Moderate Cosmetic Ingredient NOAEL Data GHS Classified

P-HYDROXYANISOLE

CAS Number
150-76-5
Function
Antioxidant, Reducing
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status Restricted
EU Max Conc. III/95
🇺🇸 US Status Not specifically regulated

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Toxicological Studies

4 study endpoints found for P-HYDROXYANISOLE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 150 mg/kg bw/day oral rat oral REACH
LOAEL ca.1650 other oral rat oral REACH
NOAEL 92.5 other oral rat oral REACH
LOAEL ca.1850 other oral rat oral REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance is irritating to the eyes and skin.
Long-term Exposure Effects
Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the skin. This may result in depigmentation.
Routes of Exposure
The substance can be absorbed into the body by ingestion.

Expert Verdict

P-HYDROXYANISOLE is listed in the EU CosIng database with functions: Antioxidant, Reducing It is restricted under EU Cosmetics Regulation. Restriction: III/95.

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Concern Level: Medium

Regulatory Flags

cosing-sourced eu-restricted antioxidant needs-enrichment eu_cosing_listed

Frequently Asked Questions

Is P-HYDROXYANISOLE safe in cosmetics?

P-HYDROXYANISOLE is listed in the EU CosIng database with functions: Antioxidant, Reducing It is restricted under EU Cosmetics Regulation. Restriction: III/95. The EU classifies P-HYDROXYANISOLE as "Restricted". Safety rating: MODERATE. 4 toxicological study endpoint(s) are available in our database.

Is P-HYDROXYANISOLE allowed in the EU?

P-HYDROXYANISOLE EU regulatory status: Restricted. Maximum allowed concentration: III/95. This is based on EU Regulation 1223/2009 and its amendments.

What does P-HYDROXYANISOLE do in cosmetics?

P-HYDROXYANISOLE functions as: Antioxidant, Reducing. It is classified as a cosmetic ingredient in our database. CAS number: 150-76-5.

What is the NOAEL for P-HYDROXYANISOLE?

The NOAEL (No Observed Adverse Effect Level) for P-HYDROXYANISOLE is 150 mg/kg bw/day based on a oral study via oral route in rat. A total of 4 study endpoints are available. Source: REACH.

Compliance Tools

Check P-HYDROXYANISOLE compliance across multiple jurisdictions:

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Ingredient Decoder
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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