PEG-200
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for PEG-200. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1690 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 2000 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 1820 mg/kg bw/day | oral | dog | Chronic | COSMOS_DB |
| NOAEL | 1600 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 4050 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 230 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 7500 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 10900 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 1128 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 25000 mg/kg bw/day | oral | mouse | Short Term Toxicity | COSMOS_DB |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
1,4-Dioxane and ethylene oxide residuals present; should not be applied to damaged or compromised skin.
Regulatory Flags
Frequently Asked Questions
Is PEG-200 safe in cosmetics?
1,4-Dioxane and ethylene oxide residuals present; should not be applied to damaged or compromised skin. The EU classifies PEG-200 as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is PEG-200 allowed in the EU?
PEG-200 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does PEG-200 do in cosmetics?
PEG-200 functions as: Humectant; Solvent; Skin conditioning agent. It is classified as a cosmetic ingredient in our database. CAS number: 25322-68-3.
What is the Margin of Safety for PEG-200?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for PEG-200?
The NOAEL (No Observed Adverse Effect Level) for PEG-200 is 1690 mg/kg bw/day based on a Chronic study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
Check PEG-200 compliance across multiple jurisdictions:
Related Ingredients
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