Good Cosmetic Ingredient NOAEL Data GHS Classified

PEG-8

CAS Number

25322-68-3

Function

Humectant, solvent, skin conditioning agent, viscosity decreasing agent

Safety Rating

GOOD

Regulatory Status

🇪🇺 EU Status permitted

🇺🇸 US Status permitted

US Notes CIR: Safe in present practices of use and concentration; highest reported use 85% in non-coloring hair products

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)

adequate

Dermal Absorption

moderate

Sensitization

low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for PEG-8. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint	Value	Route	Species	Study Type	Source
NOAEL	1690 mg/kg bw/day	oral	rat	Chronic	COSMOS_DB
NOAEL	2000 mg/kg bw/day	oral	rat	Chronic	COSMOS_DB
NOAEL	1820 mg/kg bw/day	oral	dog	Chronic	COSMOS_DB
NOAEL	1600 mg/kg bw/day	oral	rat	Subchronic	COSMOS_DB
NOAEL	4050 mg/kg bw/day	oral	rat	Subchronic	COSMOS_DB
NOAEL	230 mg/kg bw/day	oral	rat	Subchronic	COSMOS_DB
NOAEL	7500 mg/kg bw/day	oral	rat	Subchronic	COSMOS_DB
NOAEL	10900 mg/kg bw/day	oral	rat	Subchronic	COSMOS_DB
NOAEL	1128 mg/kg bw/day	oral	rat	Subchronic	COSMOS_DB
NOAEL	25000 mg/kg bw/day	oral	mouse	Short Term Toxicity	COSMOS_DB

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Expert Verdict

⚠️

Concern Level: Low

Regulatory Flags

peg-ingredient eu_children_restricted epa_safer_alternative ifra_fragrance fda_food_additive

Frequently Asked Questions

Is PEG-8 safe in cosmetics?

Highest dermal penetration risk in this set due to low molecular weight; potential 1,4-dioxane and ethylene oxide residues; peroxide accumulation on aging; avoid application to burns or transepidermal wounds The EU classifies PEG-8 as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.

Is PEG-8 allowed in the EU?

PEG-8 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does PEG-8 do in cosmetics?

PEG-8 functions as: Humectant, solvent, skin conditioning agent, viscosity decreasing agent. It is classified as a cosmetic ingredient in our database. CAS number: 25322-68-3.

What is the Margin of Safety for PEG-8?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for PEG-8?

The NOAEL (No Observed Adverse Effect Level) for PEG-8 is 1690 mg/kg bw/day based on a Chronic study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check PEG-8 compliance across multiple jurisdictions:

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Ingredient Decoder

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82 Allergen Checker

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Substance Compliance

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MoS Calculator

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Heavy Metal Limits

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