NOAEL Studies Cosmetic Ingredient

P-HYDROXYANISOLE NOAEL Studies

CAS: 150-76-5

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =1600 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_2895; row=6964; data_type=In Vivo; mixture=Chemical; chemical_name=4-Methoxyphenol; preferred_name=4-Methoxyphenol; dtxsid=DTXSID4020828; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020828; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID4020828; source_file=acute_oral.xlsx
NTP_ICE_adme_parameters 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_adme_parameters Clint 36 uL/min/10^6 cells Human - - Measured; httk, Human Hepatic Intrinsic Clearance sheet=Data; excel_row=1576; Record_ID=adme_parameters_899; Data_Type=Measured; DTXSID=DTXSID4020828; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=36.0; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020828; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4020828
NTP_ICE_endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=3970; RecordID=ARPathway2016_882; DatasetName=ARPathway2016; DTXSID=DTXSID4020828; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020828; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4020828
ToxValDB_ECHA_IUCLID 10 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LOAEL =225 mg/kg bw/day Hamster oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c819e4b0a7c65d2169f7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16005/7/8?documentUUID=9db42296-4240-43ed-bb91-bb8d1ba165a5; STUDY_GROUP=ECHA IUCLID:15816415:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_343cb9ee1924d86c69bdf2d4664e36fd
ToxValDB_ECHA_IUCLID LOAEL =375 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c819e4b0a7c65d2169fd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16005/7/8?documentUUID=9db42296-4240-43ed-bb91-bb8d1ba165a5; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15817302_15820355:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d1e6f94a0287524880004ba86994f176
ToxValDB_ECHA_IUCLID LOAEL =500 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9f0e4b0a7c65d1b37bb; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16005/7/8?documentUUID=9db42296-4240-43ed-bb91-bb8d1ba165a5; YEAR=0; ORIGINAL_YEAR=0; STUDY_GROUP=ECHA IUCLID:15820354:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_53ad15a6c9ef90e544f3d854009a1da5
ToxValDB_ECHA_IUCLID LOAEL =100 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9f0e4b0a7c65d1b37be; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16005/7/8?documentUUID=9db42296-4240-43ed-bb91-bb8d1ba165a5; YEAR=0; ORIGINAL_YEAR=0; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15817302_15820355:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3fc8968699872f8149f1e949efe834cf
ToxValDB_ECHA_IUCLID LOAEL =300 mg/kg bw/day Rat oral subchronic (developmental); 39 days reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca91e4b0a7c65d2228c6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16005/7/6/2?documentUUID=9db42296-4240-43ed-bb91-bb8d1ba165a5; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15834836_15847899:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_79e94ad7c69c45c62644cc840deb4e85
ToxValDB_ECHA_IUCLID NOAEL =200 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabe9e4b0a7c65d1bc6ca; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16005/7/9/3?documentUUID=9db42296-4240-43ed-bb91-bb8d1ba165a5; TOXICOLOGICAL_EFFECT=fetus: reduction in number of live offspring|fetus: fetal/pup body weight changes|fetus: external malformations|fetus: skeletal malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820924_15823398:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9fbfa0d1a23dd3488bd73f7a230f20ff
ToxValDB_ECHA_IUCLID NOAEL =40 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabe9e4b0a7c65d1bc6cc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16005/7/9/3?documentUUID=9db42296-4240-43ed-bb91-bb8d1ba165a5; TOXICOLOGICAL_EFFECT=maternal: clinical signs|maternal: food consumption and compound intake|maternal: histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|food and/or water consumption|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15822849_15823315:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0b07757dd63b668cc37e8ad3c226fd36
ToxValDB_ECHA_IUCLID NOAEL =100 mg/kg bw/day Rabbit oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabe9e4b0a7c65d1bc6ce; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16005/7/9/3?documentUUID=9db42296-4240-43ed-bb91-bb8d1ba165a5; YEAR=0; ORIGINAL_YEAR=0; TOXICOLOGICAL_EFFECT=maternal: body weight and weight gain|maternal: food consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ECHA IUCLID:15823254:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b8e07f68e1ba9b605133451afdfb0e2e
ToxValDB_ECHA_IUCLID NOAEL =250 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabe9e4b0a7c65d1bc6cc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16005/7/9/3?documentUUID=9db42296-4240-43ed-bb91-bb8d1ba165a5; YEAR=0; ORIGINAL_YEAR=0; TOXICOLOGICAL_EFFECT=fetus: reduction in number of live offspring|fetus: changes in litter size and weights; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820924_15823398:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6d13bfad5d90816a334b8a96d86be1e7
ToxValDB_ECHA_IUCLID NOAEL =150 mg/kg bw/day Rat oral subchronic (developmental); 39 days reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca91e4b0a7c65d2228c6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16005/7/6/2?documentUUID=9db42296-4240-43ed-bb91-bb8d1ba165a5; YEAR=0; ORIGINAL_YEAR=0; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15834836_15847899:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ab6976306517564ba3bbfcd3e8c9c556
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =3 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15633227:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_68bfb29180901c0cdf2b2eb182d43e10
ToxValDB_HPVIS 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_HPVIS NOAEL =40 mg/kg bw/day Rat dermal - developmental LONG_REF=FDA Center for Drug Evaluation and Research Application Number 20-922. Pharmacology review(s). Evaluation of Pharmacology and Toxicology Data, Division of Dermatologic and Dental Drug Products, HFD-540. Submitted 12/30/97. http://www.fda.gov/cder/foi/nda/99/20-922 Solage biopharmr.pdf; TITLE=Application Number 20-922. Pharmacology review(s). Evaluation of Pharmacology and Toxicology Data, Division of Dermatologic and Dental Drug Products, HFD-540; AUTHOR=FDA Center for Drug Evaluation and Research; QUALITY=2; EXTERNAL_SOURCE_ID=65342; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480598; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=HPVIS:15643182:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_af2653209f81acec075e43a3521dbbe7
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 6HT8U7K3AM UNII - - - chemical {"approval_status":null,"molecular_formula":"C7H8O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"6HT8U7K3AM"}
openFDA substances FDA UNII substance identifier 6HT8U7K3AM UNII - - - chemical {"approval_status":null,"molecular_formula":"C7H8O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"6HT8U7K3AM"}
openFDA substances FDA UNII substance identifier 6HT8U7K3AM UNII - - - chemical {"approval_status":null,"molecular_formula":"C7H8O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"6HT8U7K3AM"}
openFDA substances FDA UNII substance identifier 6HT8U7K3AM UNII - - - chemical {"approval_status":null,"molecular_formula":"C7H8O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"6HT8U7K3AM"}