NOAEL Studies Cosmetic Ingredient

P,ALPHA-DIMETHYLSTYRENE NOAEL Studies

CAS: 1195-32-0

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB NOAEL 0.6 mg/kg bw/day rat oral 90 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
EFSA 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA NOAEL =0.625 mg/kg bw/day Rat - 90 days subchronic EFSA AFC - 2009 - OutputID 2305 - Flavouring Group Evaluation 78 (FGE.78): Consideration of Aliphatic and alicyclic and aromatic hydrocarbons evaluated by JECFA (63rd meeting) structurally related to aliphatic and aromatic hydrocarbons evaluated by EFSA in FGE.25. Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food - doi:10.2903/j.efsa.2009.931
EFSA NOAEL =60 mg/kg bw/day Rat - - reproduction toxicity EFSA - 2014 - OutputID 2558 - development - teratogenic - Conclusion on the peer review of the pesticide risk assessment of the active substance terpenoid blend QRD-460 - doi:10.2903/j.efsa.2014.3816
EFSA NOAEL =200 mg/kg bw/day Rat oral: feed 90 days subchronic EFSA FEEDAP - 2019 - OutputID 3354 - no adverse effect observed at single/highest dose - Safety and efficacy of an essential oil from Origanum vulgare ssp. hirtum (Link) Ietsw. for all animal species - doi:10.2903/j.efsa.2019.5909
EFSA NOAEL =0.625 mg/kg bw/day Rat oral subchronic; 90 days subchronic LONG_REF=EFSA AFC (2009). Flavouring Group Evaluation 78 (FGE.78): Consideration of Aliphatic and alicyclic and aromatic hydrocarbons evaluated by JECFA (63rd meeting) structurally related to aliphatic and aromatic hydrocarbons evaluated by EFSA in FGE.25. Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food. doi:10.2903/j.efsa.2009.931.; TITLE=Flavouring Group Evaluation 78 (FGE.78): Consideration of Aliphatic and alicyclic and aromatic hydrocarbons evaluated by JECFA (63rd meeting) structurally related to aliphatic and aromatic hydrocarbons evaluated by EFSA in FGE.25. Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food; AUTHOR=EFSA AFC; DOI=doi:10.2903/j.efsa.2009.931; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=EFSA_dup_-_15621540_15621541_15621542:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_02155b32fbef3537cfedfcae43cb3604
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier XC8HY3OB86 UNII - - - chemical -