NOAEL Studies
Cosmetic Ingredient
P-AMINOPHENOL NOAEL Studies
CAS: 123-30-8
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS DB 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS DB | LOAEL | 30 | mg/kg bw/day | rat | oral | 90 day | Subchronic | REACH; study report |
| COSMOS DB | LOAEL | 133 | mg/kg bw/day | rat | oral | 6 month | Subchronic | REACH; Food Chem. Toxicol. Vol. 27, No. 10, pp. 691-698. |
| COSMOS DB | NOAEL | 10 | mg/kg bw/day | rat | oral | 90 day | Subchronic | REACH; study report |
| COSMOS DB | NOAEL | 47 | mg/kg bw/day | rat | oral | 6 month | Subchronic | REACH; Food Chem. Toxicol. Vol. 27, No. 10, pp. 691-698. |
EFSA 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA | NOAEL | =3.2 | mg/kg bw/day | Rat | - | 730 days | chronic/long term toxicity | EFSA - 2018 - OutputID 3028 - haematology - hemopoietic - Peer review of the pesticide risk assessment of the active substance desmedipham - doi:10.2903/j.efsa.2018.5150 |
| EFSA | NOAEL | =5.2 | mg/kg bw/day | Rat | oral: unspecified | 90 days | subchronic | EFSA - 2018 - OutputID 3028 - haematology - hemopoietic - Peer review of the pesticide risk assessment of the active substance desmedipham - doi:10.2903/j.efsa.2018.5150 |
| EFSA | ADI | =0.016 | mg/kg bw/day | Consumers | - | - | ADI | EFSA - 2018 - OutputID 3028 - Consumers - Peer review of the pesticide risk assessment of the active substance desmedipham - doi:10.2903/j.efsa.2018.5150 |
| EFSA | ARfD | =0.05 | mg/kg bw/day | Consumers | - | - | ARfD | EFSA - 2018 - OutputID 3028 - Consumers - Peer review of the pesticide risk assessment of the active substance desmedipham - doi:10.2903/j.efsa.2018.5150 |
| EFSA | NOAEL | =3.2 | mg/kg bw/day | Rat | oral | chronic; 2 years | chronic | LONG_REF=EFSA (2018). Peer review of the pesticide risk assessment of the active substance desmedipham. doi:10.2903/j.efsa.2018.5150.; TITLE=Peer review of the pesticide risk assessment of the active substance desmedipham; AUTHOR=EFSA; DOI=doi:10.2903/j.efsa.2018.5150; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2018; ORIGINAL_YEAR=2018; TOXICOLOGICAL_EFFECT=hematological; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=EFSA:15625317:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d287fb5fcc1cd4c8ad5ca5fdd2f22372 |
| EFSA | NOAEL | =5.2 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=EFSA (2018). Peer review of the pesticide risk assessment of the active substance desmedipham. doi:10.2903/j.efsa.2018.5150.; TITLE=Peer review of the pesticide risk assessment of the active substance desmedipham; AUTHOR=EFSA; DOI=doi:10.2903/j.efsa.2018.5150; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2018; ORIGINAL_YEAR=2018; TOXICOLOGICAL_EFFECT=hematological; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=EFSA:15625318:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_523fe79c0a3611e2be0482cac15064bb |
NTP ICE acute inhalation 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute inhalation | LC50 | >0.005 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2035; Record_ID=acute_inhalation_3058; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID3024499; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=0.005; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3024499; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3024499 |
SCCS Opinion 9 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCS Opinion | NOAEL | =0.067 | mg/kg bw/d | rat | oral | 90-day | dermal absorption | p.48 |
| SCCS Opinion | NOAEL | =3 | - | rat | oral | - | NOAEL study | (Ref. KM9), p.47 |
| SCCS Opinion | NOAEL | =6.9 | µg/cm | human | dermal | - | dermal absorption | p.48 |
| SCCS Opinion | NOAEL | =10 | mg/kg | rat | oral | subchronic | repeated dose toxicity | p.39 |
| SCCS Opinion | NOAEL | =10 | mg/kg bw/day | rabbit | dermal | 13 weeks | NOAEL study | Ref.: Col, p.17 |
| SCCS Opinion | NOAEL | =10 | mg/kg bw/d | rat | oral | 90-day | dermal absorption | p.48 |
| SCCS Opinion | NOAEL | =24 | - | human | - | - | NOAEL study | Ref.: Col, p.31 |
| SCCS Opinion | NOAEL | =25 | mg/kg | rat | oral | 90 day | genotoxicity | p.39 |
| SCCS Opinion | NOAEL | =1409 | - | human | - | - | NOAEL study | Ref.: KM4), p.47 |
ECHA 9 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LEL | =467 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead1be4b0a7c65d1c2849; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6216/7/6/2?documentUUID=f29f0e2c-59c9-4496-b308-258a6ac468f8; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID:15835473:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9f86127d67abff16a24b676e8deab829 |
| ECHA | LEL | =667 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa7ee4b0a7c65d1b61ae; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6216/7/9/2?documentUUID=f29f0e2c-59c9-4496-b308-258a6ac468f8; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855362_15856190:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c08ba1e5129f7802ca638c5910fe56bd |
| ECHA | LOAEL | =133 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead1be4b0a7c65d1c2849; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6216/7/6/2?documentUUID=f29f0e2c-59c9-4496-b308-258a6ac468f8; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID:15835472:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1ef388f455862e3402b8d9eff45f1a57 |
| ECHA | LOEL | =30 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead1be4b0a7c65d1c2845; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6216/7/6/2?documentUUID=f29f0e2c-59c9-4496-b308-258a6ac468f8; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15832158_15832159:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_379fca27e5ee6549287d10cb9e6b9b1f |
| ECHA | NOAEL | =10 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead1be4b0a7c65d1c2845; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6216/7/6/2?documentUUID=f29f0e2c-59c9-4496-b308-258a6ac468f8; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15832158_15832159:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_02d63c891a48a90f950476c08c3d1e33 |
| ECHA | NOAEL | =20 | mg/kg bw/day | Rat | oral | short-term; 28 days | short-term | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead1be4b0a7c65d1c284b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6216/7/6/2?documentUUID=f29f0e2c-59c9-4496-b308-258a6ac468f8; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID:15846162:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f799ef65e12a4fe523120f582af318c0 |
| ECHA | NOAEL | =100 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabd2e4b0a7c65d1bbeac; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6216/7/9/3?documentUUID=f29f0e2c-59c9-4496-b308-258a6ac468f8; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=fetus: fetal/pup body weight changes; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15820636:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_eafda469e3437ee27b5e6fc4f02f9b30 |
| ECHA | NOAEL | =333 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa7ee4b0a7c65d1b61ae; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6216/7/9/2?documentUUID=f29f0e2c-59c9-4496-b308-258a6ac468f8; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=P0: body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855362_15856190:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5a29408b5f0d11995f57a2a74f2e234d |
| ECHA | NOEC | =30 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9d8e4b0a7c65d1b30a9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6216/7/8?documentUUID=f29f0e2c-59c9-4496-b308-258a6ac468f8; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID:15817677:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f9ca255f06e9259a9fe8645963061f63 |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =2.1 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15629767:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f5e9a5e748d1ebfd1add381b4b1c068f |
ToxValDB PPRTV (CPHEA) 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB PPRTV (CPHEA) | NOAEL | =50 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=Burnett el al 1989; AUTHOR=Burnett el al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754fce4b08a6b3934bd0a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1567; TOXICOLOGICAL_EFFECT=tubular necrosis, increased levels of enzymes indicative of renal failure, measures of impaired renal function; TOXICOLOGICAL_EFFECT_CATEGORY=multiple; STUDY_GROUP=PPRTV (CPHEA):15654005:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0fddf03c9b259d923e1b041337c4b2e6 |
| ToxValDB PPRTV (CPHEA) | RfD (provisional) | =0.02 | mg/kg bw/day | Human | oral | - | Toxicity Value | LONG_REF=Burnett el al 1989; AUTHOR=Burnett el al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754fce4b08a6b3934bd0a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1567; TOXICOLOGICAL_EFFECT=Tubular necrosis, increased levels of enzymes indicative of renal failure, measures of impaired renal function in male/female rats; STUDY_GROUP=PPRTV (CPHEA)_dup_PPRTV Summary_15653504_15653664:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a224ff6c7be5515616e16f191d9635a7 |
| ToxValDB PPRTV (CPHEA) | RfD (provisional) | =0.2 | mg/kg bw/day | Human | oral | - | Toxicity Value | LONG_REF=Burnett el al 1989; AUTHOR=Burnett el al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754fce4b08a6b3934bd0a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1567; TOXICOLOGICAL_EFFECT=Tubular necrosis, increased levels of enzymes indicative of renal failure, measures of impaired renal function in male/female rats; STUDY_GROUP=PPRTV (CPHEA)_dup_PPRTV Summary_15653504_15653664:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c595d9b945ad997b27dbd5611bc524f3 |
Regulatory source 10 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | - | 3 | - | rat | oral | - | - | p.47 |
| Regulatory source | - | 10 | mg/kg bw/day | rabbit | dermal | 13 weeks | - | p.17 |
| Regulatory source | - | 24 | - | human | - | - | - | p.31 |
| Regulatory source | - | 1409 | - | human | - | - | - | p.47 |
| Regulatory source | dermal absorption | =0.067 | mg/kg bw/d | rat | oral | 90-day | dermal absorption | p.48 |
| Regulatory source | dermal absorption | =6.9 | µg/cm | human | dermal | - | dermal absorption | p.48 |
| Regulatory source | dermal absorption | =10 | mg/kg bw/d | rat | oral | 90-day | dermal absorption | p.48 |
| Regulatory source | genotoxicity | 25 | mg/kg | rat | oral | 90 day | genotoxicity | p.39 |
| Regulatory source | repeated dose toxicity | 10 | mg/kg | rat | oral | subchronic | repeated dose toxicity | p.39 |
| Regulatory source | repeated dose toxicity | 10 | mg/kg bw/day | rabbit | dermal | subchronic | repeated dose toxicity | p.50 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | R7P8FRP05V | UNII | - | - | - | chemical | - |