Good Cosmetic Ingredient NOAEL Data

PEG-4 SORBITAN STEARATE

CAS Number

9005-67-8

Function

Surfactant - Emulsifying

Safety Rating

GOOD

Regulatory Status

🇪🇺 EU Status Permitted

🇺🇸 US Status restricted

US Notes CIR: SQ - Final Report 6/2015 Available from CIR

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Toxicological Studies

8 study endpoints found for PEG-4 SORBITAN STEARATE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint	Value	Route	Species	Study Type	Source
NOAEL	5000 mg/kg bw/day	oral	rat	Chronic	COSMOS_DB
NOAEL	15000 mg/kg bw/day	oral	mouse	Subchronic	COSMOS_DB
NOAEL	7500 mg/kg bw/day	oral	hamster	Chronic	COSMOS_DB
NOAEL	2500 mg/kg bw/day	oral	rat	Chronic	COSMOS_DB
NOAEL	15000 mg/kg bw/day	oral	mouse	Multigeneration Reproductive	COSMOS_DB
NOAEL	5000 mg/kg bw/day	oral	rat	Multigeneration Reproductive	COSMOS_DB
NOAEL	7693 mg/kg bw/day	oral	rat	Developmental	COSMOS_DB
dose_tested	7693 mg/kg bw/day	oral	rat	Developmental	COSMOS_DB

Expert Verdict

PEG-4 SORBITAN STEARATE is listed in the EU CosIng database with functions: Surfactant - Emulsifying It is permitted in the EU without specific restrictions.

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Concern Level: Low

Regulatory Flags

cosing-sourced eu-permitted surfactant needs-enrichment eu_children_restricted epa_safer_alternative ifra_fragrance fda_food_additive

Frequently Asked Questions

Is PEG-4 SORBITAN STEARATE safe in cosmetics?

PEG-4 SORBITAN STEARATE is listed in the EU CosIng database with functions: Surfactant - Emulsifying It is permitted in the EU without specific restrictions. The EU classifies PEG-4 SORBITAN STEARATE as "Permitted". Safety rating: GOOD. 8 toxicological study endpoint(s) are available in our database.

Is PEG-4 SORBITAN STEARATE allowed in the EU?

PEG-4 SORBITAN STEARATE EU regulatory status: Permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does PEG-4 SORBITAN STEARATE do in cosmetics?

PEG-4 SORBITAN STEARATE functions as: Surfactant - Emulsifying. It is classified as a cosmetic ingredient in our database. CAS number: 9005-67-8.

What is the NOAEL for PEG-4 SORBITAN STEARATE?

The NOAEL (No Observed Adverse Effect Level) for PEG-4 SORBITAN STEARATE is 5000 mg/kg bw/day based on a Chronic study via oral route in rat. A total of 8 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

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