O-PHENYLPHENOL
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for O-PHENYLPHENOL. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 39 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >=1000 mg/kg bw/day | dermal | rat | dermal | REACH |
| NOAEL | >=300 mg/kg bw/day | oral | dog | oral | REACH |
| NOAEL | 250 mg/kg bw/day | oral | mouse | oral | REACH |
| NOAEL | 1400 mg/kg bw/day | dermal | code:3543 | dermal | REACH |
| NOAEL | 300 other | oral | dog | oral | REACH |
| NOAEL | >200 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 100 mg/kg bw/day | oral | rabbit | oral | REACH |
| NOAEL | 100 mg/kg bw/day | oral | mouse | oral | REACH |
| NOAEL | 500 mg/kg bw/day | oral | rat | oral | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
osmetic products? In light of the data provided, the SCCS considers o-Phenylphenol safe when used as preservative up to a maximum concentration of 0.2 % in rinse-off and 0.15 % in leave- on cosmetic products. O-Phenylphenol and Sodium o-Phenylphenate, when used together: • should no
osmetic products? In light of the data provided, the SCCS considers o-Phenylphenol safe when used as preservative up to a maximum concentration of 0.2 % in rinse-off and 0.15 % in leave- on cosmetic products. O-Phenylphenol and Sodium o-Phenylphenate, when used together: • should no
osmetic products? In light of the data provided, the SCCS considers o-Phenylphenol safe when used as preservative up to a maximum concentration of 0.2 % in rinse-off and 0.15 % in leave- on cosmetic products. O-Phenylphenol and Sodium o-Phenylphenate, when used together: • should no
osmetic products? In light of the data provided, the SCCS considers o-Phenylphenol safe when used as preservative up to a maximum concentration of 0.2 % in rinse-off and 0.15 % in leave- on cosmetic products. O-Phenylphenol and Sodium o-Phenylphenate, when used together: • should no
osmetic products? In light of the data provided, the SCCS considers o-Phenylphenol safe when used as preservative up to a maximum concentration of 0.2 % in rinse-off and 0.15 % in leave- on cosmetic products. O-Phenylphenol and Sodium o-Phenylphenate, when used together: • should no
Expert Verdict
O-PHENYLPHENOL is listed in the EU CosIng database with functions: Preservative It is restricted under EU Cosmetics Regulation. Restriction: V/7 The use of o-phenylphenol as a preservative should be allowed with a maximum concentration of 0,15 % (as phenol) in leave-on and 0,2 % (as phenol) in rinse-off cosmetic products. Contact with eyes should be avoided. The use of sodium o-phenylphenate, potassium o-phenylphenate and MEA o-phenylphenate as preservatives should not be allowed..
Regulatory Flags
Frequently Asked Questions
Is O-PHENYLPHENOL safe in cosmetics?
O-PHENYLPHENOL is listed in the EU CosIng database with functions: Preservative It is restricted under EU Cosmetics Regulation. Restriction: V/7 The use of o-phenylphenol as a preservative should be allowed with a maximum concentration of 0,15 % (as phenol) in leave-on and 0,2 % (as phenol) in rinse-off cosmetic products. Contact with eyes should be avoided. The use of sodium o-phenylphenate, potassium o-phenylphenate and MEA o-phenylphenate as preservatives should not be allowed.. The EU classifies O-PHENYLPHENOL as "Restricted". Safety rating: MODERATE. 10 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by sccs.
Is O-PHENYLPHENOL allowed in the EU?
O-PHENYLPHENOL EU regulatory status: Restricted. Maximum allowed concentration: V/7 The use of o-phenylphenol as a preservative should be allowed with a maximum concentration of 0,15 % (as phenol) in leave-on and 0,2 % (as phenol) in rinse-off cosmetic products. Contact with eyes should be avoided. The use of sodium o-phenylphenate, potassium o-phenylphenate and MEA o-phenylphenate as preservatives should not be allowed.. This is based on EU Regulation 1223/2009 and its amendments.
What does O-PHENYLPHENOL do in cosmetics?
O-PHENYLPHENOL functions as: Preservative. It is classified as a cosmetic ingredient in our database. CAS number: 90-43-7.
What is the Margin of Safety for O-PHENYLPHENOL?
NOAEL: 25 mg/kg bw/day | Source: SCCS/1669/24 | Study: developmental tox rabbit The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for O-PHENYLPHENOL?
The NOAEL (No Observed Adverse Effect Level) for O-PHENYLPHENOL is 39 mg/kg bw/day based on a oral study via oral route in rat. A total of 10 study endpoints are available. Source: REACH.
Is O-PHENYLPHENOL classified as hazardous under GHS?
O-PHENYLPHENOL carries a GHS signal word of "WARNING". Hazard statements: May be harmful if swallowed Causes skin irritation Causes serious eye irritation May cause respiratory irritation Very toxic to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Compliance Tools
Check O-PHENYLPHENOL compliance across multiple jurisdictions:
Related Ingredients
Is O-PHENYLPHENOL in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for O-PHENYLPHENOL in your formulation.