ingredient=0.1; dtxsid=DTXSID2021151; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021151; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021151; source_file=acute_oral.xlsx |
| NTP ICE acute oral | EPA classification | =4 | Unitless | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12878; row=3872; data_type=In Vivo; mixture=Mixture; formulation_id=MIX378; formulation_name=Raid Ant & Roach Killer with Germ Kill CIK; chemical_name=2-Phenylphenol; preferred_name=2-Phenylphenol; percent_active_ingredient=0.1; dtxsid=DTXSID2021151; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021151; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021151; source_file=acute_oral.xlsx |
| NTP ICE acute oral | GHS classification | =4 | Unitless | Rat (Male/Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12820; row=3884; data_type=In Vivo; mixture=Mixture; formulation_id=MIX650; formulation_name=Orthophenylphenol/Sodium Orthophenylphenate; chemical_name=2-Phenylphenol; preferred_name=2-Phenylphenol; percent_active_ingredient=99.9; dtxsid=DTXSID2021151; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021151; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021151; source_file=acute_oral.xlsx |
| NTP ICE acute oral | GHS classification | =4 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12720; row=3892; data_type=In Vivo; mixture=Mixture; formulation_id=MIX305; formulation_name=Mediclean Carpet Sanitizer; chemical_name=2-Phenylphenol; preferred_name=2-Phenylphenol; percent_active_ingredient=4.02; dtxsid=DTXSID2021151; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021151; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021151; source_file=acute_oral.xlsx |
| NTP ICE acute oral | GHS classification | =5 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12345; row=3871; data_type=In Vivo; mixture=Mixture; formulation_id=MIX95; formulation_name=Chemsico Aerosol LEG; chemical_name=2-Phenylphenol; preferred_name=2-Phenylphenol; percent_active_ingredient=0.1; dtxsid=DTXSID2021151; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021151; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021151; source_file=acute_oral.xlsx |
| NTP ICE acute oral | GHS classification | =5 | Unitless | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12878; row=3876; data_type=In Vivo; mixture=Mixture; formulation_id=MIX378; formulation_name=Raid Ant & Roach Killer with Germ Kill CIK; chemical_name=2-Phenylphenol; preferred_name=2-Phenylphenol; percent_active_ingredient=0.1; dtxsid=DTXSID2021151; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021151; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021151; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =591 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12825; row=3861; data_type=In Vivo; mixture=Mixture; formulation_id=MIX650; formulation_name=Orthophenylphenol/Sodium Orthophenylphenate; chemical_name=2-Phenylphenol; preferred_name=2-Phenylphenol; percent_active_ingredient=99.9; dtxsid=DTXSID2021151; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021151; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021151; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =846 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12824; row=3869; data_type=In Vivo; mixture=Mixture; formulation_id=MIX650; formulation_name=Orthophenylphenol/Sodium Orthophenylphenate; chemical_name=2-Phenylphenol; preferred_name=2-Phenylphenol; percent_active_ingredient=99.9; dtxsid=DTXSID2021151; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021151; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021151; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | >2000 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_13118; row=3867; data_type=In Vivo; mixture=Mixture; formulation_id=MIX520; formulation_name=Veriguard OD; chemical_name=2-Phenylphenol; preferred_name=2-Phenylphenol; percent_active_ingredient=15.0; dtxsid=DTXSID2021151; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021151; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021151; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =2733 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12822; row=3862; data_type=In Vivo; mixture=Mixture; formulation_id=MIX650; formulation_name=Orthophenylphenol/Sodium Orthophenylphenate; chemical_name=2-Phenylphenol; preferred_name=2-Phenylphenol; percent_active_ingredient=99.9; dtxsid=DTXSID2021151; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021151; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021151; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | >5000 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12882; row=3858; data_type=In Vivo; mixture=Mixture; formulation_id=MIX378; formulation_name=Raid Ant & Roach Killer with Germ Kill CIK; chemical_name=2-Phenylphenol; preferred_name=2-Phenylphenol; percent_active_ingredient=0.1; dtxsid=DTXSID2021151; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021151; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021151; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | >5000 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12718; row=3868; data_type=In Vivo; mixture=Mixture; formulation_id=MIX305; formulation_name=Mediclean Carpet Sanitizer; chemical_name=2-Phenylphenol; preferred_name=2-Phenylphenol; percent_active_ingredient=4.02; dtxsid=DTXSID2021151; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021151; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021151; source_file=acute_oral.xlsx |
NTP ICE adme parameters 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE adme parameters | Clint | 2.077 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=820; Record_ID=adme_parameters_5; Data_Type=Measured; DTXSID=DTXSID2021151; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=2.077; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wetmore 2012; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021151 |
| NTP ICE adme parameters | Fu | 0.04105 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=819; Record_ID=adme_parameters_5; Data_Type=Measured; DTXSID=DTXSID2021151; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.04105; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wetmore 2012; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021151 |
NTP ICE cancer 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE cancer | IARC group | 3 | unitless | - | - | - | WOE; IARC Carcinogenicity | sheet=Data; excel_row=2579; Record_ID=cancer_4824; Data_Type=WOE; Formulation_Name=2-Phenylphenol; Mixture=Chemical; DTXSID=DTXSID2021151; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/91; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021151 |
NTP ICE endocrine 12 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | AC50 | 41.37403025207 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=2740; RecordID=ERPathway2016_438; DatasetName=ERPathway2016; DTXSID=DTXSID2021151; Assay=ER Pathway Model, Antagonist; Endpoint=AC50; Response=41.37403025207; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021151 |
| NTP ICE endocrine | AC50/EC50/IC50 | 3430 | nM | - | - | - | In Vitro; AR Transactivation-Antagonist | sheet=Data_invitro; excel_row=13506; Record_ID=endocrine_invitro_4165; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2021151; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=3430; Reported_Response_Unit=nM; Response=3430; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Orton et al. 2011; 21310686; 10.1289/ehp.1002895; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021151 |
| NTP ICE endocrine | AC50/EC50/IC50 | 6300 | nM | - | - | - | In Vitro; AR Transactivation-Antagonist | sheet=Data_invitro; excel_row=13239; Record_ID=endocrine_invitro_4099; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2021151; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=6300; Reported_Response_Unit=nM; Response=6300; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Krüger et al. 2008; 18294747; 10.1016/j.tox.2007.12.028; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021151 |
| NTP ICE endocrine | AC50/EC50/IC50 | 12100 | nM | - | - | - | In Vitro; AR Transactivation-Antagonist | sheet=Data_invitro; excel_row=13241; Record_ID=endocrine_invitro_4100; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2021151; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=12100; Reported_Response_Unit=nM; Response=12100; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Indiveri et al. 2014; 24972338; 10.1016/j.reprotox.2014.06.004; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021151 |
| NTP ICE endocrine | ACC | 38.34237180221 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=2741; RecordID=ERPathway2016_438; DatasetName=ERPathway2016; DTXSID=DTXSID2021151; Assay=ER Pathway Model, Antagonist; Endpoint=ACC; Response=38.34237180221; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021151 |
| NTP ICE endocrine | IC20 | 49000 | nM | - | - | - | In Vitro; AR Transactivation-Antagonist | sheet=Data_invitro; excel_row=13040; Record_ID=endocrine_invitro_4040; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2021151; Assay=AR Transactivation-Antagonist; Endpoint=IC20; Reported_Response=49000; Reported_Response_Unit=IC20 (nM); Response=49000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021151 |
| NTP ICE endocrine | LEL | 10000 | nM | - | - | - | In Vitro; AR Transactivation-Antagonist | sheet=Data_invitro; excel_row=14971; Record_ID=endocrine_invitro_4099; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2021151; Assay=AR Transactivation-Antagonist; Endpoint=LEL; Reported_Response=10000; Reported_Response_Unit=nM; Response=10000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Krüger et al. 2008; 18294747; 10.1016/j.tox.2007.12.028; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021151 |
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=2736; RecordID=ARPathway2016_1703; DatasetName=ARPathway2016; DTXSID=DTXSID2021151; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021151 |
| NTP ICE endocrine | Model Score | 0.00543 | unitless | - | - | - | ERPathway2016; ER Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=2742; RecordID=ERPathway2016_438; DatasetName=ERPathway2016; DTXSID=DTXSID2021151; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.00543; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021151 |
| NTP ICE endocrine | NOEL | 1000 | mg/kg bw/day | Rat | Oral | Treatment_Duration=10 days; Age_at_First_Dose=PND 55; Age_Ovariectomized_or_Castrated=PND 45; Time_Elapsed_Between_Surgery_and_Treatment=10 days; Time_Elapsed_Between_Last_Dose_and_Necropsy=18 to 36 hours; Number_of_Doses_Tested=7 | In Vivo; Hershberger-Agonist | sheet=Data_invivo; excel_row=1202; Record_ID=endocrine_invivo_521; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID2021151; Assay=Hershberger-Agonist; Endpoint=NOEL; Response=1000; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Sprague-Dawley; Strain=Sprague-Dawley; Sex=Male (castrated); Route=Oral; Reference_Hormone=Testosterone propionate; Reference_Hormone_Dose=0.4; Reference_Hormone_Dose_Units=mg/kg/day; Reference_Hormone_Route=Subcutaneous; Additional_Information=Browne et al. 2018 unique record identifier 448; Reference=US EPA 2013; Not available; https://www.regulations.gov/document/EPA-HQ-OPP-2013-0524-0010|Browne et al. 2018; 30205136; 10.1016/j.reprotox.2018.08.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021151 |
| NTP ICE endocrine | Relative potency | 7 | % | - | - | - | In Vitro; AR Transactivation-Antagonist | sheet=Data_invitro; excel_row=15208; Record_ID=endocrine_invitro_4100; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2021151; Assay=AR Transactivation-Antagonist; Endpoint=Relative potency; Reported_Response=7; Reported_Response_Unit=%; Response=7; Response_Unit=%; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Indiveri et al. 2014; 24972338; 10.1016/j.reprotox.2014.06.004; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021151 |
| NTP ICE endocrine | Relative potency | 59 | % | - | - | - | In Vitro; AR Transactivation-Antagonist | sheet=Data_invitro; excel_row=15209; Record_ID=endocrine_invitro_4040; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2021151; Assay=AR Transactivation-Antagonist; Endpoint=Relative potency; Reported_Response=59; Reported_Response_Unit=%; Response=59; Response_Unit=%; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021151 |
NTP ICE eye irritation 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE eye irritation | EPA Classification | 1 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=748; Record_ID=eye_irritation_1208; Data_Type=In Vivo; Formulation_ID=EyeIrritation6pack_PID1034; Formulation_Name=Veriguard OD; Percent_Active_Ingredient=15.0; Mixture=Mixture; DTXSID=DTXSID2021151; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=1; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021151 |
| NTP ICE eye irritation | EPA Classification | 3 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=744; Record_ID=eye_irritation_401; Data_Type=In Vivo; Formulation_ID=EyeIrritation6pack_PID222; Formulation_Name=Chemsico Aerosol LEG; Percent_Active_Ingredient=0.1; Mixture=Mixture; DTXSID=DTXSID2021151; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=3; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021151 |
NTP ICE skin irritation 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin irritation | EPA classification | 1 | unitless | Rabbit | Dermal | - | In Vivo; Draize Skin Irritation/Corrosion Test | sheet=Data_invivo; excel_row=526; Record_ID=skin_irritation_invivo_178; Data_Type=In Vivo; Formulation_ID=MIX650; Formulation_Name=Orthophenylphenol/Sodium Orthophenylphenate; Percent_Active_Ingredient=99.9; Mixture=Mixture; DTXSID=DTXSID2021151; Assay=Draize Skin Irritation/Corrosion Test; Endpoint=EPA classification; Response=1; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021151 |
| NTP ICE skin irritation | EPA classification | 2 | unitless | Rabbit | Dermal | - | In Vivo; Draize Skin Irritation/Corrosion Test | sheet=Data_invivo; excel_row=522; Record_ID=skin_irritation_invivo_677; Data_Type=In Vivo; Formulation_ID=MIX378; Formulation_Name=Raid Ant & Roach Killer with Germ Kill CIK; Percent_Active_Ingredient=0.1; Mixture=Mixture; DTXSID=DTXSID2021151; Assay=Draize Skin Irritation/Corrosion Test; Endpoint=EPA classification; Response=2; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021151 |
| NTP ICE skin irritation | EPA classification | 3 | unitless | Rabbit | Dermal | - | In Vivo; Draize Skin Irritation/Corrosion Test | sheet=Data_invivo; excel_row=524; Record_ID=skin_irritation_invivo_1049; Data_Type=In Vivo; Formulation_ID=MIX95; Formulation_Name=Chemsico Aerosol LEG; Percent_Active_Ingredient=0.1; Mixture=Mixture; DTXSID=DTXSID2021151; Assay=Draize Skin Irritation/Corrosion Test; Endpoint=EPA classification; Response=3; Response_Unit=Unitless; Species=Rabbit; Reported_Strain=New Zealand White; Strain=New Zealand White; Sex=Male; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021151 |
| NTP ICE skin irritation | EPA classification | 4 | unitless | Rabbit | Dermal | - | In Vivo; Draize Skin Irritation/Corrosion Test | sheet=Data_invivo; excel_row=523; Record_ID=skin_irritation_invivo_855; Data_Type=In Vivo; Formulation_ID=MIX520; Formulation_Name=Veriguard OD; Percent_Active_Ingredient=15; Mixture=Mixture; DTXSID=DTXSID2021151; Assay=Draize Skin Irritation/Corrosion Test; Endpoint=EPA classification; Response=4; Response_Unit=Unitless; Species=Rabbit; Reported_Strain=New Zealand White; Strain=New Zealand White; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021151 |
SCCS Opinion 85 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCS Opinion | NOAEL | =2 | % | rat | - | 2-year | carcinogenicity | p.94 |
| SCCS Opinion | NOAEL | =2.5 | % | rat | oral | - | NOAEL study | p.80 |
| SCCS Opinion | NOAEL | =2.5 | % | rat | oral | Sub-chronic | repeated dose toxicity | p.66 |
| SCCS Opinion | NOAEL | =4 | % | rat | oral | - | NOAEL study | p.80 |
| SCCS Opinion | NOAEL | =4 | % | mouse | oral | 13-week | NOAEL study | p.67 |
| SCCS Opinion | NOAEL | =22.4 | mg/kg bw/day | rat | oral | 104-week | developmental toxicity | p.37 |
| SCCS Opinion | NOAEL | =25 | mg/kg/d | rat | - | developmental | developmental toxicity | p.35 |
| SCCS Opinion | NOAEL | =25 | mg/kg bw/d | - | - | developmental | developmental toxicity | p.38 |
| SCCS Opinion | NOAEL | =25 | mg/kg bw/day | rat | - | developmental | developmental toxicity | p.31 |
| SCCS Opinion | NOAEL | =25 | mg/kg/d | rabbit | oral | developmental | reproductive toxicity | p.31 |
| SCCS Opinion | NOAEL | =25 | mg/kg bw/d | rabbit | oral | developmental | developmental toxicity | p.41 |
| SCCS Opinion | NOAEL | =35 | mg/kg bw/d | rat | oral | 2-year | reproductive toxicity | (Ref. 303), p.32 |
| SCCS Opinion | NOAEL | =35 | mg/kg bw/day | - | - | - | reproductive toxicity | p.70 |
| SCCS Opinion | NOAEL | =39 | mg/kg bw/d | rat | oral | 2-year | reproductive toxicity | (Ref. 303), p.32 |
| SCCS Opinion | NOAEL | =39 | mg/kg bw/day | rat | - | chronic | carcinogenicity | p.35 |
| SCCS Opinion | NOAEL | =49 | mg/kg bw/day | rat | oral | 13 weeks | carcinogenicity | p.37 |
| SCCS Opinion | NOAEL | =65 | - | - | - | - | NOAEL study | p.65 |
| SCCS Opinion | NOAEL | =66 | - | - | - | - | NOAEL study | p.66 |
| SCCS Opinion | NOAEL | =67 | - | - | - | - | NOAEL study | p.67 |
| SCCS Opinion | NOAEL | =68 | - | - | - | - | NOAEL study | p.68 |
| SCCS Opinion | NOAEL | =69 | - | - | - | - | NOAEL study | p.69 |
| SCCS Opinion | NOAEL | =70 | - | - | - | - | NOAEL study | p.70 |
| SCCS Opinion | NOAEL | =71 | - | - | - | - | NOAEL study | p.71 |
| SCCS Opinion | NOAEL | =72 | - | - | - | - | NOAEL study | p.72 |
| SCCS Opinion | NOAEL | =73 | - | - | - | - | NOAEL study | p.73 |
| SCCS Opinion | NOAEL | =74 | - | - | - | - | NOAEL study | p.74 |
| SCCS Opinion | NOAEL | =75 | - | - | - | - | NOAEL study | p.75 |
| SCCS Opinion | NOAEL | =76 | - | - | - | - | NOAEL study | p.76 |
| SCCS Opinion | NOAEL | =92 | mg/kg/day | mouse | - | - | NOAEL study | p.25 |
| SCCS Opinion | NOAEL | =92 | mg/kg bw/day | rat | - | chronic | reproductive toxicity | p.71 |
| SCCS Opinion | NOAEL | =93 | - | - | - | - | NOAEL study | p.93 |
| SCCS Opinion | NOAEL | =94 | - | - | - | - | NOAEL study | p.94 |
| SCCS Opinion | NOAEL | =95 | mg/kg bw/day | rat | dermal | 2- year | carcinogenicity | p.35 |
| SCCS Opinion | NOAEL | =95 | - | - | - | - | NOAEL study | p.95 |
| SCCS Opinion | NOAEL | =96 | - | - | - | - | NOAEL study | p.96 |
| SCCS Opinion | NOAEL | =97 | - | - | - | - | NOAEL study | p.97 |
| SCCS Opinion | NOAEL | >98 | % | rat | oral | 24 months | NOAEL study | p.24 |
| SCCS Opinion | NOAEL | =100 | mg/kg | rabbit | - | chronic | reproductive toxicity | p.34 |
| SCCS Opinion | NOAEL | =100 | mg/kg/d | rat | - | developmental | developmental toxicity | p.35 |
| SCCS Opinion | NOAEL | =100 | mg/kg bw/d | rat | oral | - | NOAEL study | p.36 |
| SCCS Opinion | NOAEL | =100 | mg/kg bw | rat | - | developmental | reproductive toxicity | p.37 |
| SCCS Opinion | NOAEL | =100 | % | rabbit | oral | developmental | developmental toxicity | p.47 |
| SCCS Opinion | NOAEL | =100 | mg/kg bw/day | rabbit | oral | 13-day | NOAEL study | p.65 |
| SCCS Opinion | NOAEL | =125 | mg/kg bw/day | - | oral | 2-year | carcinogenicity | p.95 |
| SCCS Opinion | NOAEL | =150 | mg/kg | mouse | - | developmental | developmental toxicity | p.36 |
| SCCS Opinion | NOAEL | =150 | mg/kg bw/day | rat | oral | Prenatal | developmental toxicity | p.73 |
| SCCS Opinion | NOAEL | =200 | mg/kg bw/day | rat | oral | Sub-acute | repeated dose toxicity | p.65 |
| SCCS Opinion | NOAEL | =224 | mg/kg bw/day | rat | - | - | carcinogenicity | p.102 |
| SCCS Opinion | NOAEL | =240 | mg/kg bw/day | mouse | dermal | 4-week | NOAEL study | p.69 |
| SCCS Opinion | NOAEL | =248 | mg/kg bw/day | - | - | - | NOAEL study | p.94 |
| SCCS Opinion | NOAEL | =250 | mg/kg bw/d | mouse | oral | 5d | NOAEL study | p.26 |
| SCCS Opinion | NOAEL | =250 | mg/kg bw/day | rat | oral | chronic | carcinogenicity | p.35 |
| SCCS Opinion | NOAEL | =269 | mg/kg bw/day | rat | - | 2-year | carcinogenicity | p.93 |
| SCCS Opinion | NOAEL | >300 | mg/kg/day | mouse | oral | 5d | NOAEL study | p.26 |
| SCCS Opinion | NOAEL | =300 | mg/kg bw/d | rat | oral | 9 days | NOAEL study | p.36 |
| SCCS Opinion | NOAEL | =300 | mg/kg bw/day | rat | oral | Prenatal | developmental toxicity | p.73 |
| SCCS Opinion | NOAEL | =353 | mg/kg bw/day | rat | oral | 13-week | NOAEL study | p.68 |
| SCCS Opinion | NOAEL | =395 | mg/kg bw/day | rat | - | 2-year | carcinogenicity | p.96 |
| SCCS Opinion | NOAEL | =400 | mg/ kg bw/ day | mouse | oral | Prenatal | developmental toxicity | p.76 |
| SCCS Opinion | NOAEL | =457 | mg/kg | rat | - | - | reproductive toxicity | p.33 |
| SCCS Opinion | NOAEL | =457 | mg/kg bw/day | - | - | - | reproductive toxicity | p.70 |
| SCCS Opinion | NOAEL | =490 | mg/kg bw/day | rat | oral | - | reproductive toxicity | p.70 |
| SCCS Opinion | NOAEL | =500 | mg/kg bw/d | - | - | chronic | reproductive toxicity | p.34 |
| SCCS Opinion | NOAEL | =500 | mg/kg bw/day | dog | oral | Chronic | NOAEL study | p.67 |
| SCCS Opinion | NOAEL | =600 | mg/kg bw/d | mouse | oral | developmental | developmental toxicity | p.36 |
| SCCS Opinion | NOAEL | =600 | mg/kg bw/day | rat | oral | Developmental | developmental toxicity | p.74 |
| SCCS Opinion | NOAEL | =625 | mg/kg bw/day | rat | oral | 13-week | NOAEL study | p.68 |
| SCCS Opinion | NOAEL | =700 | mg/kg bw/day | rat | oral | Developmental | developmental toxicity | p.74 |
| SCCS Opinion | NOAEL | =750 | mg/ kg bw/day | rabbit | oral | Prenatal | developmental toxicity | p.74 |
| SCCS Opinion | NOAEL | =761 | mg/kg bw/day | rat | oral | 3 months | NOAEL study | p.66 |
| SCCS Opinion | NOAEL | =770 | mg/kg bw/day | rat | - | - | NOAEL study | p.96 |
| SCCS Opinion | NOAEL | =1000 | mg/kg bw/day | rat | oral | 3 months | NOAEL study | p.66 |
| SCCS Opinion | NOAEL | =1200 | mg/kg bw/day | rat | oral | Prenatal | developmental toxicity | p.74 |
| SCCS Opinion | NOAEL | =1450 | mg/kg bw/day | mouse | - | - | reproductive toxicity | p.73 |
| SCCS Opinion | NOAEL | =1500 | mg/kg bw/day | - | - | 36 weeks | carcinogenicity | p.96 |
| SCCS Opinion | NOAEL | =1865 | mg/kg bw/day | mouse | dermal | 4-week | repeated dose toxicity | p.69 |
| SCCS Opinion | NOAEL | =2000 | mg/kg bw/day | rat | dermal | 52-week | NOAEL study | p.97 |
| SCCS Opinion | NOAEL | =2100 | mg/kg bw/day | mouse | oral | Developmental | reproductive toxicity | p.72 |
| SCCS Opinion | NOAEL | =3009 | mg/kg bw/day | mouse | - | - | NOAEL study | p.95 |
| SCCS Opinion | NOAEL | =3081 | mg/kg bw/day | - | oral | 96-week | NOAEL study | p.94 |
| SCCS Opinion | NOAEL | =4294 | mg/kg bw/day | mouse | oral | Sub-chronic | repeated dose toxicity | p.67 |
| SCCS Opinion | NOAEL | =5375 | mg/kg bw/day | rat | oral | 13-week | NOAEL study | p.68 |
| SCCS Opinion | NOAEL | =10000 | mg/kg bw/day | rat | oral | Sub-acute | repeated dose toxicity | p.65 |
| SCCS Opinion | NOAEL | =10000 | ppm | rat | - | 2-year | carcinogenicity | p.93 |
| SCCS Opinion | NOAEL | =20000 | ppm | - | oral | 2-year | carcinogenicity | p.95 |
EPA ToxRefDB v3 13 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EPA ToxRefDB v3 | LEL | =100 | mg/kg bw/day | rabbit (new zealand white; New Zealand White) | oral | 7 GD to 19 GD | DEV | study_id=753; toxval_study_source_id=studyid753_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-discharge on cageboard|in life observation-clinical signs-urine, discoloration|pathology microscopic-stomach-hemorrhage|in life observation-clinical signs-abnormal feces|in life observation-mortality-mortality|pathology microscopic-stomach-ulcer|in life observation-clinical signs-perineal soiling|pathology microscopic-kidney-inflammation|pathology microscopic-kidney-degeneration; dose_level=2; study_year=1991; study_citation=Zablotny, C.; Breslin, W.; Kociba, R. (1991) Ortho-Phenylphenol (OPP): Gavage Teratology Study In New Zealand White Rabbits. Lab Project Number: K-001024-045. Unpublished Study Prepared By Dow Chemical Co., Health and Env. Sciences. 309 P.; dsstox_substance_id=DTXSID2021151; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =140 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 15 weeks (premating) to 2 generation | MGR | study_id=756; toxval_study_source_id=studyid756_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-urinary bladder-cellular alteration|in life observation-body weight-body weight|pathology microscopic-urinary bladder-hyperplasia; dose_level=2; study_year=1990; study_citation=Eigenberg, D. (1990) Two-Generation Dietary Reproduction Study in Rats Using Orthophenyl Phenol: Lab Project Number: 85-671-02. Unpublished study prepared by Mobay Corp. 2696 p.; dsstox_substance_id=DTXSID2021151; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =250 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 24 month | CHR | study_id=759; toxval_study_source_id=studyid759_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-liver-accentuated lobular pattern|urinalysis-specific gravity/osmolality-specific gravity/osmolality|organ weight-kidney-relative to body weight|organ weight-liver-relative to body weight|organ weight-brain-relative to body weight|organ weight-liver-absolute|in life observation-body weight-body weight gain|organ weight-brain-absolute|organ weight-adrenal gland-relative to body weight; dose_level=1; study_year=1995; study_citation=Quast, J.; Mcguirk, R. (1995) Ortho-Phenylphenol: Two-Year Dietary Chronic Toxicity/Oncogenicity Study In B6C3F1 Mice: Lab Project Number: K-001024-047. Unpublished Study Prepared By The Dow Chemical Co. 1089 P.; dsstox_substance_id=DTXSID2021151; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =300 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley) | oral | 6 GD to 15 GD | DEV | study_id=755; toxval_study_source_id=studyid755_Adult_F0_F_systemic; toxval_effect_list=in life observation-food consumption-food efficiency|in life observation-food consumption-food consumption|in life observation-body weight-body weight gain|organ weight-liver-absolute|organ weight-liver-relative to body weight; dose_level=2; study_year=1978; study_citation=John, J.; Murray, F.; Crawford, A. et al. (1978) Phase 3 Reformat Of MRIDs 00067616 and 00164362: The Effect(s) Of Orally Administered Orthophenylphenol On Rat Embryonal And Fetal Development: Project Het-K-0001024-33(R). *see study comment*; dsstox_substance_id=DTXSID2021151; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =377 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 90 day | SUB | study_id=752; toxval_study_source_id=studyid752_Adult_F0_M_systemic; toxval_effect_list=organ weight-kidney-relative to body weight|organ weight-liver-relative to body weight|organ weight-testes-relative to body weight|in life observation-body weight-body weight gain|in life observation-water consumption-water consumption|organ weight-brain-relative to body weight|in life observation-body weight-body weight|organ weight-urinary bladder-absolute|organ weight-lung-relative to body weight|organ weight-spleen-relative to body weight|organ weight-adrenal gland-relative to body weight|in life observation-food consumption-food consumption; dose_level=1; study_year=1981; study_citation=Nakamura, K.; Iguchi, S.; Hiraga, K. (1982; reformatted 1990) Dow Chemical U S A Phase 3 Reformat Of Mrid 40760207. Subacute Toxicity Of O-Phenylphenol By Food Administration To Male Rats. Prepared By Tokyo Metropolitan Research Lab. 25 P.; dsstox_substance_id=DTXSID2021151; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =490 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 15 weeks (premating) to 2 generation | MGR | study_id=756; toxval_study_source_id=studyid756_Adult_F1_F_systemic; toxval_effect_list=in life observation-body weight-body weight; dose_level=3; study_year=1990; study_citation=Eigenberg, D. (1990) Two-Generation Dietary Reproduction Study in Rats Using Orthophenyl Phenol: Lab Project Number: 85-671-02. Unpublished study prepared by Mobay Corp. 2696 p.; dsstox_substance_id=DTXSID2021151; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | >700 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley) | oral | 6 GD to 15 GD | DEV | study_id=755; toxval_study_source_id=studyid755_Fetal_Fetal_MF_NA; dose_level=3; study_year=1978; study_citation=John, J.; Murray, F.; Crawford, A. et al. (1978) Phase 3 Reformat Of MRIDs 00067616 and 00164362: The Effect(s) Of Orally Administered Orthophenylphenol On Rat Embryonal And Fetal Development: Project Het-K-0001024-33(R). *see study comment*; dsstox_substance_id=DTXSID2021151; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =250 | mg/kg bw/day | rabbit (new zealand white; New Zealand White) | oral | 7 GD to 19 GD | DEV | study_id=753; toxval_study_source_id=studyid753_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-abnormal feces|in life observation-mortality-mortality|in life observation-clinical signs-perineal soiling; dose_level=3; study_year=1991; study_citation=Zablotny, C.; Breslin, W.; Kociba, R. (1991) Ortho-Phenylphenol (OPP): Gavage Teratology Study In New Zealand White Rabbits. Lab Project Number: K-001024-045. Unpublished Study Prepared By Dow Chemical Co., Health and Env. Sciences. 309 P.; dsstox_substance_id=DTXSID2021151; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =763 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 90 day | SUB | study_id=752; toxval_study_source_id=studyid752_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight gain|in life observation-body weight-body weight; dose_level=2; study_year=1981; study_citation=Nakamura, K.; Iguchi, S.; Hiraga, K. (1982; reformatted 1990) Dow Chemical U S A Phase 3 Reformat Of Mrid 40760207. Subacute Toxicity Of O-Phenylphenol By Food Administration To Male Rats. Prepared By Tokyo Metropolitan Research Lab. 25 P.; dsstox_substance_id=DTXSID2021151; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | >0 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 90 day | SUB | study_id=752; toxval_study_source_id=studyid752_Adult_F0_M_systemic; toxval_effect_list=organ weight-adrenal gland-relative to body weight|organ weight-brain-relative to body weight|organ weight-liver-relative to body weight|organ weight-urinary bladder-absolute|in life observation-body weight-body weight|organ weight-lung-relative to body weight|in life observation-water consumption-water consumption|organ weight-spleen-relative to body weight|organ weight-kidney-relative to body weight|in life observation-food consumption-food consumption|organ weight-testes-relative to body weight|in life observation-body weight-body weight gain; dose_level=0; study_year=1981; study_citation=Nakamura, K.; Iguchi, S.; Hiraga, K. (1982; reformatted 1990) Dow Chemical U S A Phase 3 Reformat Of Mrid 40760207. Subacute Toxicity Of O-Phenylphenol By Food Administration To Male Rats. Prepared By Tokyo Metropolitan Research Lab. 25 P.; dsstox_substance_id=DTXSID2021151; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =25 | mg/kg bw/day | rabbit (new zealand white; New Zealand White) | oral | 7 GD to 19 GD | DEV | study_id=753; toxval_study_source_id=studyid753_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-abnormal feces|in life observation-clinical signs-urine, discoloration|pathology microscopic-stomach-hemorrhage|pathology microscopic-kidney-degeneration|in life observation-clinical signs-discharge on cageboard|pathology microscopic-stomach-ulcer|in life observation-clinical signs-perineal soiling|in life observation-mortality-mortality|pathology microscopic-kidney-inflammation; dose_level=1; study_year=1991; study_citation=Zablotny, C.; Breslin, W.; Kociba, R. (1991) Ortho-Phenylphenol (OPP): Gavage Teratology Study In New Zealand White Rabbits. Lab Project Number: K-001024-045. Unpublished Study Prepared By Dow Chemical Co., Health and Env. Sciences. 309 P.; dsstox_substance_id=DTXSID2021151; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =40 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 15 weeks (premating) to 2 generation | MGR | study_id=756; toxval_study_source_id=studyid756_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|pathology microscopic-urinary bladder-cellular alteration|pathology microscopic-urinary bladder-hyperplasia; dose_level=1; study_year=1990; study_citation=Eigenberg, D. (1990) Two-Generation Dietary Reproduction Study in Rats Using Orthophenyl Phenol: Lab Project Number: 85-671-02. Unpublished study prepared by Mobay Corp. 2696 p.; dsstox_substance_id=DTXSID2021151; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =100 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley) | oral | 6 GD to 15 GD | DEV | study_id=755; toxval_study_source_id=studyid755_Adult_F0_F_systemic; toxval_effect_list=in life observation-food consumption-food efficiency|organ weight-liver-relative to body weight|organ weight-liver-absolute|in life observation-body weight-body weight gain|in life observation-food consumption-food consumption; dose_level=1; study_year=1978; study_citation=John, J.; Murray, F.; Crawford, A. et al. (1978) Phase 3 Reformat Of MRIDs 00067616 and 00164362: The Effect(s) Of Orally Administered Orthophenylphenol On Rat Embryonal And Fetal Development: Project Het-K-0001024-33(R). *see study comment*; dsstox_substance_id=DTXSID2021151; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ToxValDB ECOTOX 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | LOEL | =2 | % diet | Rat | oral | chronic; 168 days | chronic | LONG_REF=Cancer Lett.48(1): 19-28 Shibata,M.A., H. Tanaka, M. Yamada, S. Tamano, and S. Fukushima Proliferative Response of Renal Pelvic Epithelium in Rats to Oral Administration of Ortho-Phenylphenol, Sodium Ortho-Phenylphenate and Diphenyl 1989; TITLE=Proliferative Response of Renal Pelvic Epithelium in Rats to Oral Administration of Ortho-Phenylphenol, Sodium Ortho-Phenylphenate and Diphenyl; AUTHOR=Shibata,M.A., H. Tanaka, M. Yamada, S. Tamano, and S. Fukushima; DOI=10.1016/0304-3835(89)90198-5; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=96226; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Genetics: DNA synthesis rate|Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|other; STUDY_GROUP=ECOTOX:15599614:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=da703b8d02e579ee447e59ad31052880 |
| ToxValDB ECOTOX | LOEL | =300 | mg/kg bw/day | Rat | oral | short-term; 10 days | short-term | LONG_REF=- | J. Pestic. Sci.3:365-370 Kaneda,M., S. Teramoto, A. Shingu, and Y. Shirasu Teratogenicity and Dominant-Lethal Studies with o-Phenylphenol 1978; TITLE=Teratogenicity and Dominant-Lethal Studies with o-Phenylphenol; AUTHOR=Kaneda,M., S. Teramoto, A. Shingu, and Y. Shirasu; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=35292; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1978; ORIGINAL_YEAR=1978; TOXICOLOGICAL_EFFECT=Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX:15613586:F:-adult; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=0a05aa302b8ded8b4db4472b879b9233 |
| ToxValDB ECOTOX | LOEL | =2000 | mg/kg bw/day | Mouse | oral | acute; 1 days | acute | LONG_REF=Mutat. Res.395(2/3): 189-198 Sasaki,Y.F., A. Saga, M. Akasaka, K. Yoshida, E. Nishidate, Y.Q. Su, N. Matsusaka, and S. Tsuda In Vivo Genotoxicity of Ortho-Phenylphenol, Biphenyl, and Thiabendazole Detected in Multiple Mouse Organs by the Alkaline Single Cell Gel Electrophoresis Assay 1997; TITLE=In Vivo Genotoxicity of Ortho-Phenylphenol, Biphenyl, and Thiabendazole Detected in Multiple Mouse Organs by the Alkaline Single Cell Gel Electrophoresis Assay; AUTHOR=Sasaki,Y.F., A. Saga, M. Akasaka, K. Yoshida, E. Nishidate, Y.Q. Su, N. Matsusaka, and S. Tsuda; DOI=10.1016/s1383-5718(97)00168-x; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=95361; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Genetics: Damage; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15595032:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4ace0dc5f4e412cb24c65d32410a3ec9 |
| ToxValDB ECOTOX | NOEL | =2 | % | Rat | oral | subchronic; 56 days | subchronic | LONG_REF=Toxicol. Appl. Pharmacol.99(1): 37-49 Shibata,M.A., M. Yamada, H. Tanaka, M. Kagawa, and S. Fukushima Changes in Urine Composition, Bladder Epithelial Morphology, and DNA Synthesis in Male F344 Rats in Response to Ingestion of Bladder Tumor Promoters 1989; TITLE=Changes in Urine Composition, Bladder Epithelial Morphology, and DNA Synthesis in Male F344 Rats in Response to Ingestion of Bladder Tumor Promoters; AUTHOR=Shibata,M.A., M. Yamada, H. Tanaka, M. Kagawa, and S. Fukushima; DOI=10.1016/0041-008x(89)90109-9; QUALITY=Control type: Multiple entries; EXTERNAL_SOURCE_ID=106692; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Biochemistry: pH|Genetics: DNA synthesis rate; TOXICOLOGICAL_EFFECT_CATEGORY=other|urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15609983_15609984:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=586be227872d146791bfdd5325b149c7 |
| ToxValDB ECOTOX | NOEL | =150 | mg/kg bw/day | Mouse | oral | short-term; 10 days | short-term | LONG_REF=- | J. Pestic. Sci.3:365-370 Kaneda,M., S. Teramoto, A. Shingu, and Y. Shirasu Teratogenicity and Dominant-Lethal Studies with o-Phenylphenol 1978; TITLE=Teratogenicity and Dominant-Lethal Studies with o-Phenylphenol; AUTHOR=Kaneda,M., S. Teramoto, A. Shingu, and Y. Shirasu; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=35292; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1978; ORIGINAL_YEAR=1978; TOXICOLOGICAL_EFFECT=Material body weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX:15613426:F:-adult; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=9250b3f31bcaf169662e3ecd7029616d |
| ToxValDB ECOTOX | NOEL | =300 | mg/kg bw/day | Rat | oral | short-term; 10 days | reproduction developmental | LONG_REF=- | J. Pestic. Sci.3:365-370 Kaneda,M., S. Teramoto, A. Shingu, and Y. Shirasu Teratogenicity and Dominant-Lethal Studies with o-Phenylphenol 1978; TITLE=Teratogenicity and Dominant-Lethal Studies with o-Phenylphenol; AUTHOR=Kaneda,M., S. Teramoto, A. Shingu, and Y. Shirasu; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=35292; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1978; ORIGINAL_YEAR=1978; TOXICOLOGICAL_EFFECT=Fetus: Growth: Weight | Fetus: Morphology: External, skeletal, and internal abnormalities; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX:15613587:M/F:-fetus; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=38ba2be1c58182567716a5bf8e5c57ea |
| ToxValDB ECOTOX | NOEL | =500 | mg/kg bw/day | Mouse | oral | short-term; 5 days | developmental | LONG_REF=- | J. Pestic. Sci.3:365-370 Kaneda,M., S. Teramoto, A. Shingu, and Y. Shirasu Teratogenicity and Dominant-Lethal Studies with o-Phenylphenol 1978; TITLE=Teratogenicity and Dominant-Lethal Studies with o-Phenylphenol; AUTHOR=Kaneda,M., S. Teramoto, A. Shingu, and Y. Shirasu; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=35292; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1978; ORIGINAL_YEAR=1978; TOXICOLOGICAL_EFFECT=Genetics: Dominant lethal mutations; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15613427:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=465474ae15945053ea03a498113965fd |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =19.25 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630089:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bfe5d964f4d74e614ef056286ceabcc0 |
ToxValDB ToxRefDB 11 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ToxRefDB | LEL | =140 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Eigenberg, D. (1990) Two-Generation Dietary Reproduction Study in Rats Using Orthophenyl Phenol: Lab Project Number: 85-671-02. Unpublished study prepared by Mobay Corp. 2696 p.; TITLE=Two-Generation Dietary Reproduction Study in Rats Using Orthophenyl Phenol: Lab Project Number: 85-671-02; AUTHOR=Eigenberg, D; EXTERNAL_SOURCE_ID=756; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-urinary bladder-cellular alteration|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-urinary bladder-hyperplasia; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15682384_15682385_15682386_15682387:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_28dde25ea774fce8bf28d3a1f496a3d4 |
| ToxValDB ToxRefDB | LEL | >250 | mg/kg bw/day | Rabbit | oral | short-term (developmental); 13 days | developmental | LONG_REF=Zablotny, C.; Breslin, W.; Kociba, R. (1991) Ortho-Phenylphenol (OPP): Gavage Teratology Study In New Zealand White Rabbits. Lab Project Number: K-001024-045. Unpublished Study Prepared By Dow Chemical Co., Health & Env. Sciences. 309 P.; TITLE=Ortho-Phenylphenol (OPP): Gavage Teratology Study In New Zealand White Rabbits; AUTHOR=Zablotny, C.; Breslin, W.; Kociba, R; EXTERNAL_SOURCE_ID=753; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; STUDY_GROUP=ToxRefDB_dup_-_15682372_15682373_15682374_15682375:M/F:fetusfetal; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1897b45e6aa8564791fdfff9e4748f3d |
| ToxValDB ToxRefDB | LEL | =300 | mg/kg bw/day | Dog | oral | chronic; 52 weeks | chronic | LONG_REF=Cosse, P.; Stebbins, K.; Stott, W.; Et Al. (1990) Ortho-Phenylphen- Ol: Palatability/Probe, Four-Week And One-Year Oral Toxicity Studies In Beagle Dogs: Lab Project Number: K-001024-038: K-001024-038A: K-001024-039. Unpublished Study Prepared By Dow Chemi; TITLE=Ortho-Phenylphen- Ol: Palatability/Probe, Four-Week And One-Year Oral Toxicity Studies In Beagle Dogs: Lab Project Number: K-001024-038: K-001024-038A: K-001024-039; AUTHOR=Cosse, P.; Stebbins, K.; Stott, W.; Et Al; EXTERNAL_SOURCE_ID=757; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=systemic: in life observation-food consumption-food consumption|systemic: in life observation-body weight-body weight gain|systemic: in life observation-food consumption-food efficiency|systemic: in life observation-clinical signs-emesis; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15682416_15682417_15682418_15682419:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f405ea706e2281fef7129695aa40f9a3 |
| ToxValDB ToxRefDB | LEL | =377 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=Nakamura, K.; Iguchi, S.; Hiraga, K. (1982; reformatted 1990) Dow Chemical U S A Phase 3 Reformat Of Mrid 40760207. Subacute Toxicity Of O-Phenylphenol By Food Administration To Male Rats. Prepared By Tokyo Metropolitan Research Lab. 25 P.; TITLE=Dow Chemical U S A Phase 3 Reformat Of Mrid 40760207. Subacute Toxicity Of O-Phenylphenol By Food Administration To Male Rats; AUTHOR=Nakamura, K.; Iguchi, S.; Hiraga, K; EXTERNAL_SOURCE_ID=752; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1981; ORIGINAL_YEAR=1981; TOXICOLOGICAL_EFFECT=systemic: organ weight-kidney-relative to body weight|systemic: organ weight-liver-relative to body weight|systemic: in life observation-water consumption-water consumption|systemic: organ weight-brain-relative to body weight|systemic: organ weight-testes-relative to body weight|systemic: in life observation-body weight-body weight|systemic: in life observation-body weight-body weight gain|systemic: organ weight-urinary bladder-absolute|systemic: organ weight-lung-relative to body weight|systemic: organ weight-adrenal gland-relative to body weight|systemic: organ weight-spleen-relative to body weight|systemic: in life observation-food consumption-food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15682365_15682366_15682367:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_83639ecc1c1e75922c5a3051525a6b46 |
| ToxValDB ToxRefDB | LEL | =490 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Eigenberg, D. (1990) Two-Generation Dietary Reproduction Study in Rats Using Orthophenyl Phenol: Lab Project Number: 85-671-02. Unpublished study prepared by Mobay Corp. 2696 p.; TITLE=Two-Generation Dietary Reproduction Study in Rats Using Orthophenyl Phenol: Lab Project Number: 85-671-02; AUTHOR=Eigenberg, D; EXTERNAL_SOURCE_ID=756; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15682392_15682393_15682394_15682395:F:F1adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2b63a819b5d955eec22dfae90a291861 |
| ToxValDB ToxRefDB | LEL | >700 | mg/kg bw/day | Rat | oral | short-term (developmental); 10 days | developmental | LONG_REF=John, J.; Murray, F.; Crawford, A. et al. (1978) Phase 3 Reformat Of MRIDs 00067616 and 00164362: The Effect(s) Of Orally Administered Orthophenylphenol On Rat Embryonal And Fetal Development: Project Het-K-0001024-33(R). *see study comment*; TITLE=Phase 3 Reformat Of MRIDs 00067616 and 00164362: The Effect(s) Of Orally Administered Orthophenylphenol On Rat Embryonal And Fetal Development; AUTHOR=John, J.; Murray, F.; Crawford, A. et al; EXTERNAL_SOURCE_ID=755; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1978; ORIGINAL_YEAR=1978; STUDY_GROUP=ToxRefDB_dup_-_15682380_15682381_15682382_15682383:M/F:fetusfetal; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e099b8589b524662f096e94fea690388 |
| ToxValDB ToxRefDB | LOAEL | =250 | mg/kg bw/day | Rabbit | oral | short-term (developmental); 13 days | reproduction developmental | LONG_REF=Zablotny, C.; Breslin, W.; Kociba, R. (1991) Ortho-Phenylphenol (OPP): Gavage Teratology Study In New Zealand White Rabbits. Lab Project Number: K-001024-045. Unpublished Study Prepared By Dow Chemical Co., Health & Env. Sciences. 309 P.; TITLE=Ortho-Phenylphenol (OPP): Gavage Teratology Study In New Zealand White Rabbits; AUTHOR=Zablotny, C.; Breslin, W.; Kociba, R; EXTERNAL_SOURCE_ID=753; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=systemic: in life observation-mortality-mortality|systemic: in life observation-clinical signs-perineal soiling|systemic: in life observation-clinical signs-abnormal feces; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|mortality/survival; STUDY_GROUP=ToxRefDB_dup_-_15682368_15682369_15682370_15682371:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e0e5d4bb29878f8e632ae2ec1587914f |
| ToxValDB ToxRefDB | LOAEL | =763 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=Nakamura, K.; Iguchi, S.; Hiraga, K. (1982; reformatted 1990) Dow Chemical U S A Phase 3 Reformat Of Mrid 40760207. Subacute Toxicity Of O-Phenylphenol By Food Administration To Male Rats. Prepared By Tokyo Metropolitan Research Lab. 25 P.; TITLE=Dow Chemical U S A Phase 3 Reformat Of Mrid 40760207. Subacute Toxicity Of O-Phenylphenol By Food Administration To Male Rats; AUTHOR=Nakamura, K.; Iguchi, S.; Hiraga, K; EXTERNAL_SOURCE_ID=752; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1981; ORIGINAL_YEAR=1981; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: in life observation-body weight-body weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15682365_15682366_15682367:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f8c96ff9ad9466808cde749898cc8955 |
| ToxValDB ToxRefDB | NEL | =25 | mg/kg bw/day | Rabbit | oral | short-term (developmental); 13 days | reproduction developmental | LONG_REF=Zablotny, C.; Breslin, W.; Kociba, R. (1991) Ortho-Phenylphenol (OPP): Gavage Teratology Study In New Zealand White Rabbits. Lab Project Number: K-001024-045. Unpublished Study Prepared By Dow Chemical Co., Health & Env. Sciences. 309 P.; TITLE=Ortho-Phenylphenol (OPP): Gavage Teratology Study In New Zealand White Rabbits; AUTHOR=Zablotny, C.; Breslin, W.; Kociba, R; EXTERNAL_SOURCE_ID=753; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-urine, discoloration|systemic: pathology microscopic-kidney-degeneration|systemic: pathology microscopic-stomach-ulcer|systemic: in life observation-clinical signs-perineal soiling|systemic: in life observation-mortality-mortality|systemic: in life observation-clinical signs-abnormal feces|systemic: pathology microscopic-stomach-hemorrhage|systemic: pathology microscopic-kidney-inflammation|systemic: in life observation-clinical signs-discharge on cageboard; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|mortality/survival|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15682368_15682369_15682370_15682371:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9faf77e6c44882609e18111b5011d160 |
| ToxValDB ToxRefDB | NEL | =40 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Eigenberg, D. (1990) Two-Generation Dietary Reproduction Study in Rats Using Orthophenyl Phenol: Lab Project Number: 85-671-02. Unpublished study prepared by Mobay Corp. 2696 p.; TITLE=Two-Generation Dietary Reproduction Study in Rats Using Orthophenyl Phenol: Lab Project Number: 85-671-02; AUTHOR=Eigenberg, D; EXTERNAL_SOURCE_ID=756; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: pathology microscopic-urinary bladder-cellular alteration|systemic: pathology microscopic-urinary bladder-hyperplasia; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15682384_15682385_15682386_15682387:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fb3c6feb3e37a07c61c349e62b78a207 |
| ToxValDB ToxRefDB | NEL | =100 | mg/kg bw/day | Rat | oral | short-term (developmental); 10 days | reproduction developmental | LONG_REF=John, J.; Murray, F.; Crawford, A. et al. (1978) Phase 3 Reformat Of MRIDs 00067616 and 00164362: The Effect(s) Of Orally Administered Orthophenylphenol On Rat Embryonal And Fetal Development: Project Het-K-0001024-33(R). *see study comment*; TITLE=Phase 3 Reformat Of MRIDs 00067616 and 00164362: The Effect(s) Of Orally Administered Orthophenylphenol On Rat Embryonal And Fetal Development; AUTHOR=John, J.; Murray, F.; Crawford, A. et al; EXTERNAL_SOURCE_ID=755; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1978; ORIGINAL_YEAR=1978; TOXICOLOGICAL_EFFECT=systemic: in life observation-food consumption-food efficiency|systemic: organ weight-liver-absolute|systemic: organ weight-liver-relative to body weight|systemic: in life observation-body weight-body weight gain|systemic: in life observation-food consumption-food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15682376_15682377_15682378_15682379:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0d1d3f86d9ead8a2ffe3dfda507da1c6 |
ToxValDB Uterotrophic Hershberger DB 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Uterotrophic Hershberger DB | NOEL | =250 | mg/kg bw/day | Rat | oral | short-term; 10 days | Hershberger | LONG_REF=O-phenylphenol: Data Evaluation Records (DERs) for EDSP Tier 1 Assays Docket Number: EPA-HQ-OPP-2013-0524. Available at: http://www.regulations.gov/contentStreamer?documentId=EPA-HQ-OPP-2013-0524-0010&disposition=attachment&contentType=pdf; TITLE=O-phenylphenol: Data Evaluation Records (DERs) for EDSP Tier 1 Assays Docket Number: EPA-HQ-OPP-2013-0524; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40a; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=inactive|Negative|Negative|anti-androgenic|decrease in ASTs, NS (1.6 d) delay PPS; accompanied by "minor" increase in liver wt and 8% decrease in BW; NOTE AR binding and ARTA (OSRI) positive; STUDY_GROUP=Uterotrophic Hershberger DB:15714277:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_64e8869c42950b46a900bee46f4d1c23 |
Regulatory source 157 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | - | 2 | % | - | oral | 96-week | - | p.94 |
| Regulatory source | - | 2.5 | % | rat | oral | - | - | p.80 |
| Regulatory source | - | 2.5 | % | rat | oral | 13-week | - | p.66 |
| Regulatory source | - | 4 | % | rat | oral | - | - | p.80 |
| Regulatory source | - | 4 | % | - | - | 13 weeks | - | p.80 |
| Regulatory source | - | 4 | % | mouse | oral | 13-week | - | p.67 |
| Regulatory source | - | 4 | % | rat | oral | 13-week | - | p.68 |
| Regulatory source | - | 65 | - | - | - | - | - | p.65 |
| Regulatory source | - | 66 | - | - | - | - | - | p.66 |
| Regulatory source | - | 67 | - | - | - | - | - | p.67 |
| Regulatory source | - | 68 | - | - | - | - | - | p.68 |
| Regulatory source | - | 69 | - | - | - | - | - | p.69 |
| Regulatory source | - | 70 | - | - | - | - | - | p.70 |
| Regulatory source | - | 71 | - | - | - | - | - | p.71 |
| Regulatory source | - | 72 | - | - | - | - | - | p.72 |
| Regulatory source | - | 73 | - | - | - | - | - | p.73 |
| Regulatory source | - | 74 | - | - | - | - | - | p.74 |
| Regulatory source | - | 75 | - | - | - | - | - | p.75 |
| Regulatory source | - | 76 | - | - | - | - | - | p.76 |
| Regulatory source | - | 92 | mg/kg/day | mouse | - | - | - | p.25 |
| Regulatory source | - | 93 | - | - | - | - | - | p.93 |
| Regulatory source | - | 94 | - | - | - | - | - | p.94 |
| Regulatory source | - | 95 | - | - | - | - | - | p.95 |
| Regulatory source | - | 96 | - | - | - | - | - | p.96 |
| Regulatory source | - | 97 | - | - | - | - | - | p.97 |
| Regulatory source | - | >98 | % | rat | oral | 24 months | - | p.24 |
| Regulatory source | - | 100 | mg/kg bw/d | rat | oral | - | - | p.36 |
| Regulatory source | - | 100 | % | - | oral | - | - | p.48 |
| Regulatory source | - | 100 | mg/kg bw/day | rabbit | oral | 13-day | - | p.65 |
| Regulatory source | - | 100 | mg/kg bw/day | dog | oral | 4-week | - | p.65 |
| Regulatory source | - | 100 | mg/kg bw/day | dog | oral | 1 year | - | p.67 |
| Regulatory source | - | 200 | mg/kg bw/day | rat | oral | 6 months | - | p.66 |
| Regulatory source | - | 200 | mg/kg bw/day | dog | oral | Chronic | - | p.67 |
| Regulatory source | - | 200 | mg/kg bw/day | rat | oral | 32-day | - | p.65 |
| Regulatory source | - | 200 | mg/kg bw/day | dog | oral | 1-year | - | p.67 |
| Regulatory source | - | 224 | mg/kg bw/day | rat | - | - | - | p.96 |
| Regulatory source | - | 240 | mg/kg bw/day | mouse | dermal | 4-week | - | p.69 |
| Regulatory source | - | 248 | mg/kg bw/day | - | - | - | - | p.94 |
| Regulatory source | - | 250 | mg/kg bw/d | mouse | oral | 5d | - | p.26 |
| Regulatory source | - | >300 | mg/kg/day | mouse | oral | 5d | - | p.26 |
| Regulatory source | - | 300 | mg/kg bw/d | rat | oral | 9 days | - | p.36 |
| Regulatory source | - | 300 | mg/kg bw/day | dog | oral | 4-week | - | p.65 |
| Regulatory source | - | 300 | mg/kg bw/day | dog | oral | 1 year | - | p.67 |
| Regulatory source | - | 353 | mg/kg bw/day | rat | oral | 13-week | - | p.68 |
| Regulatory source | - | 500 | mg/kg bw/day | dog | oral | Chronic | - | p.67 |
| Regulatory source | - | 500 | mg/kg bw/day | rat | oral | 6 months | - | p.66 |
| Regulatory source | - | 500 | mg/kg bw/day | dog | oral | 1-year | - | p.67 |
| Regulatory source | - | 625 | mg/kg bw/day | rat | oral | 13-week | - | p.68 |
| Regulatory source | - | 761 | mg/kg bw/day | rat | oral | 3 months | - | p.66 |
| Regulatory source | - | 761 | mg/kg bw/day | rat | oral | 13-week | - | p.66 |
| Regulatory source | - | 770 | mg/kg bw/day | rat | - | - | - | p.96 |
| Regulatory source | - | 1000 | mg/kg bw/day | rat | oral | 3 months | - | p.66 |
| Regulatory source | - | 1000 | mg/kg bw/day | rabbit | oral | 13-day | - | p.65 |
| Regulatory source | - | 1000 | mg/kg bw/day | rat | - | - | - | p.97 |
| Regulatory source | - | 2000 | mg/kg bw/day | rat | dermal | 52-week | - | p.97 |
| Regulatory source | - | 2000 | mg/kg bw/day | rat | oral | 1-month | - | p.65 |
| Regulatory source | - | 2000 | mg/kg bw/day | rat | oral | 3 months | - | p.66 |
| Regulatory source | - | 2000 | mg/kg bw/day | rat | oral | 4-week | - | p.67 |
| Regulatory source | - | 2000 | mg/kg bw/day | rat | oral | 90-day | - | p.68 |
| Regulatory source | - | 3009 | mg/kg bw/day | mouse | - | - | - | p.95 |
| Regulatory source | - | 3081 | mg/kg bw/day | - | oral | 96-week | - | p.94 |
| Regulatory source | - | 4294 | mg/kg bw/day | mouse | oral | 13-week | - | p.67 |
| Regulatory source | - | 5375 | mg/kg bw/day | rat | oral | 13-week | - | p.68 |
| Regulatory source | - | 5375 | mg/kg bw/day | - | - | - | - | p.68 |
| Regulatory source | carcinogenicity | 2 | % | rat | - | 2-year | carcinogenicity | p.94 |
| Regulatory source | carcinogenicity | 2.5 | % | rat | oral | 91-week | carcinogenicity | p.93 |
| Regulatory source | carcinogenicity | 4 | % | rat | oral | 91-week | carcinogenicity | p.95 |
| Regulatory source | carcinogenicity | 39 | mg/kg bw/day | rat | - | chronic | carcinogenicity | p.35 |
| Regulatory source | carcinogenicity | 39 | mg/kg bw/day | rat | - | 91-week | carcinogenicity | p.35 |
| Regulatory source | carcinogenicity | 49 | mg/kg bw/day | rat | oral | 13 weeks | carcinogenicity | p.37 |
| Regulatory source | carcinogenicity | 49 | mg/kg bw/day | rat | - | 2-year | carcinogenicity | p.93 |
| Regulatory source | carcinogenicity | 49 | mg/kg bw/day | rat | - | - | carcinogenicity | p.99 |
| Regulatory source | carcinogenicity | 95 | mg/kg bw/day | rat | dermal | 2- year | carcinogenicity | p.35 |
| Regulatory source | carcinogenicity | 95 | mg/kg bw/day | rat | - | 56-week | carcinogenicity | p.96 |
| Regulatory source | carcinogenicity | 95 | mg/kg bw/day | rat | oral | 2-year | carcinogenicity | p.96 |
| Regulatory source | carcinogenicity | 100 | mg/kg bw/day | rat | dermal | 2-year | carcinogenicity | p.94 |
| Regulatory source | carcinogenicity | 100 | mg/kg bw/day | rat | - | 2-year | carcinogenicity | p.94 |
| Regulatory source | carcinogenicity | 125 | mg/kg bw/day | - | oral | 2-year | carcinogenicity | p.95 |
| Regulatory source | carcinogenicity | 125 | mg/kg bw/day | rat | oral | 91-week | carcinogenicity | p.95 |
| Regulatory source | carcinogenicity | 224 | mg/kg bw/day | rat | - | - | carcinogenicity | p.102 |
| Regulatory source | carcinogenicity | 250 | mg/kg bw/day | rat | oral | chronic | carcinogenicity | p.35 |
| Regulatory source | carcinogenicity | 250 | mg/kg bw/day | rat | oral | 2-year | carcinogenicity | p.93 |
| Regulatory source | carcinogenicity | 250 | mg/kg bw/day | rat | - | - | carcinogenicity | p.98 |
| Regulatory source | carcinogenicity | 250 | mg/kg bw/day | mouse | - | 2-year | carcinogenicity | p.93 |
| Regulatory source | carcinogenicity | 269 | mg/kg bw/day | rat | - | 2-year | carcinogenicity | p.93 |
| Regulatory source | carcinogenicity | 269 | mg/kg bw/day | rat | oral | 91-week | carcinogenicity | p.93 |
| Regulatory source | carcinogenicity | 395 | mg/kg bw/day | rat | - | 2-year | carcinogenicity | p.96 |
| Regulatory source | carcinogenicity | 1000 | mg/kg bw/day | mouse | oral | Chronic | carcinogenicity | p.93 |
| Regulatory source | carcinogenicity | 1000 | mg/kg bw/day | mouse | - | 2-year | carcinogenicity | p.93 |
| Regulatory source | carcinogenicity | 1500 | mg/kg bw/day | - | - | 36 weeks | carcinogenicity | p.96 |
| Regulatory source | carcinogenicity | 3009 | mg/kg bw/day | mouse | - | - | carcinogenicity | p.95 |
| Regulatory source | carcinogenicity | 10000 | ppm | rat | - | 2-year | carcinogenicity | p.93 |
| Regulatory source | carcinogenicity | 20000 | ppm | - | oral | 2-year | carcinogenicity | p.95 |
| Regulatory source | carcinogenicity | 20000 | ppm | rat | oral | 2-year | carcinogenicity | p.96 |
| Regulatory source | carcinogenicity | 20000 | ppm | - | - | 112-week | carcinogenicity | p.96 |
| Regulatory source | developmental toxicity | 22.4 | mg/kg bw/day | rat | oral | 104-week | developmental toxicity | p.37 |
| Regulatory source | developmental toxicity | 25 | mg/kg/d | rat | - | developmental | developmental toxicity | p.35 |
| Regulatory source | developmental toxicity | 25 | mg/kg bw/d | rat | - | Developmental | developmental toxicity | p.37 |
| Regulatory source | developmental toxicity | 25 | mg/kg bw/d | - | - | developmental | developmental toxicity | p.38 |
| Regulatory source | developmental toxicity | 25 | mg/kg bw/d | rabbit | - | developmental | developmental toxicity | p.47 |
| Regulatory source | developmental toxicity | =25 | mg/kg bw/d | rabbit | oral | developmental | developmental toxicity | p.47 |
| Regulatory source | developmental toxicity | 25 | mg/kg bw/day | rat | - | developmental | developmental toxicity | p.31 |
| Regulatory source | developmental toxicity | 25 | mg/kg bw/d | rat | - | 104-week | developmental toxicity | p.37 |
| Regulatory source | developmental toxicity | 25 | mg/kg bw/day | - | - | developmental | developmental toxicity | p.76 |
| Regulatory source | developmental toxicity | 100 | mg/kg/d | rat | - | developmental | developmental toxicity | p.35 |
| Regulatory source | developmental toxicity | 100 | mg/kg bw | rat | - | Developmental | developmental toxicity | p.37 |
| Regulatory source | developmental toxicity | 100 | % | rabbit | oral | developmental | developmental toxicity | p.47 |
| Regulatory source | developmental toxicity | 150 | mg/kg | mouse | - | developmental | developmental toxicity | p.36 |
| Regulatory source | developmental toxicity | 150 | mg/kg bw/day | rat | oral | Prenatal | developmental toxicity | p.73 |
| Regulatory source | developmental toxicity | 150 | mg/kg bw/day | rat | oral | 9 days | developmental toxicity | p.74 |
| Regulatory source | developmental toxicity | 250 | mg/kg bw/day | rabbit | oral | Prenatal | developmental toxicity | p.74 |
| Regulatory source | developmental toxicity | 250 | mg/kg bw/day | - | - | developmental | developmental toxicity | p.76 |
| Regulatory source | developmental toxicity | 300 | mg/kg bw/day | rat | oral | Prenatal | developmental toxicity | p.73 |
| Regulatory source | developmental toxicity | 400 | mg/ kg bw/ day | mouse | oral | Prenatal | developmental toxicity | p.76 |
| Regulatory source | developmental toxicity | 600 | mg/kg bw/d | mouse | oral | developmental | developmental toxicity | p.36 |
| Regulatory source | developmental toxicity | 600 | mg/kg bw/day | rat | oral | Developmental | developmental toxicity | p.74 |
| Regulatory source | developmental toxicity | 700 | mg/kg bw/day | rat | oral | Developmental | developmental toxicity | p.74 |
| Regulatory source | developmental toxicity | 700 | mg/kg bw/day | rat | oral | Prenatal | developmental toxicity | p.73 |
| Regulatory source | developmental toxicity | 750 | mg/ kg bw/day | rabbit | oral | Prenatal | developmental toxicity | p.74 |
| Regulatory source | developmental toxicity | 1200 | mg/kg bw/day | rat | oral | Prenatal | developmental toxicity | p.74 |
| Regulatory source | developmental toxicity | 1450 | mg/kg bw/day | mouse | oral | Prenatal | developmental toxicity | p.72 |
| Regulatory source | irritation | 100 | mg/kg bw/day | rat | dermal | 21-day | irritation | p.69 |
| Regulatory source | irritation | 1000 | mg/kg bw/day | rat | dermal | 21-day | irritation | p.69 |
| Regulatory source | repeated dose toxicity | 2.5 | % | rat | oral | Sub-chronic | repeated dose toxicity | p.66 |
| Regulatory source | repeated dose toxicity | 100 | mg/kg bw/day | rat | oral | 1 year | repeated dose toxicity | p.67 |
| Regulatory source | repeated dose toxicity | 200 | mg/kg bw/day | rat | oral | Sub-acute | repeated dose toxicity | p.65 |
| Regulatory source | repeated dose toxicity | 200 | mg/kg bw/day | rat | oral | 1-year | repeated dose toxicity | p.67 |
| Regulatory source | repeated dose toxicity | 1865 | mg/kg bw/day | mouse | dermal | 4-week | repeated dose toxicity | p.69 |
| Regulatory source | repeated dose toxicity | 4294 | mg/kg bw/day | mouse | oral | Sub-chronic | repeated dose toxicity | p.67 |
| Regulatory source | repeated dose toxicity | 10000 | mg/kg bw/day | rat | oral | Sub-acute | repeated dose toxicity | p.65 |
| Regulatory source | reproductive toxicity | 25 | mg/kg bw/d | mouse | oral | developmental | reproductive toxicity | p.50 |
| Regulatory source | reproductive toxicity | 25 | mg/kg bw/day | rabbit | - | developmental | reproductive toxicity | p.31 |
| Regulatory source | reproductive toxicity | 25 | mg/kg/d | rabbit | - | developmental | reproductive toxicity | p.31 |
| Regulatory source | reproductive toxicity | 25 | mg/kg/d | rabbit | oral | developmental | reproductive toxicity | p.31 |
| Regulatory source | reproductive toxicity | 25 | mg/kg bw/day | rat | - | developmental | reproductive toxicity | p.44 |
| Regulatory source | reproductive toxicity | 35 | mg/kg bw/d | rat | oral | 2-year | reproductive toxicity | p.32 |
| Regulatory source | reproductive toxicity | 35 | mg/kg bw/day | - | - | - | reproductive toxicity | p.70 |
| Regulatory source | reproductive toxicity | 35 | mg/kg bw/day | rat | oral | - | reproductive toxicity | p.70 |
| Regulatory source | reproductive toxicity | 39 | mg/kg bw/d | rat | oral | 2-year | reproductive toxicity | p.32 |
| Regulatory source | reproductive toxicity | 92 | mg/kg bw/day | rat | - | chronic | reproductive toxicity | p.71 |
| Regulatory source | reproductive toxicity | 92 | mg/kg bw/day | - | - | chronic | reproductive toxicity | p.71 |
| Regulatory source | reproductive toxicity | 92 | mg/kg bw/day | rat | oral | chronic | reproductive toxicity | p.71 |
| Regulatory source | reproductive toxicity | 100 | mg/kg | rabbit | - | chronic | reproductive toxicity | p.34 |
| Regulatory source | reproductive toxicity | 100 | mg/kg bw | rat | - | developmental | reproductive toxicity | p.37 |
| Regulatory source | reproductive toxicity | 100 | mg/kg bw/day | - | - | developmental | reproductive toxicity | p.75 |
| Regulatory source | reproductive toxicity | 100 | mg/kg bw/day | rabbit | oral | Prenatal | reproductive toxicity | p.75 |
| Regulatory source | reproductive toxicity | 100 | mg/kg bw/day | mouse | oral | Prenatal | reproductive toxicity | p.76 |
| Regulatory source | reproductive toxicity | 250 | mg/kg bw/day | rabbit | oral | Prenatal | reproductive toxicity | p.75 |
| Regulatory source | reproductive toxicity | 457 | mg/kg | rat | - | - | reproductive toxicity | p.33 |
| Regulatory source | reproductive toxicity | 457 | mg/kg bw/day | - | - | - | reproductive toxicity | p.70 |
| Regulatory source | reproductive toxicity | 457 | mg/kg bw/day | - | oral | - | reproductive toxicity | p.71 |
| Regulatory source | reproductive toxicity | 490 | mg/kg bw/day | rat | oral | - | reproductive toxicity | p.70 |
| Regulatory source | reproductive toxicity | 500 | mg/kg bw/d | - | - | chronic | reproductive toxicity | p.34 |
| Regulatory source | reproductive toxicity | 500 | mg/kg bw/day | - | - | - | reproductive toxicity | p.75 |
| Regulatory source | reproductive toxicity | 500 | mg/kg bw/day | rat | oral | chronic | reproductive toxicity | p.71 |
| Regulatory source | reproductive toxicity | 1450 | mg/kg bw/day | mouse | - | - | reproductive toxicity | p.73 |
| Regulatory source | reproductive toxicity | 2100 | mg/kg bw/day | mouse | oral | Developmental | reproductive toxicity | p.72 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | D343Z75HT8 | UNII | - | - | - | chemical | - |